Comparisons Between Hypothesis- and Data-Driven Approaches for Multimorbidity Frailty Index: A Machine Learning Approach

Li-Ning Peng   ^{1, 2, 3 *} , MD, PhD ;   Fei-Yuan Hsiao   ^{4, 5, 6 *} , PhD ;   Wei-Ju Lee   ^{1, 2, 3, 7} , MD, PhD ;   Shih-Tsung Huang   ⁴ , PharmD, MS ;   Liang-Kung Chen   ^{1, 2, 3} , MD, PhD

¹ Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan

² Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan

³ Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan

⁴ Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan

⁵ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan

⁶ Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan

⁷ Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan, Taiwan

*these authors contributed equally