Randomized trials (Editor: G. Eysenbach)*

Articles published in this theme: 50 (scroll down to load remaining articles)

2026

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Effectiveness of the Components of a Digital Multiple Health Behavior Change Intervention Among Individuals Seeking Help Online (Coach): Factorial Randomized Trial

Joel Crawford, Katarina Åsberg, Jenny Blomqvist, Oskar Lundgren, Hanna Henriksson, Pontus Henriksson, Preben Bendtsen, Marie Löf, Marcus Bendtsen

J Med Internet Res 2026 (Apr 02); 28:e88881

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2025

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AI-Driven Tacrolimus Dosing in Transplant Care: Cohort Study

Mingjia Huo, Sean Perez, Linda Awdishu, Janice S Kerr, Pengtao Xie, Adnan Khan, Kristin Mekeel, Shamim Nemati

JMIR AI 2025 (Sep 02); 4:e67302

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Authors’ Response to Peer Reviews of “Rapidly Benchmarking Large Language Models for Diagnosing Comorbid Patients: Comparative Study Leveraging the LLM-as-a-Judge Method”

Peter Sarvari, Zaid Al-fagih

JMIRx Med 2025 (Aug 29); 6:e81235

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Authors’ Response to Peer Review of “Use of Mobile Forms in Low-Resource Areas for Population Health Surveys: Interview and Field Test Study”

Alexander Davis, Aidan Chen, Milton Chen, James Davis

JMIRx Med 2025 (Aug 11); 6:e79539

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Effectiveness of Smart Continence Care for People With Profound Intellectual and Multiple Disabilities: Cluster Randomized Trial

Vivette JC van Cooten, Marieke FM Gielissen, Wouter den Hollander, Ghislaine APG van Mastrigt, Odile Smeets, Inge MB Bongers, Brigitte Boon

J Med Internet Res 2025 (Jul 31); 27:e66389

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Authors’ Response to Peer Review of “Using Electrooculography and Electrodermal Activity During a Cold Pressor Test to Identify Physiological Biomarkers of State Anxiety: Feature-Based Algorithm Development and Validation Study”

Jadelynn Dao, Ruixiao Liu, Sarah Solomon, Samuel Aaron Solomon

JMIRx Med 2025 (Jul 10); 6:e77440

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Boosting Blood Donations Through Facebook Engagement: Randomized Controlled Field Trial

Steven Ramondt, Peter Kerkhof, Eva-Maria Merz

J Med Internet Res 2025 (May 12); 27:e64740

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Impact of a Symptom Checker App on Patient-Physician Interaction Among Self-Referred Walk-In Patients in the Emergency Department: Multicenter, Parallel-Group, Randomized, Controlled Trial

Malte L Schmieding, Marvin Kopka, Myrto Bolanaki, Hendrik Napierala, Maria B Altendorf, Doreen Kuschick, Sophie K Piper, Lennart Scatturin, Konrad Schmidt, Claudia Schorr, Alica Thissen, Cornelia Wäscher, Christoph Heintze, Martin Möckel, Felix Balzer, Anna Slagman

J Med Internet Res 2025 (Apr 02); 27:e64028

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Design and Baseline Evaluation of Social Media Vaping Prevention Trial: Randomized Controlled Trial Study

William Douglas Evans, Megumi Ichimiya, Jeffrey B Bingenheimer, Jennifer Cantrell, Alexander P D'Esterre, Olivia Pincus, Linda Q Yu, Elizabeth C Hair

J Med Internet Res 2025 (Mar 31); 27:e72002

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Effectiveness of the Safe Step Digital Exercise Program to Prevent Falls in Older Community-Dwelling Adults: Randomized Controlled Trial

Beatrice Pettersson, Lillemor Lundin-Olsson, Dawn A Skelton, Per Liv, Magnus Zingmark, Erik Rosendahl, Marlene Sandlund

J Med Internet Res 2025 (Mar 31); 27:e67539

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Acceptability and Effectiveness of a Fully Web-Based Nutrition and Exercise Program for Individuals With Chronic Disease During COVID-19: Randomized Controlled Trial

