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SARS-Co V-2 primarily uses the tissue-specific proteases TMPRSS2, TMPRSS4, and TMPRSS11 D as cellular entry factors via angiotensin-converting enzyme 2 channels, which are richly expressed in the tonsil crypts [18,19]. This may explain why SARS-Co V-2 can be detected in throat swabs before nasal swabs, underlining timing as a crucial factor for test results [20].
JMIR Res Protoc 2024;13:e47446
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