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Prevalence and Correlates of Clinically Elevated Depressive Symptoms in a Nationwide Sample of Transgender, Nonbinary, and Gender Diverse Young Adults in the United States: Cross-Sectional Survey Study

Prevalence and Correlates of Clinically Elevated Depressive Symptoms in a Nationwide Sample of Transgender, Nonbinary, and Gender Diverse Young Adults in the United States: Cross-Sectional Survey Study

Transgender, nonbinary, and gender diverse (TGD) young adults in the United States have a two- to four-fold higher risk of major depression [8] and are more likely to screen positive for clinically elevated depressive symptoms relative to their cisgender counterparts [9]. For example, in a national random sample of 65,231 college students drawn from 71 US college campuses, the prevalence of past 2-week depression using PHQ-9 was 57.8% for TGD young adults compared to 28.4% for cisgender young adults [9].

Sari Reisner, Yuxin Liu, Regina Tham, Kaiden Kane, S Wilson Cole, Elizabeth R Boskey, Sabra L Katz-Wise, Alex S Keuroghlian, Rena Xu

Interact J Med Res 2025;14:e66630

Introducing Novel Methods to Identify Fraudulent Responses (Sampling With Sisyphus): Web-Based LGBTQ2S+ Mixed-Methods Study

Introducing Novel Methods to Identify Fraudulent Responses (Sampling With Sisyphus): Web-Based LGBTQ2S+ Mixed-Methods Study

Participants were also asked a series of questions about whether, after stopping or reversing transition, they understand themselves as transgender, nonbinary, cisgender, or detransitioned (the response options were “yes,” “no,” and “unsure”). These questions were not mutually exclusive. We used community-engaged research strategies. The survey was reviewed for language accuracy by an English-speaking person in the United States with experience of detransition who received a gift card valued at US $150.

Kinnon Ross MacKinnon, Naail Khan, Katherine M Newman, Wren Ariel Gould, Gin Marshall, Travis Salway, Annie Pullen Sansfaçon, Hannah Kia, June SH Lam

J Med Internet Res 2025;27:e63252

Gender-Inclusive Language in Public-Facing Labor and Delivery Web Pages in the New York Tristate Area: Cross-Sectional Study

Gender-Inclusive Language in Public-Facing Labor and Delivery Web Pages in the New York Tristate Area: Cross-Sectional Study

Within the last 2 decades, as transgender and nonbinary (TGNB) people have gained greater legal and social recognition, those in the TGNB community who want to become pregnant have become increasingly more common, as have the number of families with same-sex, transgender, or nonbinary parents [1].

Sarah Mohsen Isaac, Mark Dawes, Emily Ruth Howell, Antonia Francis Oladipo

JMIR Hum Factors 2025;12:e53057

Examining TikTok’s Potential for Community-Engaged Digital Knowledge Mobilization With Equity-Seeking Groups

Examining TikTok’s Potential for Community-Engaged Digital Knowledge Mobilization With Equity-Seeking Groups

As an example, significant controversy erupted in 2019 when a researcher published a controversial study that presented a medically unsubstantiated term, rapid-onset gender dysphoria, arguing that trans and nonbinary (trans) identity is a social and peer contagion [2]. In response, several trans-identified community-engaged researchers challenged these findings on Twitter to draw attention to the study’s methodological flaws and its potential harm to trans-people [3-5].

Kinnon Ross MacKinnon, Hannah Kia, Ashley Lacombe-Duncan

J Med Internet Res 2021;23(12):e30315