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Skip search results from other journals and go to results- 3 JMIR Research Protocols
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Melatonin was the most common single treatment term, with 15,005 mentions, followed by terms related to CBT-I, with 13,461 mentions. When time trends were evaluated with RE, terms related to CBT-I spiked in 2017-2018, with a slight decrease and plateau from 2020 onward (Figure 2); the term “hygiene” alone, however, had less variable patterns (Figure S3 in Multimedia Appendix 1).
J Med Internet Res 2025;27:e58902
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Previous studies have linked the action of melatonin on MT1 and MT2 receptors to insulin secretion and sensitivity [17]. Our hypothesis is that melatonin replacement in people with T2 DM who are melatonin deficient may have a positive role in the regulation of insulin, cortisol, and the rhythms of other secretions. If this hypothesis is correct, melatonin replacement may reduce the range of blood glucose variation throughout the day.
JMIR Res Protoc 2023;12:e47887
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Importantly, clinical trials of melatonin therapy for sleep have found that not all participants benefit equally from treatment with melatonin. Several meta-analyses assessing the efficacy of melatonin therapy found evidence for significant heterogeneity in the effectiveness of melatonin interventions, particularly for outcomes including sleep onset latency, total sleep duration, and sleep efficiency [25,26].
JMIR Res Protoc 2023;12:e45313
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Melatonin for Neuropathic Pain: Protocol for a Double-blind, Randomized Controlled Trial
A review of studies involving varying doses [21] reported that oral administration of melatonin results in a transport maximum ranging 15-210 minutes, and a half-life ranging 28-126 minutes [21].
Thus, in the interest of further evaluating the analgesic efficacy of melatonin for NP, our objective is to conduct a double-blind RCT to compare the efficacy of melatonin to that of placebo in patients with chronic neuropathic conditions.
JMIR Res Protoc 2022;11(9):e40025
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