Preprints (earlier versions) of this paper are available at, first published .
Assessing the Efficacy of Mobile Health Apps Using the Basic Principles of Cognitive Behavioral Therapy: Systematic Review

Assessing the Efficacy of Mobile Health Apps Using the Basic Principles of Cognitive Behavioral Therapy: Systematic Review

Assessing the Efficacy of Mobile Health Apps Using the Basic Principles of Cognitive Behavioral Therapy: Systematic Review


  1. Yin H, Wardenaar K, Wang Y, Wang N, Chen W, Zhang Y, Xu G, Schoevers R. Mobile Mental Health Apps in China: Systematic App Store Search. Journal of Medical Internet Research 2020;22(7):e14915 View
  2. Sezgin E, Militello L, Huang Y, Lin S. A scoping review of patient-facing, behavioral health interventions with voice assistant technology targeting self-management and healthy lifestyle behaviors. Translational Behavioral Medicine 2020;10(3):606 View
  3. Magee J, Adut S, Brazill K, Warnick S. Mobile App Tools for Identifying and Managing Mental Health Disorders in Primary Care. Current Treatment Options in Psychiatry 2018;5(3):345 View
  4. Inkster B, Sarda S, Subramanian V. An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study. JMIR mHealth and uHealth 2018;6(11):e12106 View
  5. Schuster R, Kalthoff I, Walther A, Köhldorfer L, Partinger E, Berger T, Laireiter A. Effects, Adherence, and Therapists’ Perceptions of Web- and Mobile-Supported Group Therapy for Depression: Mixed-Methods Study. Journal of Medical Internet Research 2019;21(5):e11860 View
  6. Mak W, Tong A, Yip S, Lui W, Chio F, Chan A, Wong C. Efficacy and Moderation of Mobile App–Based Programs for Mindfulness-Based Training, Self-Compassion Training, and Cognitive Behavioral Psychoeducation on Mental Health: Randomized Controlled Noninferiority Trial. JMIR Mental Health 2018;5(4):e60 View
  7. Muroff J, Robinson W. Tools of Engagement: Practical Considerations for Utilizing Technology-Based Tools in CBT Practice. Cognitive and Behavioral Practice 2022;29(1):81 View
  8. McKay D. Introduction to the Special Issue: Integration of Technological Advances in Cognitive-Behavior Therapy. Behavior Therapy 2018;49(6):851 View
  9. Powell J. Trust Me, I’m a Chatbot: How Artificial Intelligence in Health Care Fails the Turing Test. Journal of Medical Internet Research 2019;21(10):e16222 View
  10. Ha S, Kim J. Designing a Scalable, Accessible, and Effective Mobile App Based Solution for Common Mental Health Problems. International Journal of Human–Computer Interaction 2020;36(14):1354 View
  11. Parmar N, Dong L, Eisingerich A. Connecting With Your Dentist on Facebook: Patients’ and Dentists’ Attitudes Towards Social Media Usage in Dentistry. Journal of Medical Internet Research 2018;20(6):e10109 View
  12. Bjornstad G, Sonthalia S, Rouse B, Timmons L, Whybra L, Axford N. PROTOCOL: A comparison of the effectiveness of cognitive behavioural interventions based on delivery features for elevated symptoms of depression in adolescents. Campbell Systematic Reviews 2020;16(1) View
  13. Marciniak M, Shanahan L, Rohde J, Schulz A, Wackerhagen C, Kobylińska D, Tuescher O, Binder H, Walter H, Kalisch R, Kleim B. Standalone Smartphone Cognitive Behavioral Therapy–Based Ecological Momentary Interventions to Increase Mental Health: Narrative Review. JMIR mHealth and uHealth 2020;8(11):e19836 View
  14. Porras-Segovia A, Díaz-Oliván I, Gutiérrez-Rojas L, Dunne H, Moreno M, Baca-García E. Apps for Depression: Are They Ready to Work?. Current Psychiatry Reports 2020;22(3) View
