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Comparison of Electronic Surveillance With Routine Monitoring for Patients With Lymphoma at High Risk of Relapse: Prospective Randomized Controlled Phase 3 Trial (Sentinel Lymphoma)

Comparison of Electronic Surveillance With Routine Monitoring for Patients With Lymphoma at High Risk of Relapse: Prospective Randomized Controlled Phase 3 Trial (Sentinel Lymphoma)

Relapse or progression is a major event in the management of lymphoma. Predictive factors for relapse include histological subtype, extranodal involvement, high metabolic volume, and elevated serum lactate dehydrogenase (LDH) levels [1]. Early detection of relapse correlates with survival. In most cases, relapse is detected by the appearance of symptoms, clinical signs, or biological abnormalities [2-4].

Katell Le Dû, Adrien Chauchet, Sophie Sadot-Lebouvier, Olivier Fitoussi, Bijou Fontanet, Arnaud Saint-Lezer, Frédéric Maloisel, Cédric Rossi, Sylvain Carras, Anne Parcelier, Magali Balavoine, Anne-Lise Septans

JMIR Cancer 2025;11:e65960

High-Frequency Cognitive Control Training for Depression: Case Report

High-Frequency Cognitive Control Training for Depression: Case Report

Systematic reviews and meta-analyses of CCT have reported significant small to medium effects on depressive symptomatology [5-7], and some clinical studies have found beneficial long-term effects of CCT for depression or relapse prevention of depression [3,8]. However, the working mechanisms of CCT are currently unclear (for a review, see von Bastian et al [9]).

Yannick Vander Zwalmen, Kristof Hoorelbeke, David Demeester, Ernst H W Koster

JMIR Form Res 2024;8:e56598

Presenting and Evaluating a Smartwatch-Based Intervention for Smoking Relapse (StopWatch): Feasibility and Acceptability Study

Presenting and Evaluating a Smartwatch-Based Intervention for Smoking Relapse (StopWatch): Feasibility and Acceptability Study

Despite the support offered, as many as 75% of smokers who are abstinent for 4 weeks after their quit date will relapse to smoking within 1 year [6]. Therefore, the provision of additional support when the smoker lapses would clearly be beneficial as an adjunct to these more conventional therapies, as a means of improving adherence and ultimately the success of the quit attempt.

Chris Stone, Rosie Essery, Joe Matthews, Felix Naughton, Marcus Munafo, Angela Attwood, Andy Skinner

JMIR Form Res 2024;8:e56999

Efficacy and Safety of the Natural Killer T Cell–Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial

Efficacy and Safety of the Natural Killer T Cell–Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial

Inclusion criteria Patients who provided written consent for trial participation Patients had been diagnosed with relapsed multiple sclerosis (MS), including relapse-remitting MS and/or secondary progressive MS, based on the revised Mc Donald criteria or were diagnosed with MS by an attending physician as noted in their medical records Patients with at least two medically confirmed clinical exacerbations within 24 months prior to consent or one exacerbation within 12 months prior to consent Patients with at least

Tomoko Okamoto, Takami Ishizuka, Reiko Shimizu, Yasuko Asahina, Harumasa Nakamura, Yuko Shimizu, Yoichiro Nishida, Takanori Yokota, Youwei Lin, Wakiro Sato, Takashi Yamamura

JMIR Res Protoc 2024;13:e46709

Monitoring Cigarette Smoking and Relapse in Young Adults With and Without Remote Biochemical Verification: Randomized Brief Cessation Study

Monitoring Cigarette Smoking and Relapse in Young Adults With and Without Remote Biochemical Verification: Randomized Brief Cessation Study

The relapse monitoring period began on day 9 and lasted through the end of the study (day 35). Participants in the r CO group completed weekly study visits over the phone and returned for a final in-person visit at day 35, whereas participants in the w CO group attended weekly in-person visits to submit breath CO samples.

Erin A McClure, Nathaniel Baker, Kyle J Walters, Rachel L Tomko, Matthew J Carpenter, Elizabeth Bradley, Lindsay M Squeglia, Kevin M Gray

JMIR Form Res 2023;7:e47662

Preliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial

Preliminary Effectiveness of a Remotely Monitored Blood Alcohol Concentration Device as Treatment Modality: Protocol for a Randomized Controlled Trial

Alcohol use disorder (AUD) is a chronic disorder that presents with a predisposition to relapse and is among the top 5 leading causes of disability-adjusted life years [1]. Worldwide, 5.9% of deaths (7.6% in men, 4.0% in women) are due to alcohol [2], and within the United States, medical costs for AUD are reported to be over $120 billion per year [3]. In addition, AUD has a high occurrence of other comorbid psychiatric conditions (eg, depression and generalized anxiety) [4,5].

Frank D Buono, Colette Gleed, Martin Boldin, Allison Aviles, Natalie Wheeler

JMIR Res Protoc 2022;11(1):e30186

Clinical Utility of Wearable Sensors and Patient-Reported Surveys in Patients With Schizophrenia: Noninterventional, Observational Study

Clinical Utility of Wearable Sensors and Patient-Reported Surveys in Patients With Schizophrenia: Noninterventional, Observational Study

Psychotic symptom exacerbation and relapse are frequently observed in patients with schizophrenia and can lead to a decline in social functioning, reduced treatment response, and worsening of clinical outcomes [1]. These patients and their caregivers experience an increased burden because of relapse and consequent hospitalization [2-4].

Adrienne C Lahti, Dai Wang, Huiling Pei, Susan Baker, Vaibhav A Narayan

JMIR Ment Health 2021;8(8):e26234

A Smartphone-Delivered Ecological Momentary Intervention for Problem Gambling (GamblingLess: Curb Your Urge): Single-Arm Acceptability and Feasibility Trial

A Smartphone-Delivered Ecological Momentary Intervention for Problem Gambling (GamblingLess: Curb Your Urge): Single-Arm Acceptability and Feasibility Trial

As such, apps can serve as a “conduit for intervention any time and in almost any location” [18], which is considered important for preventing gambling behavior and relapse [19,20]. There is growing evidence for the acceptability, feasibility, and preliminary effectiveness of smartphone-delivered interventions for numerous chronic medical conditions [21-23] and mental health concerns [24,25].

Chloe O Hawker, Stephanie S Merkouris, George J Youssef, Nicki A Dowling

J Med Internet Res 2021;23(3):e25786

Innovation in Pain Rehabilitation Using Co-Design Methods During the Development of a Relapse Prevention Intervention: Case Study

Innovation in Pain Rehabilitation Using Co-Design Methods During the Development of a Relapse Prevention Intervention: Case Study

In the present project, called the SOLACE project (grant number: SIA RAAK 2014-01-23), we developed a relapse prevention intervention for patients with chronic musculoskeletal pain who participate in an interdisciplinary, multimodal pain treatment program. The primary reason for adopting a co-design approach was that, despite high prevalence rates of relapse after successful treatment, there is a paucity of available research to explain relapse for this particular population [25,26].

Stefan Elbers, Christa van Gessel, Reint Jan Renes, Remko van der Lugt, Harriët Wittink, Sander Hermsen

J Med Internet Res 2021;23(1):e18462