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Exploring Neural Idiosyncrasies in Response to Autonomous Sensory Meridian Response Videos: Naturalistic Functional Magnetic Resonance Imaging Study of Stress and Sensory Processing

Exploring Neural Idiosyncrasies in Response to Autonomous Sensory Meridian Response Videos: Naturalistic Functional Magnetic Resonance Imaging Study of Stress and Sensory Processing

Functional magnetic resonance imaging (f MRI) data were obtained through the gradient-echo echo-planar imaging sequence (volumes=1728, slices=72, isotropic voxels=2.0 mm, repetition time=1000 ms, echo time=39.80 ms, field of view=224×224 mm). The MPRAGE sequence lasted approximately 7 minutes and 20 seconds, and the echo-planar imaging sequence lasted approximately 29 minutes.

Hye Eun Lee, Sungbin Youk, Yoon Esther Lee, Musa Malik, René Weber

J Med Internet Res 2025;27:e68586

Cognitive and Spontaneous Brain Activity in Nonaddictive Smartphone Users Among Older Adults in China: Cross-Sectional Study

Cognitive and Spontaneous Brain Activity in Nonaddictive Smartphone Users Among Older Adults in China: Cross-Sectional Study

The flowchart of the whole study. f MRI: functional magnetic resonance imaging; GAD-7: Generalized Anxiety Disorder; ISI: Insomnia Severity Index; Mo CA-B: Montreal Cognitive Assessment-Basic; MRI: magnetic resonance imaging; PHQ-9: Patient Health Questionnaire; PSU: problematic smartphone use; SAS-SV: Smartphone Addiction Scale-Short Version. For the appropriate sample size for the survey, we used G*Power (version 3.1; UC Regents), a widely recognized software tool for conducting power analyses.

Zhenyu Wan, Xucong Qin, Qirong Wan, Baohua Xu, Hong Lin, Fangcheng Ouyang, Gaohua Wang

J Med Internet Res 2025;27:e63485

Functional Magnetic Resonance Imaging Analysis of the Clinical Effect and Cerebral Mechanism of Tuina in Lumbar Disc Herniation: Protocol for a Randomized Controlled Parallel Group Trial

Functional Magnetic Resonance Imaging Analysis of the Clinical Effect and Cerebral Mechanism of Tuina in Lumbar Disc Herniation: Protocol for a Randomized Controlled Parallel Group Trial

Functional magnetic resonance imaging (f MRI) is an imaging technique that depicts the neural activity in the brain in real time based on the changes in local oxygen consumption and cerebral blood flow [8]. f MRI is widely used in pain-related research, and it can detect the effects of different types of pain on brain activity. A number of studies have shown that structural and functional changes can occur in the brains of patients with LDH [9].

Changzheng Jiang, Hongye Huang, Lechun Chen, Jingjing Jiang, Huanzhen Zhang, Jincheng Chen, Shuijin Chen, Zhigang Lin

JMIR Res Protoc 2024;13:e63852

Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial

Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial

This will consist of an anatomical T1-weighted MP-RAGE (magnetization-prepared rapid gradient-echo) scan (echo time = 3 ms, repetition time = 2500 ms, flip angle = 7o) and 7 f MRI scans for each participant: 1 f MRI scan collected during dual-echo p CASL (pseudocontinuous arterial spin labeling) (TE1/TE2 = 10/25 ms, TR = 4000 ms, 1 f MRI scan collected during CVR (TE = 21 ms, TR = 1000 ms, voxel size = 3mm x 3mm x 3mm, flip angle = 50o, number of volumes = 420), 3 runs of a language based task (TE = 25 ms, TR =

Medina Oneyi Bello, Kevin Michael Mammino, Mark Anthony Vernon, Daniel G Wakeman, Chanse Aerius Denmon, Lisa Crystal Krishnamurthy, Venkatagiri Krishnamurthy, Keith Matthew McGregor, Thomas Samuel Novak, Joe Robert Nocera

JMIR Res Protoc 2024;13:e58316

Effects of the Prolong Life With Nine Turn-Method Qigong on Fatigue, Insomnia, Anxiety, and Gastrointestinal Disorders in Patients With Chronic Fatigue Syndrome: Protocol for a Randomized Controlled Trial

Effects of the Prolong Life With Nine Turn-Method Qigong on Fatigue, Insomnia, Anxiety, and Gastrointestinal Disorders in Patients With Chronic Fatigue Syndrome: Protocol for a Randomized Controlled Trial

Therefore, we plan to use functional magnetic resonance imaging (f MRI) to analyze brain activity and connectivity data and collect stool samples to analyze the composition of the intestinal microbiota in patients with CFS. This randomized controlled trial will be conducted based on the hypothesis that the application of PLWNT could alleviate fatigue, insomnia, anxiety, and gastrointestinal symptoms in patients with CFS.

