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High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial

High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial

The prevalence of type 2 diabetes is increasing globally [1-3], driven predominantly by a rising number of individuals with prediabetes [2]. Globally, an estimated 860 million (8.4%) adults are living with prediabetes, a condition that increases the risk of developing type 2 diabetes [2], micro- and macrovascular complications, and mortality [4]. Prediabetes is not a singular entity but rather a heterogeneous group of metabolic defects that often precede type 2 diabetes [5-7].

Sathish Thirunavukkarasu, Thomas R Ziegler, Mary Beth Weber, Lisa Staimez, Felipe Lobelo, Mindy L Millard-Stafford, Michael D Schmidt, Aravind Venkatachalam, Ram Bajpai, Farah El Fil, Maria Prokou, Siya Kumar, Robyn J Tapp, Jonathan E Shaw, Francisco J Pasquel, Joe R Nocera

JMIR Res Protoc 2025;14:e59842

Involving End Users in the Development and Usability Testing of a Smartphone App Designed for Individuals With Prediabetes: Mixed-Methods Focus Group Study

Involving End Users in the Development and Usability Testing of a Smartphone App Designed for Individuals With Prediabetes: Mixed-Methods Focus Group Study

Small Steps for Big Changes is a community-based diabetes prevention program designed for individuals with prediabetes [10]. Small Steps for Big Changes is delivered in 6 sessions over 4 weeks using a client-centered counseling style known as motivational interviewing with follow-ups over 12 months. Clients work one-on-one with their coach to cover several topics including goal setting, healthy food choices, and exercise adherence.

Natalie Grieve, Kyra Braaten, Megan MacPherson, Sam Liu, Mary E Jung

JMIR Form Res 2025;9:e59386

Perceptions and Experiences of Developing Prediabetes Awareness and Participating in the National Diabetes Prevention Program Among Hispanic US Adults: Qualitative Study

Perceptions and Experiences of Developing Prediabetes Awareness and Participating in the National Diabetes Prevention Program Among Hispanic US Adults: Qualitative Study

Prediabetes is a state of elevated blood glucose that conveys an increased risk for subsequently developing type 2 diabetes (T2 D) [1]. In the United States, approximately 97.6 million adults have prediabetes (38% of the entire population) [2]. Among adults with prediabetes, an estimated 29% will develop T2 D within 3 years, and 70% will develop T2 D within their lifetime without an effective strategy for primary prevention [3,4].

Kevin L Joiner, Mackenzie Adams, Edith Beltrán Minehan, Matthew J O'Brien

JMIR Form Res 2025;9:e66964

The Integrating Cultural Aspects Into Diabetes Education (INCLUDE) Study to Prevent Diabetes in Chinese Immigrants: Protocol for a Randomized Controlled Trial

The Integrating Cultural Aspects Into Diabetes Education (INCLUDE) Study to Prevent Diabetes in Chinese Immigrants: Protocol for a Randomized Controlled Trial

As the largest Asian and Pacific Islander subgroup, Chinese immigrants bear high T2 D and prediabetes burdens, particularly in New York City (NYC), where almost 1 in every 2 Chinese adults has T2 D or prediabetes [8,9]. Additionally, 18% of Chinese adults in NYC who are aged 18 years and older live in poverty; this burden is particularly pronounced among those aged 65 years and older, where 30% live in poverty [10].

Lu Hu, Nelson F Lin, Yun Shi, Jiepin Cao, Mary Ann Sevick, Huilin Li, Jeannette M Beasley, Natalie Levy, Kosuke Tamura, Xinyi Xu, Yulin Jiang, Iris Ong, Ximin Yang, Yujie Bai, Liwen Su, Sze Wan Chan, Stella S Yi

JMIR Res Protoc 2024;13:e65455

Objective Analysis of Traditional Chinese Medicine Syndrome Differentiation of Patients With Diabetes and Prediabetes: Protocol for a Nonrandomized, Exploratory, Observational Case-Control Study Using Digitalized Traditional Chinese Medicine Diagnostic Tools

Objective Analysis of Traditional Chinese Medicine Syndrome Differentiation of Patients With Diabetes and Prediabetes: Protocol for a Nonrandomized, Exploratory, Observational Case-Control Study Using Digitalized Traditional Chinese Medicine Diagnostic Tools

Prediabetes (intermediate hyperglycemia), characterized by a glycemic level between normal glucose tolerance and diabetes, maintains a high risk of developing diabetes, with an annual conversion rate of 5%-10% [3]. Table 1 provides the World Health Organization (WHO) diagnostic standards defined for diabetes and prediabetes [4]. The American Diabetes Association also states that the glycated hemoglobin A1c (Hb A1c) level should be at or above 6.5% for diabetes and between 5.7% and 6.4% for prediabetes [5].

