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Challenges With the Use of Digital Sham: Systematic Review and Recommendations
In the field of neuroscience (including neurodevelopmental, neurodegenerative, and psychiatric disorders):
How has digital sham been used in clinical research?
What proportion of DTx studies involved digital sham?
What was the objective of using digital sham in the study or in the larger developmental plan of the manufacturer?
What was the nature of digital sham used in these studies? Was the digital sham validated before its use in clinical trials?
J Med Internet Res 2023;25:e44764
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