Complete Blood Count and Monocyte Distribution Width–Based Machine Learning Algorithms for Sepsis Detection: Multicentric Development and External Validation Study

Andrea Campagner   ^{1 *} , PhD ;   Luisa Agnello   ^{2 *} , PhD ;   Anna Carobene   ³ , PhD ;   Andrea Padoan   ^{4, 5} , Prof Dr ;   Fabio Del Ben   ⁶ , PhD ;   Massimo Locatelli   ³ , Dr med ;   Mario Plebani   ^{4, 5} , Prof Dr ;   Agostino Ognibene   ⁷ , Dr med ;   Maria Lorubbio   ⁷ , Dr med ;   Elena De Vecchi   ¹ , PhD ;   Andrea Cortegiani   ^{2, 8} , Prof Dr ;   Elisa Piva   ⁹ , Dr med ;   Donatella Poz   ¹⁰ , Dr med ;   Francesco Curcio   ¹⁰ , Prof Dr ;   Federico Cabitza   ^{1, 11 *} , Prof Dr ;   Marcello Ciaccio   ^{2, 8 *} , Prof Dr

¹ IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy

² University of Palermo, Palermo, Italy

³ IRCCS San Raffaele Scientific Institute, Milano, Italy

⁴ Department of Medicine, University of Padova, Padova, Italy

⁵ Laboratory Medicine Unit, University-Hospital of Padova, Padova, Italy

⁶ IRCCS Centro Di Riferimento Oncologico Aviano, Aviano, Italy

⁷ San Donato Hospital of Arezzo, Arezzo, Italy

⁸ University Hospital Policlinico Paolo Giaccone, Palermo, Italy

⁹ Azienda Socio Sanitaria Territoriale di Mantova, Mantova, Italy

¹⁰ University Hospital of Udine, Udine, Italy

¹¹ Department of Computer Science, Systems and Communication, University of Milano-Bicocca, Milano, Italy

*these authors contributed equally