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Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial

Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial

Proprioception is a neural process that includes the body’s ability to respond to sensory inputs from the environment [11]. Proprioceptive exercise training can enhance the sensorimotor system’s ability to adapt to changing environments, thereby protecting the body from injuries [12].

Tugce Poyraz Isleyen, Ela Tarakci, Gokce Leblebici, Ipek Yeldan, Bulent Zulfikar

JMIR Res Protoc 2025;14:e66770

Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies

Exploring Nonresponse to Botulinum Toxin in Aesthetics: Narrative Review of Key Trigger Factors and Effective Management Strategies

This immune response can be influenced by epigenetic changes affecting the expression of genes involved in immune function, including those encoding for proteins interacting with Bo NT [9,16]. The overall reactivity of an individual patient’s immune system–specifically, the ability of an antigen to stimulate an immune response–can be influenced by exogenous factors, such as environmental allergens.

George Kroumpouzos, Fernando Silikovich

JMIR Dermatol 2025;8:e69960

Usability and User Experience Testing of a Co-Designed Electronic Patient-Reported Outcomes App (“MyPal for Adults”) for Palliative Cancer Care: Mixed Methods Study

Usability and User Experience Testing of a Co-Designed Electronic Patient-Reported Outcomes App (“MyPal for Adults”) for Palliative Cancer Care: Mixed Methods Study

The problems coded as the context of use included the following: (1) the participant tried to use the My Pal patient-tailored disease-related information search engine to “ask a question” (expecting a chat function) to the clinicians and (2) the size of some UI elements, that is, the module buttons, text displayed.

Panos Bonotis, Pantelis Angelidis, Pantelis Natsiavas

JMIR Hum Factors 2025;12:e57342

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Motor skill acquisition is the within-session improvement in a motor skill as a function of practice [14]. Previous in-lab studies have associated motor skill deficits with APOE carrier status, hippocampal atrophy, functional decline, and amyloid deposition among people diagnosed with amnestic MCI [15-18].

Andrew Hooyman, Matt J Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y Schaefer

JMIR Aging 2025;8:e67298

Blended Mobile-Based Interventions With Integrated Virtual Reality Exposure Therapy for Anxiety Disorders: Thematic Analysis of Patient Perspectives

Blended Mobile-Based Interventions With Integrated Virtual Reality Exposure Therapy for Anxiety Disorders: Thematic Analysis of Patient Perspectives

To further facilitate usability, a function to consume the content while being absent from the screen was desired: Not being able to lock the screen, not being able to close the app. These are mechanisms that in some way make sense, but most of the time I used the app while cleaning, doing my laundry, or doing my homework. And then your cellphone is in another room and you have to click to proceed. That wasn’t severe, but also not comfortable.

Jari Planert, Anne-Sophie Hildebrand, Alla Machulska, Kati Roesmann, Marie Neubert, Sebastian Pilgramm, Juliane Pilgramm, Tim Klucken

JMIR Hum Factors 2025;12:e60957

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial

We will explore potential biases in missing questionnaires and EMA data (eg, as a function of baseline characteristics). This will be accomplished using chi-square tests for categorical variables and t tests or nonparametric Wilcoxon rank-sum tests for continuous variables.

Ashley D Kendall, Emily Pela, Danielle Amonica, Erin Jaworski, Brenikki Floyd, The AIM+ Community Advisory Board

JMIR Res Protoc 2025;14:e71867

Guideline-Incorporated Large Language Model-Driven Evaluation of Medical Records Using MedCheckLLM

Guideline-Incorporated Large Language Model-Driven Evaluation of Medical Records Using MedCheckLLM

It holds the potential to function as a quality assurance framework throughout patient care due to its advantages of separate partitioning of the LLM and the guidelines, rather than training guidelines into an LLM. The flexibility of this approach allows for immediate implementation of guideline updates or the option to implement customized protocols for subgroups of patients.

Marc Cicero Schubert, Stella Soyka, Wolfgang Wick, Varun Venkataramani

JMIR Form Res 2025;9:e53335

Mobile Health App for Adolescent Asthma Self-Management: Development and Usability Study of the Pulmonary Education and Knowledge Mobile Asthma Action Plan

Mobile Health App for Adolescent Asthma Self-Management: Development and Usability Study of the Pulmonary Education and Knowledge Mobile Asthma Action Plan

Examples include the inability to access a function by clicking an icon, necessitating the use of a menu bar instead, or encountering difficulty when attempting to exit a screen. These issues require prioritization. Finally, a catastrophic severity rating indicates a critical system failure that demands immediate remediation. For instance, a user’s inability to locate or input essential information constitutes a catastrophic issue. Nielsen-Shneiderman heuristics.

Xing He, Jiang Bian, Ariel Berlinski, Yi Guo, A Larry Simmons, S Alexandra Marshall, Carolyn J Greene, Rita Hudson Brown, Jessica Turner, Tamara T Perry

JMIR Form Res 2025;9:e64212

Mainstream Smart Home Technology–Based Intervention to Enhance Functional Independence in Individuals With Complex Physical Disabilities: Single-Group Pre-Post Feasibility Study

Mainstream Smart Home Technology–Based Intervention to Enhance Functional Independence in Individuals With Complex Physical Disabilities: Single-Group Pre-Post Feasibility Study

In addition, the OT conducted functional assessments relevant to the identified tasks in areas such as upper extremity motor function, cognitive function, visual function, auditory function, tactile function, speech and language function, and activity tolerance.

Dan Ding, Lindsey Morris, Gina Novario, Andrea Fairman, Kacey Roehrich, Palma Foschi Walko, Jessica Boateng

JMIR Rehabil Assist Technol 2025;12:e70855