  15. O’Brien T, Russell C, Tan A, Washington M, Hathaway D. An Exploratory Correlational Study in the Use of Mobile Technology Among Adult Kidney Transplant Recipients. Progress in Transplantation 2018;28(4):368 View
  16. Austin S, Jansen J, Petersen C, Jensen R, Simonsen E. Mobile App Integration Into Dialectical Behavior Therapy for Persons With Borderline Personality Disorder: Qualitative and Quantitative Study. JMIR Mental Health 2020;7(6):e14913 View
  17. Person H, Keefer L. Brain-Gut Therapies for Pediatric Functional Gastrointestinal Disorders and Inflammatory Bowel Disease. Current Gastroenterology Reports 2019;21(4) View
  18. Alwashmi M, Fitzpatrick B, Davis E, Farrell J, Gamble J, Hawboldt J. Features of a mobile health intervention to manage chronic obstructive pulmonary disease: a qualitative study. Therapeutic Advances in Respiratory Disease 2020;14:175346662095104 View
  19. Tark R, Metelitsa M, Akkermann K, Saks K, Mikkel S, Haljas K. Usability, Acceptability, Feasibility, and Effectiveness of a Gamified Mobile Health Intervention (Triumf) for Pediatric Patients: Qualitative Study. JMIR Serious Games 2019;7(3):e13776 View
  20. Low D, Bentley K, Ghosh S. Automated assessment of psychiatric disorders using speech: A systematic review. Laryngoscope Investigative Otolaryngology 2020;5(1):96 View
  21. Flett J, Conner T, Riordan B, Patterson T, Hayne H. App-based mindfulness meditation for psychological distress and adjustment to college in incoming university students: a pragmatic, randomised, waitlist-controlled trial. Psychology & Health 2020;35(9):1049 View
  22. Rabbi M, Aung M, Gay G, Reid M, Choudhury T. Feasibility and Acceptability of Mobile Phone–Based Auto-Personalized Physical Activity Recommendations for Chronic Pain Self-Management: Pilot Study on Adults. Journal of Medical Internet Research 2018;20(10):e10147 View
  23. Silva Almodovar A, Surve S, Axon D, Cooper D, Nahata M. Self-Directed Engagement with a Mobile App (Sinasprite) and Its Effects on Confidence in Coping Skills, Depression, and Anxiety: Retrospective Longitudinal Study. JMIR mHealth and uHealth 2018;6(3):e64 View
  24. Purkayastha S, Addepally S, Bucher S. Engagement and Usability of a Cognitive Behavioral Therapy Mobile App Compared With Web-Based Cognitive Behavioral Therapy Among College Students: Randomized Heuristic Trial. JMIR Human Factors 2020;7(1):e14146 View
  25. Rowland S, Fitzgerald J, Holme T, Powell J, McGregor A. What is the clinical value of mHealth for patients?. npj Digital Medicine 2020;3(1) View
  26. Mehrotra S, Tripathi R. Recent developments in the use of smartphone interventions for mental health. Current Opinion in Psychiatry 2018;31(5):379 View
  27. Mehrotra S, Sudhir P, Rao G, Thirthalli J, Srikanth T. Development and Pilot Testing of an Internet-Based Self-Help Intervention for Depression for Indian Users. Behavioral Sciences 2018;8(4):36 View
  28. Militello L, Hanna N, Nigg C. Pokémon GO Within the Context of Family Health: Retrospective Study. JMIR Pediatrics and Parenting 2018;1(2):e10679 View
  29. Colombo D, Fernández-Álvarez J, García Palacios A, Cipresso P, Botella C, Riva G. New Technologies for the Understanding, Assessment, and Intervention of Emotion Regulation. Frontiers in Psychology 2019;10 View
  30. Deady M, Glozier N, Calvo R, Johnston D, Mackinnon A, Milne D, Choi I, Gayed A, Peters D, Bryant R, Christensen H, Harvey S. Preventing depression using a smartphone app: a randomized controlled trial. Psychological Medicine 2022;52(3):457 View
