Enhancing Patient Selection in Sepsis Clinical Trials Design Through an AI Enrichment Strategy: Algorithm Development and Validation

Meicheng Yang   ^{1 *} , PhD ;   Jinqiang Zhuang   ^{2, 3 *} , MD ;   Wenhan Hu   ⁴ , PhD ;   Jianqing Li   ^{1, 5} , PhD ;   Yu Wang   ³ , MD ;   Zhongheng Zhang   ⁶ , MD ;   Chengyu Liu   ¹ , PhD ;   Hui Chen   ⁴ , MD

¹ State Key Laboratory of Digital Medical Engineering, School of Instrument Science and Engineering, Southeast University, Nanjing, China

² Emergency Intensive Care Unit (EICU), The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China

³ Key Laboratory of Big Data Analysis and Knowledge Services of Yangzhou City, Yangzhou University, Yangzhou, China

⁴ Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China

⁵ School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China

⁶ Department of Emergency Medicine, Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

*these authors contributed equally