The Effect of Internet-Based Cognitive Behavioral Therapy on Major Depressive Disorder: Randomized Controlled Trial

Ziyi Lin   ^{1, 2, 3 *} , MPH ;   Lu Cheng   ^{4 *} , PhD ;   Xue Han   ⁴ , PhD ;   Hongqiong Wang   ^{1, 2, 3} , MPhil ;   Yuhua Liao   ^{1, 2, 3, 4} , PhD ;   Lan Guo   ^{1, 2, 3} , MD, PhD ;   Jingman Shi   ^{1, 2, 3} , PhD ;   Beifang Fan   ⁴ , MD ;   Kayla M Teopiz   ⁵ , PhD ;   Muhammad Youshay Jawad   ^{6, 7} , PhD ;   Huimin Zhang   ⁴ , PhD ;   Yan Chen   ⁴ , MS ;   Ciyong Lu   ^{1, 2, 3} , MD, PhD ;   Roger S McIntyre   ^{5, 7, 8} , MD

¹ Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China

² Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangzhou, China

³ Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, China

⁴ Department of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China

⁵ Brain and Cognition Discovery Foundation, Toronto, ON, Canada

⁶ Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada

⁷ Department of Pharmacology, University of Toronto, Toronto, ON, Canada

⁸ Department of Psychiatry, University of Toronto, Toronto, ON, Canada

*these authors contributed equally