  31. Lin Y, Tudor-Sfetea C, Siddiqui S, Sherwani Y, Ahmed M, Eisingerich A. Effective Behavioral Changes through a Digital mHealth App: Exploring the Impact of Hedonic Well-Being, Psychological Empowerment and Inspiration. JMIR mHealth and uHealth 2018;6(6):e10024 View
  32. Hussain-Shamsy N, Shah A, Vigod S, Zaheer J, Seto E. Mobile Health for Perinatal Depression and Anxiety: Scoping Review. Journal of Medical Internet Research 2020;22(4):e17011 View
  33. Huckvale K, Nicholas J, Torous J, Larsen M. Smartphone apps for the treatment of mental health conditions: status and considerations. Current Opinion in Psychology 2020;36:65 View
  34. Lévi F, Komarzynski S, Huang Q, Young T, Ang Y, Fuller C, Bolborea M, Brettschneider J, Fursse J, Finkenstädt B, White D, Innominato P. Tele-Monitoring of Cancer Patients’ Rhythms during Daily Life Identifies Actionable Determinants of Circadian and Sleep Disruption. Cancers 2020;12(7):1938 View
  35. Callan J, Dunbar Jacob J, Siegle G, Dey A, Thase M, DeVito Dabbs A, Kazantzis N, Rotondi A, Tamres L, Van Slyke A, Sereika S. CBT MobileWork©: User-Centered Development and Testing of a Mobile Mental Health Application for Depression. Cognitive Therapy and Research 2021;45(2):287 View
  36. Rauseo-Ricupero N, Torous J. Technology Enabled Clinical Care (TECC): Protocol for a Prospective Longitudinal Cohort Study of Smartphone-Augmented Mental Health Treatment. JMIR Research Protocols 2021;10(1):e23771 View
  37. Kulakli A, Shubina I. Scientific Publication Patterns of Mobile Technologies and Apps for Posttraumatic Stress Disorder Treatment: Bibliometric Co-Word Analysis. JMIR mHealth and uHealth 2020;8(11):e19391 View
  38. Prescott J, Rathbone A, Brown G. Online peer to peer support: Qualitative analysis of UK and US open mental health Facebook groups. DIGITAL HEALTH 2020;6:205520762097920 View
  39. Bahadoor R, Alexandre J, Fournet L, Gellé T, Serre F, Auriacombe M. Inventory and Analysis of Controlled Trials of Mobile Phone Applications Targeting Substance Use Disorders: A Systematic Review. Frontiers in Psychiatry 2021;12 View
  40. Bientzle M, Restle A, Kimmerle J. Perception of Purposeful and Recreational Smartphone Use in Physiotherapy: Randomized Controlled Trial. JMIR mHealth and uHealth 2021;9(4):e25717 View
  41. Thornton L, Gardner L, Osman B, Green O, Champion K, Bryant Z, Teesson M, Kay-Lambkin F, Chapman C. A Multiple Health Behavior Change, Self-Monitoring Mobile App for Adolescents: Development and Usability Study of the Health4Life App. JMIR Formative Research 2021;5(4):e25513 View
  42. Hunt M, Miguez S, Dukas B, Onwude O, White S. Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial. JMIR mHealth and uHealth 2021;9(5):e26152 View
  43. Martinengo L, Stona A, Griva K, Dazzan P, Pariante C, von Wangenheim F, Car J. Self-guided Cognitive Behavioral Therapy Apps for Depression: Systematic Assessment of Features, Functionality, and Congruence With Evidence. Journal of Medical Internet Research 2021;23(7):e27619 View
  44. Amorim P, Paulo J, Silva P, Peixoto P, Castelo-Branco M, Martins H. Machine Learning Applied to Low Back Pain Rehabilitation – A Systematic Review. International Journal of Digital Health 2021;1(1):10 View
  45. Oliveira C, Pereira A, Vagos P, Nóbrega C, Gonçalves J, Afonso B. Effectiveness of Mobile App-Based Psychological Interventions for College Students: A Systematic Review of the Literature. Frontiers in Psychology 2021;12 View
