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Mixed Reality–Based Physical Therapy in Older Adults With Sarcopenia: Preliminary Randomized Controlled Trial

Mixed Reality–Based Physical Therapy in Older Adults With Sarcopenia: Preliminary Randomized Controlled Trial

While MR-based interventions have been explored extensively in the fields of neurorehabilitation and motor recovery, evidence supporting their use in geriatric physical therapy—particularly for sarcopenia management—is scarce. Thus, this study aimed to evaluate and compare the effects of Mr.PT and conventional physical activity (CPA) programs on quadricep muscle thickness, balance confidence, ADL independence, and QOL among older adults with sarcopenia.

Yeongsang An, Seunghwa Min, Chanhee Park

JMIR Serious Games 2025;13:e76357

Peer Review of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

Peer Review of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

This is a peer-review report for “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study.” This paper [1] conducted a validation to derive a cutoff value that predicted low grip strength from SARC-F (strength, assistance with walking, rising from a chair, climbing stairs, and falls) scores and showed that the cutoff for SARC-F scores is 2 points. Many issues need to be resolved before this study can be published.

Anonymous

JMIRx Med 2025;6:e77582

Authors’ Response to Peer Reviews of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

Authors’ Response to Peer Reviews of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

This is the authors’ response to peer-review reports for “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study.” 1. Introduction: Add a discussion on current research gaps (eg, sarcopenia screening) and clearly explain how your study [2] addresses these gaps. Response: Done. 2.

David Propst, Lauren Biscardi, Tim Dornemann

JMIRx Med 2025;6:e77497

Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study

Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study

The severity of muscle mass and strength loss in sarcopenia has been shown to be associated with a decreased ability to complete activities of daily living, lower quality of life, and substantially higher health care costs [5,6]. In 2018, the second European Working Group on Sarcopenia in Older People (EWGSOP2) defined a multifactorial approach to identifying sarcopenia by finding, assessing, confirming, and testing for severity [6].

David Propst, Lauren Biscardi, Tim Dornemann

JMIRx Med 2025;6:e54475

Peer Review of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

Peer Review of “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study”

This is the peer-review report for “Assessment of SARC-F Sensitivity for Probable Sarcopenia Among Community-Dwelling Older Adults: Cross-Sectional Questionnaire Study.” The authors [1] present an intriguing and clinically valuable finding through their receiver operating characteristic (ROC) curve analysis, suggesting that a SARC-F (strength, assistance with walking, rising from a chair, climbing stairs, and falls) score of ≥2 may serve as a new cutoff value for screening probable sarcopenia.

Anonymous

JMIRx Med 2025;6:e78552

Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis

Sarcopenia, characterized by accelerated loss of muscle mass and deterioration in function, is a prevalent skeletal muscle disorder in the elderly [8]. As predicted by statistics, about 2 billion individuals globally will be affected by sarcopenia by 2050 [9].

Tingting Sha, Yuqing Zhang, Jie Wei, Changjun Li, Chao Zeng, Guanghua Lei, Yilun Wang

JMIR Aging 2025;8:e66031

The Relationship Between Sleep Disorders and Combination of Diabetes and Sarcopenia in Adults Aged 45 Years or Older: 10-Year Nationwide Prospective Cohort Study

The Relationship Between Sleep Disorders and Combination of Diabetes and Sarcopenia in Adults Aged 45 Years or Older: 10-Year Nationwide Prospective Cohort Study

A venous FPG value ≥7.0 mmol/L was classified as diabetes, FPG ≥6.1 mmol/L and The Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment (AWGS 2019) was used to assess the status of the sarcopenia and classify participants into sarcopenia, possible sarcopenia, and nonsarcopenia groups. The average of maximum values of handgrip strength was measured using either or both hands to evaluate the skeletal muscle strength.

Shugang Li, Yimi Wang, Linzhi Li, Hao Wu

JMIR Aging 2025;8:e66372

Systemic Inflammation and Disruption of the Local Microenvironment Compromise Muscle Regeneration: Critical Pathogenesis of Autoimmune-Associated Sarcopenia

Systemic Inflammation and Disruption of the Local Microenvironment Compromise Muscle Regeneration: Critical Pathogenesis of Autoimmune-Associated Sarcopenia

However, the exact cause of primary sarcopenia is not fully understood yet. Recent studies suggested that cellular aging [7], mitochondrial disorder [8], decreased physical activity [9], and excessive caloric intake could accelerate the progression of sarcopenia. Moreover, an imbalance of oxygen in the body may contribute to the development of sarcopenia as well [10]. Sarcopenia afflicts not only the older people but also the patients with immune diseases.

Yingjuan Zhang, Qingqian Wu, Yi Wang, Qingyan Chen, Shuang Han, Bei Li, Qingwen Zhao, Qianzhuo Wang, Yule Wang, Yue Gao

Interact J Med Res 2025;14:e64456

Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study

Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study

Sarcopenia significantly influences the secretion and metabolism of the body, such as glucose, glycogen, and lipid metabolism, as well as the secretion of a variety of cytokines [5]. Therefore, clinical data from laboratory information may provide supplementary information for the diagnosis of sarcopenia. Besides the metabolic changes, the pathogenesis of sarcopenia primarily encompasses fiber loss, atrophy, and increased infiltration of adipose and connective tissue [6,7].

Zi-Tong Chen, Xiao-Long Li, Feng-Shan Jin, Yi-Lei Shi, Lei Zhang, Hao-Hao Yin, Yu-Li Zhu, Xin-Yi Tang, Xi-Yuan Lin, Bei-Lei Lu, Qun Wang, Li-Ping Sun, Xiao-Xiang Zhu, Li Qiu, Hui-Xiong Xu, Le-Hang Guo

J Med Internet Res 2025;27:e70545