A Remote Digital Monitoring Platform to Assess Cognitive and Motor Symptoms in Huntington Disease: Cross-sectional Validation Study

Florian Lipsmeier   ¹ , PhD ;   Cedric Simillion   ¹ , PhD ;   Atieh Bamdadian   ¹ , PhD ;   Rosanna Tortelli   ² , MD ;   Lauren M Byrne   ² , PhD ;   Yan-Ping Zhang   ¹ , PhD ;   Detlef Wolf   ¹ , MSc ;   Anne V Smith   ³ , PhD ;   Christian Czech   ^{1, 4} , PhD ;   Christian Gossens   ¹ , PhD ;   Patrick Weydt   ^{5, 6} , MD ;   Scott A Schobel   ⁷ , MD ;   Filipe B Rodrigues   ² , MD ;   Edward J Wild   ² , PhD ;   Michael Lindemann   ¹ , PhD

¹ Roche Pharma Research and Early Development, pRED Informatics, Pharmaceutical Sciences, Clinical Pharmacology, and Neuroscience, Ophthalmology, and Rare Diseases Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

² Huntington’s Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

³ Ionis Pharmaceuticals Inc, Carlsbad, CA, United States

⁴ Rare Disease Research Unit, Pfizer, Nice, France

⁵ Department of Neurology, University of Ulm Medical Center, Ulm, Germany

⁶ Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn Medical Center, Bonn, Germany

⁷ F. Hoffmann-La Roche Ltd, Basel, Switzerland