  46. McCall T, Ali M, Yu F, Fontelo P, Khairat S. Development of a Mobile App to Support Self-management of Anxiety and Depression in African American Women: Usability Study. JMIR Formative Research 2021;5(8):e24393 View
  47. Anna Marciniak M, Shanahan L, Rohde J, Ehrt Y, Schulz A, Wackerhagen C, Kobylińska D, Tüscher O, Binder H, Walter H, Kalisch R, Kleim B. Stand-Alone KVT-basierte Interventionen via Smartphone zur Förderung der psychischen Gesundheit. Nervenheilkunde 2021;40(07):558 View
  48. Brown G, Rathbone A, Prescott J. Social media use for supporting mental health (SMILE). Mental Health Review Journal 2021;26(3):279 View
  49. Reyes A. The Process of Learning Mindfulness and Acceptance through the Use of a Mobile App Based on Acceptance and Commitment Therapy: A Grounded Theory Analysis. Issues in Mental Health Nursing 2022;43(1):3 View
  50. Badesha K, Wilde S, Dawson D. Mental health mobile app use to manage psychological difficulties: an umbrella review. Mental Health Review Journal 2022;27(3):241 View
  51. Jurin T, Šoštarić M, Jokić-Begić N, Lauri Korajlija A. mSexHealth: An Overview of Mobile Sexual Health Applications. Journal of Sex & Marital Therapy 2023;49(2):129 View
  52. Denecke K, Vaaheesan S, Arulnathan A. A Mental Health Chatbot for Regulating Emotions (SERMO) - Concept and Usability Test. IEEE Transactions on Emerging Topics in Computing 2021;9(3):1170 View
  53. Hwang B, Granger D, Brecht M, Doering L. Cognitive behavioral therapy versus general health education for family caregivers of individuals with heart failure: a pilot randomized controlled trial. BMC Geriatrics 2022;22(1) View
  54. Diano F, Sica L, Ponticorvo M. A Systematic Review of Mobile Apps as an Adjunct to Psychological Interventions for Emotion Dysregulation. International Journal of Environmental Research and Public Health 2023;20(2):1431 View
  55. Lam C, Milne-Ives M, Harrington R, Jani A, Helena van Velthoven M, Harding T, Meinert E, Mulvaney S. Internet of things–Enabled technologies as an intervention for childhood obesity: A systematic review. PLOS Digital Health 2022;1(4):e0000024 View
  56. Tan Y, Lattie E, Qiu Y, Teng Z, Wu C, Tang H, Chen J. Accessibility of mental health support in China and preferences on web-based services for mood disorders: A qualitative study. Internet Interventions 2021;26:100475 View
  57. Wiegel J, Seppen B, van der Leeden M, van der Esch M, de Vries R, Bos W. Adherence to Telemonitoring by Electronic Patient-Reported Outcome Measures in Patients with Chronic Diseases: A Systematic Review. International Journal of Environmental Research and Public Health 2021;18(19):10161 View
  58. Gonçalves J, Braghetta C, Alvarenga W, Gorenstein C, Lucchetti G, Vallada H. Development of a comprehensive flourishing intervention to promote mental health using an e-Delphi technique. Frontiers in Psychiatry 2023;14 View
  59. Sharma M, De Maio M, Young K, Santopietro J. Transformation of Outpatient Psychiatry. Psychiatric Clinics of North America 2022;45(1):57 View
  60. Tonn P, Seule L, Degani Y, Herzinger S, Klein A, Schulze N. Digital Content-Free Speech Analysis Tool to Measure Affective Distress in Mental Health: Evaluation Study. JMIR Formative Research 2022;6(8):e37061 View
  61. Erhardt D, Bunyi J, Dodge-Rice Z, Neary M, Schueller S. Digitized thought records: a practitioner-focused review of cognitive restructuring apps. The Cognitive Behaviour Therapist 2022;15 View
