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Analysis of Metabolic and Quality-of-Life Factors in Patients With Cancer for a New Approach to Classifying Walking Habits: Secondary Analysis of a Randomized Controlled Trial

Analysis of Metabolic and Quality-of-Life Factors in Patients With Cancer for a New Approach to Classifying Walking Habits: Secondary Analysis of a Randomized Controlled Trial

By 2040, it is projected that there will be 28.4 million new cases of cancer worldwide, indicating a 47% increase compared with the 19.3 million cases reported in 2020 [1]. Consequently, enhancing the quality of life (QOL) for patients with cancer has become imperative owing to the rising number of patients with cancer and their extended life expectancy.

Yae Won Tak, Junetae Kim, Haekwon Chung, Sae Byul Lee, In Ja Park, Sei Won Lee, Min-Woo Jo, Jong Won Lee, Seunghee Baek, Yura Lee

J Med Internet Res 2025;27:e52694

Development of a Comprehensive Decision Support Tool for Chemotherapy-Cycle Prescribing: Initial Usability Study

Development of a Comprehensive Decision Support Tool for Chemotherapy-Cycle Prescribing: Initial Usability Study

In oncology, electronic patient-reported outcome (e PRO)–based monitoring has gained a great deal of interest in recent years. e PROs have been shown to improve quality of life (Qo L) and survival and reduce the number of unscheduled visits among patients receiving chemotherapy for advanced cancer [4-6].

Sanna Iivanainen, Reetta Arokoski, Santeri Mentu, Laura Lang, Jussi Ekström, Henri Virtanen, Vesa Kataja, Jussi Pekka Koivunen

JMIR Form Res 2025;9:e62749

Breast Cancer Vlogs on YouTube: Descriptive and Content Analyses

Breast Cancer Vlogs on YouTube: Descriptive and Content Analyses

Overall, social support is a prominent theme in literature about breast cancer communication on social media [2]. You Tube is growing as a source of “peer-to-peer health information sharing and support” [3]. The importance of peer support across cancer is widely acknowledged [4]. Breast cancer peer support programs have been shown to be effective in enhancing patients’ quality of life [5], particularly regarding the alleviation of depression and anxiety [6].

Nina Morena, Elly Dimya Htite, Yitzchok Ahisar, Victoria Hayman, Carrie A Rentschler, Ari N Meguerditchian

JMIR Infodemiology 2025;5:e66812

Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial

Feasibility, Acceptability, and Potential Effects of a Digital Oral Anticancer Agent Intervention: Protocol for a Pilot Randomized Controlled Trial

It is estimated that 18.1 million new cancer diagnoses occur globally every year [1,2]. Whereas survival rates vary among cancer diagnoses and countries, mortality rates for the most prevalent cancers in high-income countries continue to decrease [2,3]. Individuals with cancer are living longer and with higher quality of life due to improvements in prevention, detection, and advancements in treatment [4].

Saima Ahmed, Christine Maheu, Walter Gotlieb, Gerald Batist, Carmen G Loiselle

JMIR Res Protoc 2025;14:e55475

Lessons Learned From European Health Data Projects With Cancer Use Cases: Implementation of Health Standards and Internet of Things Semantic Interoperability

Lessons Learned From European Health Data Projects With Cancer Use Cases: Implementation of Health Standards and Internet of Things Semantic Interoperability

Cancer is one of the main causes of death in Europe and worldwide, after cardiovascular diseases. According to the World Health Organization (WHO), cancer is the second leading cause of death and morbidity in Europe, with more than 3.7 million new cases and 1.9 million deaths each year [1].