Fangfang Xie, Yanli You, Yuanjia Gu, Jiatuo Xu, Fei Yao

JMIR Res Protoc 2024;13:e53347

Reward Learning as a Potential Mechanism for Improvement in Schizophrenia Spectrum Disorders Following Cognitive Remediation: Protocol for a Clinical, Nonrandomized, Pre-Post Pilot Study

Reward Learning as a Potential Mechanism for Improvement in Schizophrenia Spectrum Disorders Following Cognitive Remediation: Protocol for a Clinical, Nonrandomized, Pre-Post Pilot Study

BACS: Brief Assessment of Cognition in Schizophrenia; BIS/BAS: Behavioral Inhibition System and Behavioral Activation System; BPRS: Brief Psychiatric Rating Scale; CAINS: Clinical Assessment Interview for Negative Symptoms; CDSS: Calgary Depression Scale for Schizophrenia; CRT: cognitive remediation therapy; f MRI: functional magnetic resonance imaging; LSP-16: Life Skills Profile; SCo RS: Schizophrenia Cognition Rating Scale; TOPF: Test of Premorbid Functioning.

Frances Dark, Graham Galloway, Marcus Gray, Matteo Cella, Veronica De Monte, Victoria Gore-Jones, Gabrielle Ritchie

JMIR Res Protoc 2024;13:e52505

Effect of Technology and Digital Media Use on Adolescent Health and Development: Protocol for a Multimethod Longitudinal Study

Effect of Technology and Digital Media Use on Adolescent Health and Development: Protocol for a Multimethod Longitudinal Study

This study will also examine the persuasive elements of self-generated and other-generated content via functional magnetic resonance imaging (f MRI; aim 3). This project will include technology importance and parent involvement as moderators. Study 2 will use f MRI to understand how neural correlates associated with positive and negative TDM experiences relate to mental and behavioral health.

Christopher N Cascio, Ellen Selkie, Megan A Moreno

JMIR Res Protoc 2023;12:e50984

Impact of App-Delivered Mindfulness Meditation on Functional Connectivity, Mental Health, and Sleep Disturbances Among Physician Assistant Students: Randomized, Wait-list Controlled Pilot Study

Impact of App-Delivered Mindfulness Meditation on Functional Connectivity, Mental Health, and Sleep Disturbances Among Physician Assistant Students: Randomized, Wait-list Controlled Pilot Study

Before randomization and again after completion of the 8-week program, all participants completed self-report assessments and functional magnetic resonance imaging (f MRI), both described in detail below. A total of 2 participants were removed from the analysis for excessive movement during f MRI, resulting in a cohort of 50% (7/14) practitioners (6/7, 86% women) and 50% (7/14) controls (5/7, 71% women; Table 1). Participants were compensated US $100 for completing both assessments.

Jeremy L Smith, Jason W Allen, Carla I Haack, Kathryn L Wehrmeyer, Kayley G Alden, Maha B Lund, Jennifer S Mascaro

JMIR Form Res 2021;5(10):e24208

Effect of Cognitive Training in Fully Immersive Virtual Reality on Visuospatial Function and Frontal-Occipital Functional Connectivity in Predementia: Randomized Controlled Trial

Effect of Cognitive Training in Fully Immersive Virtual Reality on Visuospatial Function and Frontal-Occipital Functional Connectivity in Predementia: Randomized Controlled Trial

In patients with MCI, significant associations have been observed between verbal memory improvement and left hippocampal activation in task-related f MRI after 8-week training to improve auditory processing speed and accuracy [11].

Jae Myeong Kang, Nambeom Kim, Sook Young Lee, Soo Kyun Woo, Geumjin Park, Byeong Kil Yeon, Jung Woon Park, Jung-Hae Youn, Seung-Ho Ryu, Jun-Young Lee, Seong-Jin Cho

J Med Internet Res 2021;23(5):e24526

Virtual Reality–Based Psychotherapy in Social Anxiety Disorder: fMRI Study Using a Self-Referential Task

Virtual Reality–Based Psychotherapy in Social Anxiety Disorder: fMRI Study Using a Self-Referential Task

All participants underwent f MRI while performing a self-referential processing task and completing self-report questionnaires, including the Korean version of the Social Phobia Scale (SPS) (H. Kim, unpublished) and Post-Event Rumination Scale (PERS) [28]. The participants with social anxiety disorder underwent f MRI and assessments before and after treatment, while the control participants underwent f MRI only once.

Ji-Won Hur, Hyemin Shin, Dooyoung Jung, Heon-Jeong Lee, Sungkil Lee, Gerard J Kim, Chung-Yean Cho, Seungmoon Choi, Seung-Moo Lee, Chul-Hyun Cho

JMIR Ment Health 2021;8(4):e25731