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Pain typology can be distinguished as neuropathic, mechanical or nociceptive, or nociplastic, where neuropathic is characterized by pain caused by a lesion or disease of the somatosensory nervous system, mechanical or nociceptive pain occurs with a normally functioning somatosensory nervous system, and nociplastic is defined as pain arising from the altered function of pain-related sensory pathways in the periphery and central nervous system [16,17].
J Med Internet Res 2025;27:e62786
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Melatonin for Neuropathic Pain: Protocol for a Double-blind, Randomized Controlled Trial
Neuropathic pain (NP) is a common form of secondary chronic pain due to a lesion or disease of the nervous system [1] such as diabetic neuropathy, spinal radiculopathy, HIV-neuropathy, postherpetic neuralgia, and cancer-related conditions [2]. NP has been estimated to have a prevalence of 7%-8% [3] and is known to impair physical, social, and occupational function with a subsequent devastating impact on patients, their families, and society [4,5].
JMIR Res Protoc 2022;11(9):e40025
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