Associations Between the Digital Clock Drawing Test and Brain Volume: Large Community-Based Prospective Cohort (Framingham Heart Study)

Jing Yuan   ^{1, 2} , MD ;   Rhoda Au   ^{2, 3, 4, 5, 6, 7} , MBA, PhD ;   Cody Karjadi   ^{2, 3} , MSc ;   Ting Fang Ang   ^{2, 3, 6} , MD, MPH ;   Sherral Devine   ^{2, 3} , PhD ;   Sanford Auerbach   ^{3, 4} , MD ;   Charles DeCarli   ⁸ , MD, FAAN, FAHA ;   David J Libon   ⁹ , PhD ;   Jesse Mez   ^{3, 4, 7} , MSc, MD ;   Honghuang Lin   ¹⁰ , PhD

¹ Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

² Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston University, Boston, MA, United States

³ Framingham Heart Study, Boston University School of Medicine, Boston University, Boston, MA, United States

⁴ Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, United States

⁵ Department of Epidemiology, Boston University School of Public Health, Boston University, Boston, MA, United States

⁶ Slone Epidemiology Center, Boston University School of Medicine, Boston University, Boston, MA, United States

⁷ Alzheimer’s Disease Research Center, Boston University, Boston, MA, United States

⁸ Department of Neurology and Center for Neuroscience, University of California, Davis, Sacramento, CA, United States

⁹ Department of Geriatrics and Gerontology and Department of Psychology, New Jersey Institute for Successful Aging, Rowan University, School of Osteopathic Medicine, Stratford, NJ, United States

¹⁰ Division of Clinical Informatics, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States