Precision Medicine

Scalable Precision Psychiatry With an Objective Measure of Psychological Stress: Prospective Real-World Study

Helena Wang, Norman Farb, Bechara Saab

J Med Internet Res 2025 (Jul 07); 27:e56086

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Optimizing Vital Signs in Patients With Traumatic Brain Injury: Reinforcement Learning Algorithm Development and Validation

Hongwei Zhang, Mengyuan Diao, Sheng Zhang, Peifeng Ni, Weidong Zhang, Chenxi Wu, Ying Zhu, Wei Hu

J Med Internet Res 2025 (Jul 03); 27:e63847

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In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

JMIR Res Protoc 2025 (Jun 30); 14:e73383

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Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

Pradeep S Virdee, Kiana K Collins, Claire Friedemann Smith, Xin Yang, Sufen Zhu, Nia Roberts, Jason L Oke, Clare Bankhead, Rafael Perera, FD Richard Hobbs, Brian D Nicholson

JMIR Cancer 2025 (Jun 27); 11:e70275

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Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers of Children With Neurogenetic Conditions (Project WellCAST): Protocol for a Randomized Controlled Trial

Bridgette Kelleher, Kaleb Emerson, Lyndsey N Graham, Veronika Vozka, Anne Wheeler, William Fadel, Daniel Foti, Isha Metzger, Mandy Rispoli, Wendy Machalicek, Laurie McLay, Sean Lane, Wei Siong Neo, Allie Carter, Lisa Brown, Jennifer Brown, Laura Lee McIntyre, Elizabeth Salwitz, Gloria Dietz, Riley Naughton, Katlyn Peek, Nicole Hollins, Emma Woodford

JMIR Res Protoc 2025 (Jun 25); 14:e64360

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Virtual Diabetes Prevention Program Tailored to Increase Participation of Black and Latino Men: Protocol for a Randomized Controlled Trial

Earle C Chambers, Elizabeth A Walker, Clyde Schechter, Eric Gil, Terysia Herbert, Katelyn Diaz, Jeffrey Gonzalez

JMIR Res Protoc 2025 (Jun 24); 14:e64405

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Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study

Sriram Ramgopal, Paul Aronson, Douglas Lorenz, Alexander Joseph Rogers, Andrea Tania Cruz

JMIR Res Protoc 2025 (Jun 19); 14:e66722

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Effects of Selective Head-and-Neck Cooling on Brain Injury-Related Biomarker Levels and Symptom Rating Following a Boxing Bout: Protocol for an Exploratory Randomized Trial

Ali Al-Husseini, Yelverton Tegner, Kaj Blennow, Henrik Zetterberg, Niklas Marklund

JMIR Res Protoc 2025 (Jun 16); 14:e68954

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A Knowledge-Enhanced Platform (MetaSepsisKnowHub) for Retrieval Augmented Generation–Based Sepsis Heterogeneity and Personalized Management: Development Study

Chi Zhang, Hao Yang, Xingyun Liu, Rongrong Wu, Hui Zong, Erman Wu, Yi Zhou, Jiakun Li, Bairong Shen

J Med Internet Res 2025 (Jun 06); 27:e67201

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Big Data–Driven Health Portraits for Personalized Management in Noncommunicable Diseases: Scoping Review

Haoyang Du, Jianing Yu, Dandan Chen, Jingjie Wu, Erxu Xue, Yufeng Zhou, Xiaohua Pan, Jing Shao, Zhihong Ye

J Med Internet Res 2025 (Jun 05); 27:e72636

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Data Inaccessibility Is Stifling the Digital Twin Implementation in Health Care

Md Doulotuzzaman Xames

J Med Internet Res 2025 (Jun 03); 27:e76524

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Understanding Gender-Specific Daily Care Preferences: Topic Modeling Study

Kyungmi Woo, Se Hee Min, Aeri Kim, Subin Choi, Gregory L Alexander, Terrence O’Malley, Maria D Moen, Maxim Topaz

J Med Internet Res 2025 (May 29); 27:e64160

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ENABLE—App-Based Digital Capture and Intervention of Patient-Reported Quality of Life, Adverse Events, and Treatment Satisfaction in Breast Cancer: Protocol for a Randomized Controlled Trial

Thomas M Deutsch, Léa L Volmer, Manuel Feisst, Laura Bodenbeck, Kathrin Hassdenteufel, Lara Tretschock, Christiane Breit, Stefan Stefanovic, Armin Bauer, Carolin Anders, Lina Weinert, Tobias Engler, Andreas D Hartkopf, Nico Pfeifer, Pascal Escher, Marc Mausch, Oliver Heinze, Marc Suetterlin, Sara Y Brucker, Andreas Schneeweiss, Markus Wallwiener

JMIR Res Protoc 2025 (May 26); 14:e69855

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Immunogenicity of COVID-19 Vaccination in Immunocompromised Patients (Auto-COVID-VACC): Protocol for Multicenter Prospective Noninterventional Study

Louise Marie Cremer, Ullrich Bethe, Peter Borchmann, Veronica Di Cristanziano, Lutz Gieselmann, Sarah Grimm, Martin Hellmich, Julia Jakobs, Julia A Nacov, Julia M Neuhann, Juergen Prattes, Christoph Scheid, Rosanne Sprute, Gertrud Steger, Jannik Stemler, Sibylle C Mellinghoff, Oliver A Cornely

JMIR Res Protoc 2025 (May 26); 14:e60675

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Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study

Ken Nagino, Yasutsugu Akasaki, Nobuo Fuse, Soichi Ogishima, Atsushi Shimizu, Akira Uruno, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Fuji Nagami, Jun Seita, Tomohiro Nakamura, Satoshi Nagaie, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Atsuko Eguchi, Akie Midorikawa-Inomata, Masahiro Nakamura, Akira Murakami, Shintaro Nakao, Takenori Inomata

JMIR Res Protoc 2025 (May 12); 14:e67862

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Forecasting Subjective Cognitive Decline: AI Approach Using Dynamic Bayesian Networks

Antti Etholén, Teemu Roos, Mirja Hänninen, Ioanna Bouri, Jenni Kulmala, Ossi Rahkonen, Anne Kouvonen, Tea Lallukka

J Med Internet Res 2025 (May 06); 27:e65028

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Trust and Privacy Concerns Among Cancer Survivors Who Did Not Visit a Research Website Offering Free Genetic Counseling Services for Families: Survey Study

James A Shepperd, Colleen M McBride, Weihua An, Jingsong Zhao, Rebecca D Pentz, Cam Escoffery, Kevin Ward, Yue Guan

J Med Internet Res 2025 (May 06); 27:e64228

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The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study

An Tuan Huynh, Hoang Anh Vu, Ho Quoc Chuong, Tien Hoang Anh, An Viet Tran

JMIR Cardio 2025 (May 01); 9:e71016

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Survival Tree Analysis of Interactions Among Factors Associated With Colorectal Cancer Risk in Patients With Type 2 Diabetes: Retrospective Cohort Study

Sarah Tsz Yui Yau, Chi Tim Hung, Eman Yee Man Leung, Albert Lee, Eng Kiong Yeoh

JMIR Public Health Surveill 2025 (Apr 29); 11:e62756

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Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Andrew Hooyman, Matt J Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y Schaefer

JMIR Aging 2025 (Apr 24); 8:e67298

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