Precision Medicine

Machine Learning Prediction Models for Preeclampsia: Systematic Review and Meta-Analysis

Lu Liu, Qixuan Zhu, Yichi Zong, Xueyuan Chen, Wei Zhang, Jun Wang

J Med Internet Res 2026 (Jan 19); 28:e78714

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Nomograms Based on X-Ray Radiomics for Predicting Pain Progression in Knee Osteoarthritis Using Data From the Foundation for the National Institutes of Health: Development and Validation Study

Yingwei Sun, Jing Liu, Chunbo Deng, Chengbao Peng, Shinong Pan, Xueyong Liu

JMIR Med Inform 2026 (Jan 14); 14:e78338

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Prognostic Value of Dynamic Lactate Dehydrogenase Trends in Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma: Retrospective Cohort Study

Baidong Zhang, Zhichao Kang, Yi Ding, Wang Jing, Alei Feng, Renya Zeng, Jianan Li, Yi Zhao, Yuanliu Nie, Wentao Zhang, Lu Sun, Zhe Yang

JMIR Cancer 2026 (Jan 14); 12:e73576

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The Role of Iron-Overloaded Macrophages in Mesenchymal Stem Cell Senescence and Anemia in Myelodysplastic Syndromes: Protocol for an In Vitro Study

Lu Bai, Fan Wang, Yaxian Jiang, Hongmei Ouyang

JMIR Res Protoc 2026 (Jan 13); 15:e77936

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Explainable AI for Predicting Mortality Risk in Metastatic Cancer: Retrospective Cohort Study Using the Memorial Sloan Kettering-Metastatic Dataset

Polycarp Nalela, Deepthi Rao, Praveen Rao

JMIR Cancer 2026 (Jan 13); 12:e74196

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Physical Activity Recommendations Tailored by a Predictive Model for Adults With High Blood Pressure: Observational Study

Yuhui Yang, Manqing Chen, Weiwei Hu, Yifan Fu, Xingyan Li, Zhenli Liao, Hongman Feng, Yaling Zhao, Leilei Pei, Baibing Mi, Fangyao Chen

J Med Internet Res 2026 (Jan 09); 28:e78492

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Technologies, Clinical Applications, and Implementation Barriers of Digital Twins in Precision Cardiology: Systematic Review

Fatemeh Sarani Rad, Ehsan Bitaraf, Maryam Jafarpour, Juan Li

JMIR Cardio 2026 (Jan 08); 10:e78499

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Automated Classification of Lymphoma Subtypes From Histopathological Images Using a U-Net Deep Learning Model: Comparative Evaluation Study

Jin Zhao, Xiaolian Wen, Li Ma, Liping Su

JMIR Med Inform 2026 (Jan 06); 14:e72679

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Automated Multitier Tagging of Chinese Online Health Education Resources Using a Large Language Model: Development and Validation Study

Jialin Meng, Ruiming Dai, Xiaolan Huang, Yi Gu, Shixing Yan, Xiaoke Wang, Jingrong Gao, Tian-Tian Zhang

J Med Internet Res 2025 (Dec 17); 27:e83219

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Accelerometer-Derived Rest-Activity Rhythm Amplitude, Genetic Predisposition, and the Risk of Ischemic Heart Disease: Observational and Mendelian Randomization Study

Lele Wang, Juying Zhang, Xiong Xiao, Xuewei Tang, Jianxiang Tang, Hao Xu, Bing Guo, Xing Zhao

J Med Internet Res 2025 (Dec 15); 27:e79301

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IL-6/GP130/JAK/STAT3 Pathway Activation in Pancreatic Ductal Adenocarcinoma and Its Association With Clinical Features: Protocol for a Retrospective Cross-Sectional Study

Claudia Mellenthin, Fabien Schaller, Lucie Vignot, Sarah Peisl, Rita Vesce, Irene Esposito, Carmen Gonelle-Gispert, Cornelia Schneider, Michel Adamina, Leo Hans Bühler

JMIR Res Protoc 2025 (Dec 15); 14:e76811

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Data Visualization Support for Interdisciplinary Team Treatment Planning in Clinical Oncology: Scoping Review

Dominik Boehm, Cosima Strantz, Arsenij Ustjanzew, Iryna Manuilova, Alexander Scheiter, Thomas Pauli, Nicole Hechtel, Niklas Reimer, Jan Christoph, Hauke Busch, Thomas Ganslandt, Philipp Unberath

J Med Internet Res 2025 (Dec 09); 27:e69104

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The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study

Jasmin Annica Kuhn-Keller, Ingmar Eiling, Lydiane Hirschler, Lena Václavů, Marie-Noëlle Witjes-Ané, Marjolein Wijngaarden, Martijn Nagtegaal, Ece Ercan, Nathaly Rius Ottenheim, Marjan van der Elst, Evelien Sohl, Mark A van Buchem, Simon Mooijaart, Matthias JP van Osch, Jeroen de Bresser

JMIR Res Protoc 2025 (Dec 04); 14:e77681

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Machine Learning–Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation

Samuel Kakraba, Srinivas Ayyadevara, Aayire Yadem Clement, Kuukua Egyinba Abraham, Cesar M Compadre, Robert J Shmookler Reis

JMIR AI 2025 (Dec 03); 4:e77890

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Decentralized Biobanking Pathway to Precision Medicine: Futures Study

Marielle Gross, Ananya Dewan, Kennedy Sabharwal, Amanda Linkous, M Eifler, William Sanchez, Robert Miller, Mario Macis, Joshua C Rubin

J Med Internet Res 2025 (Dec 01); 27:e73965

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Risk Prediction of Major Adverse Cardiovascular Events Within One Year After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: Machine Learning–Based Time-to-Event Analysis

Hong-Jae Choi, Changhee Lee, Hack-Lyoung Kim, Youn-Jung Son

JMIR Med Inform 2025 (Nov 27); 13:e81778

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Toward a Personalized Basal Tuner for Detecting Basal Rate Inaccuracies in Type 1 Diabetes Mellitus Without Meal Data: Algorithm Development and Retrospective Validation Study

Daniel Gasca Garcia, Hood Thabit, Paul W Nutter, Simon Harper

JMIR Diabetes 2025 (Nov 26); 10:e72769

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Effect of Dual-Task Training on Cognitive Function in Community-Dwelling Older Adults With Mild Cognitive Impairment: Sequential Multiple Assignment Randomized Trial

Chenhao Yu, Dongsheng Bian, Jiatao Zhang, Xiao Han, Chenshu Shi, Guohong Li

J Med Internet Res 2025 (Nov 25); 27:e79274

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Estimating 10-Year Cardiovascular Disease Risk in Primary Prevention Using UK Electronic Health Records and a Hybrid Multitask BERT Model: Retrospective Cohort Study

Tianyi Liu, Lei Lu, Yanzhong Wang, Andrew J Krentz, Vasa Curcin

JMIR Med Inform 2025 (Nov 13); 13:e76659

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Generative Models and Sentence Transformers for the Recognition and Normalization of Continuous and Discontinuous Phenotype Mentions: Model Development and Evaluation

Areej Alhassan, Viktor Schlegel, Monira Aloud, Riza Batista-Navarro, Goran Nenadic

JMIR Med Inform 2025 (Nov 05); 13:e68558

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