Precision Medicine

AI-Derived Blood Biomarkers for Ovarian Cancer Diagnosis: Systematic Review and Meta-Analysis

He-Li Xu, Xiao-Ying Li, Ming-Qian Jia, Qi-Peng Ma, Ying-Hua Zhang, Fang-Hua Liu, Ying Qin, Yu-Han Chen, Yu Li, Xi-Yang Chen, Yi-Lin Xu, Dong-Run Li, Dong-Dong Wang, Dong-Hui Huang, Qian Xiao, Yu-Hong Zhao, Song Gao, Xue Qin, Tao Tao, Ting-Ting Gong, Qi-Jun Wu

J Med Internet Res 2025 (Mar 24); 27:e67922

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A Hybrid Deep Learning–Based Feature Selection Approach for Supporting Early Detection of Long-Term Behavioral Outcomes in Survivors of Cancer: Cross-Sectional Study

Tracy Huang, Chun-Kit Ngan, Yin Ting Cheung, Madelyn Marcotte, Benjamin Cabrera

JMIR Bioinform Biotech 2025 (Mar 13); 6:e65001

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Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025 (Mar 10); 14:e44027

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FRAILSURVEY—an mHealth App for Self-Assessment of Frailty Based on the Portuguese Version of the Groningen Frailty Indicator: Validation and Reliability Study

Luis Midao, Mafalda Duarte, Rute Sampaio, Marta Almada, Cláudia Camila Dias, Constança Paúl, Elísio Costa

JMIR Form Res 2025 (Mar 07); 9:e51975

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Retrieval Augmented Therapy Suggestion for Molecular Tumor Boards: Algorithmic Development and Validation Study

Eliza Berman, Holly Sundberg Malek, Michael Bitzer, Nisar Malek, Carsten Eickhoff

J Med Internet Res 2025 (Mar 05); 27:e64364

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Advancing Health Care With Digital Twins: Meta-Review of Applications and Implementation Challenges

Mickaël Ringeval, Faustin Armel Etindele Sosso, Martin Cousineau, Guy Paré

J Med Internet Res 2025 (Feb 19); 27:e69544

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Histopathological Comparison and Expression Analysis of COL1A1, COL3A1, and ELN in the Proximal and Distal Ventral Dartos of Patients With Hypospadias: Protocol for Prospective Case-Control Study

Putu Angga Risky Raharja, Ponco Birowo, Lisnawati Rachmadi, Heri Wibowo, Aria Kekalih, Gede Wirya Kusuma Duarsa, Tariq Abbas, Irfan Wahyudi

JMIR Res Protoc 2025 (Feb 18); 14:e70075

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Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study

Suresh K Bhavnani, Weibin Zhang, Daniel Bao, Mukaila Raji, Veronica Ajewole, Rodney Hunter, Yong-Fang Kuo, Susanne Schmidt, Monique R Pappadis, Elise Smith, Alex Bokov, Timothy Reistetter, Shyam Visweswaran, Brian Downer

J Med Internet Res 2025 (Feb 11); 27:e48775

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Trends and Gaps in Digital Precision Hypertension Management: Scoping Review

Namuun Clifford, Rachel Tunis, Adetimilehin Ariyo, Haoxiang Yu, Hyekyun Rhee, Kavita Radhakrishnan

J Med Internet Res 2025 (Feb 10); 27:e59841

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Identifying High-Priority Ethical Challenges for Precision Emergency Medicine: Nominal Group Study

Christian Rose, Emily Shearer, Isabela Woller, Ashley Foster, Nicholas Ashenburg, Ireh Kim, Jennifer Newberry

JMIR Form Res 2025 (Feb 06); 9:e68371

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Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study

Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

J Med Internet Res 2025 (Jan 30); 27:e67346

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Impact of Online Interactive Decision Tools on Women’s Decision-Making Regarding Breast Cancer Screening: Systematic Review and Meta-Analysis

Patricia Villain, Laura Downham, Alice Le Bonniec, Charlotte Bauquier, Olena Mandrik, Tom Nadarzynski, Lorie Donelle, Raúl Murillo, Eleni L Tolma, Sonali Johnson, Patricia Soler-Michel, Robert Smith

J Med Internet Res 2025 (Jan 29); 27:e65974

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Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

Bernard Friedenson

JMIRx Med 2025 (Jan 29); 6:e50712

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Evaluation of the Feasibility of Transfusing Leukocyte Depletion Filter–Processed Intraoperative Cell Salvage Blood in Metastatic Spine Tumor Surgery: Protocol for a Non–Randomized Study

Naresh Kumar, Si Jian Hui, Renick Lee, Sahil Athia, Joel Yong Hao Tan, Jonathan Jiong Hao Tan

JMIR Res Protoc 2025 (Jan 17); 14:e54609

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Building a Digital Health Research Platform to Enable Recruitment, Enrollment, Data Collection, and Follow-Up for a Highly Diverse Longitudinal US Cohort of 1 Million People in the All of Us Research Program: Design and Implementation Study

Dave Klein, Aisha Montgomery, Mark Begale, Scott Sutherland, Sherilyn Sawyer, Jacob L McCauley, Letheshia Husbands, Deepti Joshi, Alan Ashbeck, Marcy Palmer, Praduman Jain

J Med Internet Res 2025 (Jan 15); 27:e60189

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Effect of a Feedback Visit and a Clinical Decision Support System Based on Antibiotic Prescription Audit in Primary Care: Multiarm Cluster-Randomized Controlled Trial

Pauline Jeanmougin, Stéphanie Larramendy, Jean-Pascal Fournier, Aurélie Gaultier, Cédric Rat

J Med Internet Res 2024 (Dec 18); 26:e60535

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Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach

Phan Thanh Phuc, Phung-Anh Nguyen, Nam Nhat Nguyen, Min-Huei Hsu, Nguyen Quoc Khanh Le, Quoc-Viet Tran, Chih-Wei Huang, Hsuan-Chia Yang, Cheng-Yu Chen, Thi Anh Hoa Le, Minh Khoi Le, Hoang Bac Nguyen, Christine Y Lu, Jason C Hsu

J Med Internet Res 2024 (Dec 11); 26:e52107

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A 360° Approach to Personalize Lifestyle Treatment in Primary Care for People With Type 2 Diabetes: Feasibility Study

Zeena Harakeh, Iris de Hoogh, Anne-Margreeth Krijger-Dijkema, Susanne Berbée, Gino Kalkman, Pepijn van Empelen, Wilma Otten

JMIR Form Res 2024 (Dec 04); 8:e57312

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An Educational Digital Tool to Improve the Implementation of Switching to a Biosimilar (Rapid Switch Trainer): Tool Development and Validation Study

Carlos Marras, María Labarga, Daniel Ginard, Jose Manuel Carrascosa, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Fernando de Mora, Tamara Robles, Elisa Romero, Rafael Martínez

JMIR Form Res 2024 (Nov 21); 8:e56553

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Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review

David Drummond, Apolline Gonsard

J Med Internet Res 2024 (Nov 13); 26:e58504

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