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Digital Tracking of Physical Activity, Heart Rate, and Inhalation Behavior in Patients With Pulmonary Arterial Hypertension Treated With Inhaled Iloprost: Observational Study (VENTASTEP)

Digital Tracking of Physical Activity, Heart Rate, and Inhalation Behavior in Patients With Pulmonary Arterial Hypertension Treated With Inhaled Iloprost: Observational Study (VENTASTEP)

Further aims were to digitally monitor heart rate and iloprost inhalation behavior, to explore temporal patterns in activity level and heart rate relative to iloprost inhalation periods, and to evaluate changes in clinical outcome measures, daily physical activity, heart rate, and sleep quality after initiation of inhaled iloprost therapy. The study was not designed to investigate or confirm the effectiveness and safety of iloprost (Ventavis).

Barbara Stollfuss, Manuel Richter, Daniel Drömann, Hans Klose, Martin Schwaiblmair, Ekkehard Gruenig, Ralf Ewert, Martin C Kirchner, Frank Kleinjung, Valeska Irrgang, Christian Mueller

J Med Internet Res 2021;23(10):e25163

Evaluation of Clinical Outcomes and Simultaneous Digital Tracking of Daily Physical Activity, Heart Rate, and Inhalation Behavior in Patients With Pulmonary Arterial Hypertension Treated With Inhaled Iloprost: Protocol for the Observational VENTASTEP Study

Evaluation of Clinical Outcomes and Simultaneous Digital Tracking of Daily Physical Activity, Heart Rate, and Inhalation Behavior in Patients With Pulmonary Arterial Hypertension Treated With Inhaled Iloprost: Protocol for the Observational VENTASTEP Study

The recently approved Breelib nebulizer (Vectura Group plc) for administration of iloprost saves inhalation data, thus allowing digital monitoring of adherence [20,21]. This study aims to perform parallel digital tracking of daily physical activity parameters, heart rate, and iloprost inhalation data in patients with PAH, before and after starting treatment with inhaled iloprost.

Christian Mueller, Barbara Stollfuss, Alexander Roitenberg, Jonas Harder, Manuel J Richter

JMIR Res Protoc 2019;8(4):e12144