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- 290 JMIR Research Protocols
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This protocol describes a planned meta-analysis to systematically evaluate the effect of obesity on the perioperative outcomes following lung cancer surgery. The primary outcome is postoperative 30-day mortality; the secondary outcomes are postoperative complications, average length of stay, blood loss during operation, and operation time. This study aims to provide evidence-based insights to guide preoperative risk assessment and optimize patient care.
JMIR Res Protoc 2025;14:e76315
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This protocol paper only covers the quantitative element of the study. As in previous phases, qualitative themes will be guided by preliminary descriptive quantitative analyses which will identify potential areas of inquiry. These areas can then be explored in depth using qualitative methods, providing further insight into the underlying drivers of patterns revealed by the survey.
JMIR Res Protoc 2025;14:e77460
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To examine the built environment of this specialized hospice care (Maggie’s Lodge), we developed an Aging in the Right Place-Hospice Environmental Assessment Protocol (AIRP-HEAP) tool.
End-of-life in the right place is an extension of the Aging in the Right Place (AIRP) project, which emphasizes the significance of secure and optimal housing that assists an individual’s unique vulnerabilities [12].
JMIR Res Protoc 2025;14:e73356
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Figure 2 presents the combined SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 schedule of enrollment, interventions, and assessments for the full 36-week study. Consistent with the SPIRIT 2013 recommendations, the figure maps all key events across 2 action research cycles: cycle 1 (weeks 1-18) and cycle 2 (weeks 19-36).
JMIR Res Protoc 2025;14:e80290
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This protocol will be conducted in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocol) statement (Multimedia Appendix 1) and has been prospectively registered on PROSPERO (registration: CRD42024558671). All randomized controlled trials will be included, irrespective of their publication status or language.
JMIR Res Protoc 2025;14:e69527
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The primary analysis will include all participants randomized based on the intention to treat analysis and a sensitivity per-protocol analysis will also be performed. A priori, the primary analysis will be adjusted for baseline pain scores using the analysis of covariance (ANCOVA). Generalized estimating equations will be used to examine the impact of baseline pain score on v NRS outcomes across the entire time frame.
JMIR Res Protoc 2025;14:e76554
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All components of this project involving human participants are approved through Wake Forest University School of Medicine institutional review board protocol (IRB00130700). We follow the Standards for Reporting Implementation Studies for all aims.
We will use an implementation mapping (IM) approach to complete the FOCUS project (Figure 1).
JMIR Res Protoc 2025;14:e73718
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The study, research protocol, and informed consent form were approved by the Medical Ethics Committee of the First Affiliated Hospital of Henan University of Science and Technology in December 2024 (2024-03-K171), and the study will be conducted in accordance with the Declaration of Helsinki.
To rigorously ensure comprehension and voluntariness among patients who may be experiencing frailty, cognitive impairment, or treatment-related distress, we will implement an enhanced consent process.
JMIR Res Protoc 2025;14:e76628
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The protocol of this meta-analysis will be conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) statement guidelines [33]. The PRISMA-P checklist is shown in Multimedia Appendix 1. This meta-analysis protocol was registered in PROSPERO (CRD42024562477).
This meta-analysis will include RCTs reporting r TMS interventions based on rs-f MRI for improving PSCI.
JMIR Res Protoc 2025;14:e77931
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This randomized clinical trial protocol aims to evaluate the effectiveness of T-PRF and CTGs harvested from the tuberosity area using M-VISTA for the management of human GR defects with regards to root coverage (RC), gain in clinical attachment level (CAL), gingival thickness (GT), and improvement in the width of keratinized gingiva (WKG).
This study is a randomized clinical trial and will be performed over a period of 2 years.
JMIR Res Protoc 2025;14:e67168
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