Personalized Risk Analysis to Improve the Psychological Resilience of Women Undergoing Treatment for Breast Cancer: Development of a Machine Learning–Driven Clinical Decision Support Tool

Georgios C Manikis   ^{1 *} , PhD ;   Nicholas J Simos   ^{1 *} , MSc ;   Konstantina Kourou   ^{2, 3} , PhD ;   Haridimos Kondylakis   ¹ , PhD ;   Paula Poikonen-Saksela   ⁴ , MD, PhD ;   Ketti Mazzocco   ^{5, 6} , Prof Dr ;   Ruth Pat-Horenczyk   ⁷ , Prof Dr ;   Berta Sousa   ⁸ , MD ;   Albino J Oliveira-Maia   ⁹ , MPH, MD, PhD ;   Johanna Mattson   ⁴ , Prof Dr ;   Ilan Roziner   ¹⁰ , PhD ;   Chiara Marzorati   ⁵ , PhD ;   Kostas Marias   ¹ , Prof Dr ;   Mikko Nuutinen   ¹¹ , PhD ;   Evangelos Karademas   ¹ , Prof Dr ;   Dimitrios Fotiadis   ^{2, 3} , Prof Dr

¹ Foundation for Research and Technology-Hellas, Institute of Computer Science, Heraklion, Greece

² Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece

³ Foundation for Research and Technology-Hellas, Biomedical Research Institute, Ioannina, Greece

⁴ Comprehensive Cancer Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

⁵ Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy

⁶ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

⁷ School of Social Work and Social Welfare,The Hebrew University of Jerusalem, Jerusalem, Israel

⁸ Breast Unit, Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal

⁹ Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal

¹⁰ Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

¹¹ Nordic Healthcare Group, Helsinkifin, Finland

*these authors contributed equally