A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study

Dongmei Gu   ^{1, 2} , MM ;   Xiaozhen Lv   ^{1, 2} , PhD ;   Chuan Shi   ^{1, 2} , MD, PhD ;   Tianhong Zhang   ³ , MD, PhD ;   Sha Liu   ⁴ , PhD ;   Zili Fan   ^{1, 2, 5} , PhD ;   Lihui Tu   ^{1, 2, 5} , PhD ;   Ming Zhang   ^{1, 2, 6} , PhD ;   Nan Zhang   ⁷ , MD, PhD ;   Liming Chen   ⁸ , PhD ;   Zhijiang Wang   ^{1, 2} , PhD ;   Jing Wang   ^{1, 2} , PhD ;   Ying Zhang   ^{1, 2, 5} , PhD ;   Huizi Li   ^{1, 2} , MM ;   Luchun Wang   ^{1, 2} , MM ;   Jiahui Zhu   ^{1, 2} , MM ;   Yaonan Zheng   ^{1, 2} , MSc ;   Huali Wang   ^{1, 2 *} , MD ;   Xin Yu   ^{1, 2 *} , MD ;   Alzheimer's Disease Neuroimaging Initiative (ADNI)   ⁹

¹ Clinical Research Division, Dementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China

² Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders (Peking University), National Health Committee Key Laboratory of Mental Health, Beijing, China

³ Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

⁴ Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China

⁵ Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China

⁶ Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

⁷ Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China

⁸ China Telecom Digital Intelligence Technology Co.,Ltd, Beijing, China

⁹ see Acknowledgements

*these authors contributed equally