Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study

Samer El Kababji   ^{1, 2} , PhD ;   Nicholas Mitsakakis   ² , MSc, PhD ;   Elizabeth Jonker   ² , BA ;   Ana-Alicia Beltran-Bless   ³ , MD ;   Gregory Pond   ⁴ , PhD ;   Lisa Vandermeer   ³ , MSc ;   Dhenuka Radhakrishnan   ² , MD ;   Lucy Mosquera   ⁵ , MSc ;   Alexander Paterson   ⁶ , MD ;   Lois Shepherd   ⁷ , MDCM, FRCP ;   Bingshu Chen   ⁷ , PhD ;   William Barlow   ⁸ , PhD ;   Julie Gralow   ⁹ , MD ;   Marie-France Savard   ³ , MD ;   Christian Fesl   ¹⁰ , PhD ;   Dominik Hlauschek   ¹⁰ , MSc ;   Marija Balic   ¹¹ , MD, PhD ;   Gabriel Rinnerthaler   ¹¹ , MD ;   Richard Greil   ¹² , MD ;   Michael Gnant   ¹³ , MD ;   Mark Clemons   ³ , MD ;   Khaled El Emam   ^{1, 2} , BEng, PhD

¹ School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

² CHEO Research Institute, Ottawa, ON, Canada

³ Division of Medical Oncology, University of Ottawa, Ottawa, ON, Canada

⁴ Department of Oncology, McMaster University, Hamilton, ON, Canada

⁵ Generate Ops & Data Science, Aetion, Ottawa, ON, Canada

⁶ Oncology, Alberta Health Services, Edmonton, AB, Canada

⁷ Public Health Sciences, Queens University, Kingston, ON, Canada

⁸ Biostatistics, University of Washington, Seattle, WA, United States

⁹ Medical Oncology, University of Washington, Seattle, WA, United States

¹⁰ Clinical Statistics, Austrian Breast & Colorectal Cancer Study Group (ABCSG), Vienna, Austria

¹¹ Division of Clinical Oncology, Medical University Graz, Graz, Austria

¹² Paracelsus Medical University Salzburg, Salzburg, Austria

¹³ Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria