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Effects of Cold and Vibration on Venipuncture Pain Management in Children Aged 2-7 Years Old: Randomized Controlled Trial

Effects of Cold and Vibration on Venipuncture Pain Management in Children Aged 2-7 Years Old: Randomized Controlled Trial

A randomized controlled trial was conducted to select children aged 2-7 years requiring venipuncture between May 2023 and November 2023 in the Department of Pediatrics of a tertiary hospital in Changsha City, Hunan Province, including the pediatric emergency department and pediatric ward, and the main reason for venipuncture was blood sampling, requiring peripheral intravenous access. This trial was reported using CONSORT (Consolidated Standards of Reporting Trials) guidelines.

Zi-yun Zhou, Long-yi Hu, Ming-li Wang, Si-qi Li, Le-shan Zhou

JMIR Pediatr Parent 2025;8:e67918


Promoting Dairy Consumption Among Families: Development and User Experience Study of a Web-Based Nutrition Intervention

Promoting Dairy Consumption Among Families: Development and User Experience Study of a Web-Based Nutrition Intervention

This study was single-blind, meaning that participants were unaware of whether they had been randomized to the intervention or control group. Recruitment materials described the study’s objective as evaluating a family-based nutrition intervention, without specific reference to dairy products. Interested families could contact the research team via email or phone for further information and to complete an eligibility screening.

Juliette Lemay, Jacynthe Roberge, Véronique Provencher, Angelo Tremblay, Shirin Panahi, Raphaëlle Jacob, Lucie Brunelle, Gabrielle Saintonge, Vicky Drapeau

JMIR Form Res 2025;9:e66582


Effect of Minimal Individual or Group Enhancement in an eHealth Program on Mental Health, Health Behavior, and Work Ability in Employees With Obesity: Randomized Controlled Trial

Effect of Minimal Individual or Group Enhancement in an eHealth Program on Mental Health, Health Behavior, and Work Ability in Employees With Obesity: Randomized Controlled Trial

This study was a randomized controlled trial (RCT) aiming to improve participants’ health behavior and thus, weight loss [31]. Participants were assigned to one of the 3 treatment arms: e Health, e Health+Group, or e Health+Individual. Each treatment arm used an e Health program, Healthy Weight Coaching (HWC), extensively detailed by Suojanen et al [32]. In addition, the hybrid treatment arms received 3 remotely facilitated group or individual sessions.

Siniriikka A Männistö, Joona Muotka, Laura-Unnukka Suojanen, Raimo Lappalainen, Kirsi H Pietiläinen, Riitta Korpela

JMIR Ment Health 2025;12:e66518


An Online Family Literacy and Wellness Program for Latino Dual Language Learners: Pilot Randomized Waitlist Controlled Trial

An Online Family Literacy and Wellness Program for Latino Dual Language Learners: Pilot Randomized Waitlist Controlled Trial

Using community-engaged research strategies, we partnered with parents to refine the program and subsequently conducted a pilot randomized controlled trial (RCT). Consistent with the approach proposed by Baumann and Cabassa [19], we intentionally focused on intervention reach, design, and equity-relevant implementation outcomes. These insights can inform similar cross-sector education-health care partnerships that aim to promote equity for Latino DLLs and their families.

Kevin D Guerrero, Lucia Lakata, Daniel Lima, Caroline Mendoza, Nila Uthirasamy, Lesley M Morrow, Silvia Perez-Cortes, Maria Pellerano, Alicja Bator, Pamela Ohman Strickland, Benjamin F Crabtree, Manuel E Jimenez

JMIR Pediatr Parent 2025;8:e60764


Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

We conducted a 2-week exploratory double-blind randomized controlled trial comparing a Woebot for mood and anxiety with generative elements (Gen-W-MA, 81/160, 50.6%) against a rules-based version of this same product, that is, Woebot for mood and anxiety (W-MA, 79/160, 49.3%). W-MA is an investigational DMHI that delivers a guided self-help program using cognitive behavioral therapy, psychoeducation, and self-management tools through brief conversations with a relational agent named Woebot (Woebot Health).

Timothy R Campellone, Megan Flom, Robert M Montgomery, Lauren Bullard, Maddison C Pirner, Aaron Pavez, Michelle Morales, Devin Harper, Catherine Oddy, Tom O'Connor, Jade Daniels, Stephanie Eaneff, Valerie L Forman-Hoffman, Casey Sackett, Alison Darcy

J Med Internet Res 2025;27:e67365


Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

Consumer-Grade Neurofeedback With Mindfulness Meditation: Meta-Analysis

For the present study, 2 types of randomized studies were included. We leveraged randomized controlled trials (RCTs) with between-participant controls as well as within-participant controls (ie, participants perform mb NF and meditation only, with the order randomized). The following open questions were addressed using quantitative synthesis: (1) Is there evidence that participants are learning to regulate brain signals using neurofeedback, and reporting higher mindfulness?

Isaac Treves, Zia Bajwa, Keara D Greene, Paul A Bloom, Nayoung Kim, Emma Wool, Simon B Goldberg, Susan Whitfield-Gabrieli, Randy P Auerbach

J Med Internet Res 2025;27:e68204


Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study

Doi et al [47] conducted a randomized controlled trial involving 142 patients with knee osteoarthritis. They found that a home-based quadriceps strengthening program involving 20 repetitions of a slow knee extension movement implemented 4 times daily for 8 weeks was as effective as nonsteroidal anti-inflammatory drugs for improved pain, stiffness, physical function, and Qo L outcomes.

Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

J Med Internet Res 2025;27:e58393


Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

We thus performed an exploratory, prospective, open-label, parallel, single-center, randomized controlled trial (RCT) to investigate the effectiveness of CGM on short-term, in-hospital mortality among frail and critically ill patients with COVID-19. This is an exploratory, prospective, open-label, parallel, single-center RCT.

Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

J Med Internet Res 2025;27:e67012


Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial

In this study, we aimed to test whether the inclusion of tailored prompts aimed at achieving usage goals can increase the efficacy of an ICBT stress recovery intervention for health care workers in a randomized controlled trial (RCT). The “For Recovery from Stress” (FOREST) is a 6-week ICBT intervention [14], incorporating mindfulness and focused on stress recovery [15]. FOREST+ is the updated version of FOREST, designed to meet the needs of health care workers [5].

Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

JMIR Ment Health 2025;12:e62782


Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

Effect of a Web-Based Heartfulness Program on the Mental Well-Being, Biomarkers, and Gene Expression Profile of Health Care Students: Randomized Controlled Trial

This was a prospective randomized control trial assessing changes in the PSS and DASS-21 scores over a 12-week period. Both are validated questionnaires studied extensively in the literature [26,27]. The PSS consists of 10 items that measure the subjective feelings of the amount of stress in the participants by assessing thoughts and feelings in the previous month. Each question is scored from 0 (never) to 4 (very often) with a total possible score range of 0 to 40.

Jayaram Thimmapuram, Kamlesh D Patel, Deepti Bhatt, Ajay Chauhan, Divya Madhusudhan, Kashyap K Bhatt, Snehal Deshpande, Urvi Budhbhatti, Chaitanya Joshi

JMIR Bioinform Biotech 2024;5:e65506