  62. Hesse B, Kwasnicka D, Ahern D. Emerging digital technologies in cancer treatment, prevention, and control. Translational Behavioral Medicine 2021;11(11):2009 View
  63. Militello L, Hutson E. The Good, the Bad, and the Potential. Advances in Family Practice Nursing 2022;4(1):173 View
  64. Wiegel J, Seppen B, Nurmohamed M, Bos W, ter Wee M. Who stop telemonitoring disease activity and who adhere: a prospective cohort study of patients with inflammatory arthritis. BMC Rheumatology 2022;6(1) View
  65. Strongylou D, Flowers P, McKenna R, Kincaid R, Clutterbuck D, Hammoud M, Heng J, Kerr Y, McDaid L, Frankis J. Understanding and responding to remote mental health help-seeking by gay, bisexual and other men who have sex with men (GBMSM) in the U.K. and Republic of Ireland: a mixed-method study conducted in the context of COVID-19. Health Psychology and Behavioral Medicine 2022;10(1):357 View
  66. Baek S, Lee S, Lee Y, Chung S, Choi C, Lee H, Jo M, Yun S, Lee J. Effects of Mobile Healthcare Applications on the Lifestyle of Patients With Breast Cancer: A Protocol for a Randomized Clinical Trial. Journal of Breast Cancer 2022;25(5):425 View
  67. Knouse L, Hu X, Sachs G, Isaacs S, König L. Usability and feasibility of a cognitive-behavioral mobile app for ADHD in adults. PLOS Digital Health 2022;1(8):e0000083 View
  68. Saad A, Magwood O, Aubry T, Alkhateeb Q, Hashmi S, Hakim J, Ford L, Kassam A, Tugwell P, Pottie K, Demidenko E. Mobile interventions targeting common mental disorders among pregnant and postpartum women: An equity-focused systematic review. PLOS ONE 2021;16(10):e0259474 View
  69. Smith S, Somers T, Kuhn E, Laber E, Sung A, Syrjala K, Feger B, Kelleher S, Majestic C, Gebert R, LeBlanc M, Owen J, Applebaum A. A SMART approach to optimizing delivery of an mHealth intervention among cancer survivors with posttraumatic stress symptoms. Contemporary Clinical Trials 2021;110:106569 View
  70. Tsai Z, Kiss A, Nadeem S, Sidhom K, Owais S, Faltyn M, Lieshout R. Evaluating the effectiveness and quality of mobile applications for perinatal depression and anxiety: A systematic review and meta-analysis. Journal of Affective Disorders 2022;296:443 View
  71. Lattie E, Stiles-Shields C, Graham A. An overview of and recommendations for more accessible digital mental health services. Nature Reviews Psychology 2022;1(2):87 View
  72. Eisner E, Berry N, Morris R, Emsley R, Haddock G, Machin M, Hassan L, Bucci S. Exploring engagement with the CBT-informed Actissist smartphone application for early psychosis. Journal of Mental Health 2023;32(3):643 View
  73. Shubina I. Supporting Youth with PTSD Through Technology Usage as a Tool in Psychological Intervention Considering School Environments: A Bibliometric Analysis. SSRN Electronic Journal 2022 View
  74. Diano F, Sica L, Ponticorvo M. Empower Psychotherapy with mHealth Apps: The Design of “Safer”, an Emotion Regulation Application. Information 2023;14(6):308 View
  75. Seiferth C, Färber T, Pape M, Schoemann N, Dieberger A, Schroeder S, Herpertz S, Wolstein J, Steins-Loeber S. Differential effects of the individualized gender-sensitive mHealth intervention I-GENDO on eating styles in individuals with overweight and obesity – a randomized controlled trial. BMC Digital Health 2023;1(1) View
  76. Kim H, Lee K, Lee Y, Park Y, Park Y, Yu Y, Park J, Noh S. The Effectiveness of a Mobile Phone–Based Physical Activity Program for Treating Depression, Stress, Psychological Well-Being, and Quality of Life Among Adults: Quantitative Study. JMIR mHealth and uHealth 2023;11:e46286 View
