Machine Learning Analysis of Time-Dependent Features for Predicting Adverse Events During Hemodialysis Therapy: Model Development and Validation Study

Yi-Shiuan Liu   ^{1, 2, 3, 4} , PhD ;   Chih-Yu Yang   ^{1, 2, 5, 6 *} , MD, PhD ;   Ping-Fang Chiu   ⁷ , MD ;   Hui-Chu Lin   ² , MS ;   Chung-Chuan Lo   ⁸ , PhD ;   Alan Szu-Han Lai   ² , BS ;   Chia-Chu Chang   ^{9, 10} , MD, PhD ;   Oscar Kuang-Sheng Lee   ^{1, 2, 11 *} , MD, PhD

¹ Institute of Clinical Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan

² Stem Cell Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan

³ Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan

⁴ Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

⁵ Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

⁶ Center for Intelligent Drug Systems and Smart Bio-devices, Hsinchu, Taiwan

⁷ Division of Nephrology, Department of Medicine, Changhua Christian Hospital, Changhua, Taiwan

⁸ Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu, Taiwan

⁹ Department of Medicine, Kuang Tien General Hospital, Taichung, Taiwan

¹⁰ Department of Nutrition, Hungkuang University, Taichung, Taiwan

¹¹ Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan

*these authors contributed equally