Hui Ping Ng, Shu Yun Chong, Yi Huan Li, Tong Hwee Goh, Ka Yii Pang, Michelle Jessica Pereira, Chin-Ming Huang

JMIR Res Protoc 2024;13:e56024

Effects of Lifestyle Interventions on Cardiovascular Disease Risk and Risk Factors Among Individuals at High Risk for Type 2 Diabetes: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Lifestyle Interventions on Cardiovascular Disease Risk and Risk Factors Among Individuals at High Risk for Type 2 Diabetes: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials

Individuals with a high risk of developing type 2 diabetes, such as those with prediabetes, also face an elevated risk of experiencing CVD events [4], with higher incidence rates than the general population [5,6]. Consequently, it is imperative to implement interventions for the primary prevention of CVDs among those at high risk for type 2 diabetes [7,8].

Getu Debalkie Demissie, Josephine Birungi, Tilahun Haregu, Sathish Thirunavukkarasu, Brian Oldenburg

JMIR Res Protoc 2024;13:e53517

Inequalities in the Ability for People With Type 2 Diabetes and Prediabetes to Adapt to the Reduction in In-Person Health Support and Increased Use of Digital Support During the COVID-19 Pandemic and Beyond: Qualitative Study

Inequalities in the Ability for People With Type 2 Diabetes and Prediabetes to Adapt to the Reduction in In-Person Health Support and Increased Use of Digital Support During the COVID-19 Pandemic and Beyond: Qualitative Study

In the United Kingdom, 1 in 10 people older than 40 years now has T2 D and around a third of adults living in England have prediabetes [1]. Prediabetes puts individuals at high risk of developing T2 D and the associated health complications [2], including cardiovascular pathologies, kidney disease, eye problems, and foot ulcers [3]. The COVID-19 pandemic created unprecedented challenges for people with T2 D and prediabetes to access in-person health care and self-care support in the United Kingdom [4,5].

Sophie Turnbull, Christie Cabral

JMIR Diabetes 2024;9:e55201

Characterizing Technology Use and Preferences for Health Communication in South Asian Immigrants With Prediabetes or Diabetes: Cross-Sectional Descriptive Study

Characterizing Technology Use and Preferences for Health Communication in South Asian Immigrants With Prediabetes or Diabetes: Cross-Sectional Descriptive Study

To be eligible for the parent study, participants had to: (1) self-identify as South Asian; (2) be between 21-75 years old; (3) have an appointment with a physician for routine nonemergency primary care in the last 12 months; (4) have a diagnosis of diabetes for at least 12 months (for diabetes study participants); (5) have an Hb A1c of at least 7% in the last 12 months (for diabetes study participants); and (6) have a BMI of ≥23 kg/m2, as the threshold for overweight for Asian individuals [33] (for prediabetes

Lu Hu, Laura C Wyatt, Farhan Mohsin, Sahnah Lim, Jennifer Zanowiak, Shinu Mammen, Sarah Hussain, Shahmir H Ali, Deborah Onakomaiya, Hayley M Belli, Angela Aifah, Nadia S Islam

JMIR Form Res 2024;8:e52687

The Key Digital Tool Features of Complex Telehealth Interventions Used for Type 2 Diabetes Self-Management and Monitoring With Health Professional Involvement: Scoping Review

The Key Digital Tool Features of Complex Telehealth Interventions Used for Type 2 Diabetes Self-Management and Monitoring With Health Professional Involvement: Scoping Review

As prediabetes is characterized by elevated blood glucose levels that do not yet meet the diagnostic criteria for diabetes, the therapeutic management of diabetes and prediabetes is similar [4,5]. In both cases, a comprehensive approach is required to better control glycemia levels [6,7].

Choumous Mannoubi, Dahlia Kairy, Karla Vanessa Menezes, Sophie Desroches, Geraldine Layani, Brigitte Vachon

JMIR Med Inform 2024;12:e46699

Tailoring of Health-Promotion Video Messaging for Reproductive-Aged Women at Risk for Developing Cardiometabolic Disease: Qualitative Focus-Groups Study

Tailoring of Health-Promotion Video Messaging for Reproductive-Aged Women at Risk for Developing Cardiometabolic Disease: Qualitative Focus-Groups Study

However, very few adults with prediabetes participate in the DPP and reproductive-aged women are 50% less likely to participate than older women [8]. Our team earlier developed a 360° video to increase risk perception of T2 D. The video helps participants conceptualize T2 D complications throughout the lifespan and is designed to promote DPP enrollment among at-risk adults. It was developed with input from Hispanic community members and was not designed specifically for reproductive-aged women [9].

Jacqueline Kent-Marvick, Bryan Gibson, Alycia A Bristol, Stephanie St Clair, Sara E Simonsen

JMIR Form Res 2024;8:e52583