Cerebral Microbleeds in Different Brain Regions and Their Associations With the Digital Clock-Drawing Test: Secondary Analysis of the Framingham Heart Study

Samia C Akhter-Khan   ^{1, 2 *} , MSc ;   Qiushan Tao   ^{2, 3 *} , MSc, MD ;   Ting Fang Alvin Ang   ^{2, 4, 5, 6 *} , MD ;   Cody Karjadi   ^{2, 4} , MSc ;   Indira Swetha Itchapurapu   ³ , MPH ;   David J Libon   ^{7, 8} , PhD ;   Michael Alosco   ^{9, 10} , PhD ;   Jesse Mez   ^{2, 9, 10} , MSc, MD ;   Wei Qiao Qiu   ^{2, 3, 10, 11} , MD, PhD ;   Rhoda Au   ^{2, 4, 5, 6, 9, 10} , PhD

¹ Department of Global Health & Social Medicine, King's College London, London, United Kingdom

² Framingham Heart Study, Boston University School of Medicine, Boston, MA, United States

³ Pharmacology, Physiology & Biophysics, Boston University School of Medicine, Boston, MA, United States

⁴ Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, United States

⁵ Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States

⁶ Slone Epidemiology Center, Boston University School of Medicine, Boston, MA, United States

⁷ Department of Geriatrics and Gerontology, Rowan University, Glassboro, NJ, United States

⁸ Department of Psychology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, Glassboro, NJ, United States

⁹ Department of Neurology, Boston University School of Medicine, Boston, MA, United States

¹⁰ Alzheimer’s Disease and Chronic Traumatic Encephalopathy Centers, Boston University, Boston, MA, United States

¹¹ Department of Psychiatry, Boston University School of Medicine, Boston, MA, United States

*these authors contributed equally