Amelie Gyrard, Somayeh Abedian, Philip Gribbon, George Manias, Rick van Nuland, Kurt Zatloukal, Irina Emilia Nicolae, Gabriel Danciu, Septimiu Nechifor, Luis Marti-Bonmati, Pedro Mallol, Stefano Dalmiani, Serge Autexier, Mario Jendrossek, Ioannis Avramidis, Eva Garcia Alvarez, Petr Holub, Ignacio Blanquer, Anna Boden, Rada Hussein

J Med Internet Res 2025;27:e66273

Evaluating the Diagnostic Accuracy of ChatGPT-4 Omni and ChatGPT-4 Turbo in Identifying Melanoma: Comparative Study

Evaluating the Diagnostic Accuracy of ChatGPT-4 Omni and ChatGPT-4 Turbo in Identifying Melanoma: Comparative Study

Given that patients are increasingly presenting internet-derived diagnostics during cancer consultations, it is imperative to understand the capabilities of commonly used AI engines, such as Chat GPT [4]. In this study, we compare the capabilities of two models—Chat GPT-4 Omni (GPT-4o) and Chat GPT-4 Turbo (GPT-4 Turbo)—in identifying melanoma versus “not melanoma” skin lesions. These LLMs were chosen due to their accessibility and ability to answer image-based dermatology board-style questions correctly [5].

Samantha S. Sattler, Nitin Chetla, Matthew Chen, Tamer Rajai Hage, Joseph Chang, William Young Guo, Jeremy Hugh

JMIR Dermatol 2025;8:e67551

Monthly Variations in Colorectal Cancer Screening Tests Among Federally Qualified Health Center Patients in Missouri: Quality Improvement Project

Monthly Variations in Colorectal Cancer Screening Tests Among Federally Qualified Health Center Patients in Missouri: Quality Improvement Project

Colorectal cancer (CRC) is the third most common cancer in the United States and the second leading cause of cancer deaths [1]. Evidence shows that screening detects CRC at earlier stages, and its development can be prevented by removing precancerous polyps.

Jane A McElroy, Jamie B Smith, Kevin D Everett

JMIR Cancer 2025;11:e64809

Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study

Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study

Cervical cancer is the fourth most common cancer among women, with an estimated 660,000 new cases and 350,000 deaths globally in 2022 [1,2]. It is the most common cancer in 25 countries and the leading cause of cancer death in 37 countries. Despite being largely preventable through human papillomavirus (HPV) vaccination [3], the high incidence and persistence of high-risk HPV (hr HPV) remain the primary risk factors for cervical cancer [4] and related diseases [5-7].

Zhen Lu, Binhua Dong, Hongning Cai, Tian Tian, Junfeng Wang, Leiwen Fu, Bingyi Wang, Weijie Zhang, Shaomei Lin, Xunyuan Tuo, Juntao Wang, Tianjie Yang, Xinxin Huang, Zheng Zheng, Huifeng Xue, Shuxia Xu, Siyang Liu, Pengming Sun, Huachun Zou

JMIR Public Health Surveill 2025;11:e67840

Patient and Provider Perspectives of a Web-Based Intervention to Support Symptom Management After Radioactive Iodine Treatment for Differentiated Thyroid Cancer: Qualitative Study

Patient and Provider Perspectives of a Web-Based Intervention to Support Symptom Management After Radioactive Iodine Treatment for Differentiated Thyroid Cancer: Qualitative Study

Thyroid cancer is often mislabeled as the “good cancer” [1-3] due to the excellent 5-year survival rates compared to other cancers [4]. Differentiated thyroid cancer (DTC) is the most common endocrine malignancy among the estimated 44,020 new cases of thyroid cancer in the United States annually [4]. DTC involves a spectrum of disease presentations characterized by different levels of risk of recurrence.

Alaina L Carr, Angela M Jenkins, Jacqueline Jonklaas, Kate Gabriel, Kristen E Miller, Kristi D Graves

JMIR Form Res 2025;9:e60588

A Hybrid Deep Learning–Based Feature Selection Approach for Supporting Early Detection of Long-Term Behavioral Outcomes in Survivors of Cancer: Cross-Sectional Study

A Hybrid Deep Learning–Based Feature Selection Approach for Supporting Early Detection of Long-Term Behavioral Outcomes in Survivors of Cancer: Cross-Sectional Study

The number of survivors of cancer is increasing globally. The American Cancer Society recently reported that in 2023, a total of 1,958,310 new cancer cases were projected to occur in the United States [1]. Treatment advances have resulted in a dramatic improvement in the survival rates of most cancers, especially in resource-limited countries and regions.

Tracy Huang, Chun-Kit Ngan, Yin Ting Cheung, Madelyn Marcotte, Benjamin Cabrera

JMIR Bioinform Biotech 2025;6:e65001