  77. Morello K, Schäfer S, Kunzler A, Priesterroth L, Tüscher O, Kubiak T. Cognitive reappraisal in mHealth interventions to foster mental health in adults: a systematic review and meta-analysis. Frontiers in Digital Health 2023;5 View
  78. Chiwanga F, Woodford J, Masika G, Richards D, Savi V, von Essen L. An mHealth Intervention to Improve Guardians’ Adherence to Children’s Follow-Up Care for Acute Lymphoblastic Leukemia in Tanzania (GuardiansCan Project): Protocol for a Development and Feasibility Study. JMIR Research Protocols 2023;12:e48799 View
  79. Wang J, Wu Z, Choi S, Sen S, Yan X, Miner J, Sander A, Lyden A, Troost J, Carlozzi N. The Dosing of Mobile-Based Just-in-Time Adaptive Self-Management Prompts for Caregivers: Preliminary Findings From a Pilot Microrandomized Study. JMIR Formative Research 2023;7:e43099 View
  80. Rosansky J, Okst K, Tepper M, Baumgart Schreck A, Fulwiler C, Wang P, Schuman-Olivier Z. Participants’ Engagement With and Results From a Web-Based Integrative Population Mental Wellness Program (CHAMindWell) During the COVID-19 Pandemic: Program Evaluation Study. JMIR Mental Health 2023;10:e48112 View
  81. Mottaghi S, Rahimian Boogar I, Moradi S, Sotodehasl N. The Effectiveness of Online Cognitive-Behavioral Stress Management Training on Blood Glucose Control and Problems in Sexual Function of Married Women with Diabetes During the Coronavirus Pandemic: A Quasi-Experimental Study. Journal of Rafsanjan University of Medical Sciences 2023;22(4):333 View
  82. Eltahawy L, Essig T, Myszkowski N, Trub L. Can robots do therapy?: Examining the efficacy of a CBT bot in comparison with other behavioral intervention technologies in alleviating mental health symptoms. Computers in Human Behavior: Artificial Humans 2024;2(1):100035 View
  83. Bjornstad G, Sonthalia S, Rouse B, Freeman L, Hessami N, Dunne J, Axford N. A comparison of the effectiveness of cognitive behavioural interventions based on delivery features for elevated symptoms of depression in adolescents: A systematic review. Campbell Systematic Reviews 2024;20(1) View
  84. Erickson B, Griffith J, Wensheng G, Mengying Y, Herman T, Bradley C, Quentin Clemens J, Farrar J, Gupta P, Kreder K, Henry Lai H, Naliboff B, Newman D, Rodriguez L, Spitznagle T, Sutcliffe S, Sutherland S, Taple B, Richard Landis J. Ecological momentary assessment of pelvic pain and urinary urgency variability in urologic chronic pelvic pain syndrome and their association with illness impact and quality of life: Findings from the multidisciplinary approach to the study of chronic pelvic pain symptom patterns study. Neurourology and Urodynamics 2024;43(4):893 View
  85. Fuhr D, Wolf-Ostermann K, Hoel V, Zeeb H. Digitale Technologien zur Verbesserung der psychischen Gesundheit. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 2024;67(3):332 View

Books/Policy Documents

  1. Prescott J, Iliff P, Edmondson D, Cross D. Mobile Technologies in Educational Organizations. View
  2. Markowitsch H, Schreier M. Reframing der Bedürfnisse. View
  3. Martínez-Borba V, Suso-Ribera C, Osma J. Pervasive Computing Paradigms for Mental Health. View
  4. Rathbone A, Cross D, Prescott J. Digital Innovations for Mental Health Support. View
  5. Gál É. Smartphone Apps for Health and Wellness. View
  6. Pedrelli P, Bentley K, Pittman M, Meyer A, Fisher L. The Massachusetts General Hospital Handbook of Cognitive Behavioral Therapy. View
  7. Goodings L, Ellis D, Tucker I. Understanding Mental Health Apps. View