Puneeta Tandon, Kathleen P Ismond, Graeme Purdy, Christofer Cruz, Evelyn Etruw, Kirsten Suderman, Ashley Hyde, Michael Stickland, John C Spence, Dale C Lien, Rahima Bhanji, Carla M Prado, Antonio Miguel-Cruz, Anil A Joy, Maryna Yaskina, Margaret L McNeely

J Med Internet Res 2025 (Mar 24); 27:e57537

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Authors’ Response to Peer Reviews of “Large Language Models for Pediatric Differential Diagnoses in Rural Health Care: Multicenter Retrospective Cohort Study Comparing GPT-3 With Pediatrician Performance”

Masab Mansoor, Andrew F Ibrahim, David Grindem, Asad Baig

JMIRx Med 2025 (Mar 19); 6:e73258

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Alternative Presentations of Overall and Statistical Uncertainty for Adults’ Understanding of the Results of a Randomized Trial of a Public Health Intervention: Parallel Web-Based Randomized Trials

Christine Holst, Steven Woloshin, Andrew D Oxman, Christopher Rose, Sarah Rosenbaum, Heather Menzies Munthe-Kaas

JMIR Public Health Surveill 2025 (Mar 18); 11:e62828

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Optimizing Engagement With a Smartphone App to Prevent Violence Against Adolescents: Results From a Cluster Randomized Factorial Trial in Tanzania

Roselinde Janowski, Lucie D Cluver, Yulia Shenderovich, Joyce Wamoyi, Mwita Wambura, David Stern, Lily Clements, G J Melendez-Torres, Lauren Baerecke, Abigail Ornellas, Angelique Nicole Chetty, Jonathan Klapwijk, Laetitia Christine, Ateamate Mukabana, Esmee Te Winkel, Anna Booij, Gervas Mbosoli, Jamie M Lachman

J Med Internet Res 2025 (Mar 10); 27:e60102

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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial

Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

J Med Internet Res 2025 (Jan 31); 27:e59946

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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial

Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

J Med Internet Res 2025 (Jan 21); 27:e56039

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2024

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Efficacy of Save Medical Corporation (SMC)–01, a Smartphone App Designed to Support Type 2 Diabetes Self-Management Based on Established Guidelines: Randomized Controlled Trial

Nicholas Leung, Kayo Waki, Satoshi Nozoe, Shunpei Enomoto, Ryo Saito, Sakurako Hamagami, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe, Yukiko Onishi

J Med Internet Res 2024 (Sep 10); 26:e53740

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Association of Remote Patient-Reported Outcomes and Step Counts With Hospitalization or Death Among Patients With Advanced Cancer Undergoing Chemotherapy: Secondary Analysis of the PROStep Randomized Trial

Christopher R Manz, Emily Schriver, William J Ferrell, Joelle Williamson, Jonathan Wakim, Neda Khan, Michael Kopinsky, Mohan Balachandran, Jinbo Chen, Mitesh S Patel, Samuel U Takvorian, Lawrence N Shulman, Justin E Bekelman, Ian J Barnett, Ravi B Parikh

J Med Internet Res 2024 (May 17); 26:e51059

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2023

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The Effect of Interactivity, Tailoring, and Use Intensity on the Effectiveness of an Internet-Based Smoking Cessation Intervention Over a 12-Month Period: Randomized Controlled Trial

Phillip Maiwald, Martina Bischoff, Peter Lindinger, Iris Tinsel, Matthias Sehlbrede, Urs Alexander Fichtner, Gloria Metzner, Christian Schlett, Erik Farin-Glattacker

J Med Internet Res 2023 (Nov 21); 25:e47463

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Effectiveness of a Theory-Based Digital Animated Video Intervention to Reduce Intention and Willingness to Sext Among Diploma Students: Cluster Randomized Controlled Trial

Norain Mansor, Norliza Ahmad, Salmiah Md Said, Kit-Aun Tan, Rosnah Sutan

J Med Internet Res 2023 (Oct 20); 25:e48968

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