e.g. mhealth
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For instance, the role of other environmental, genetic, or lifestyle factors in breast cancer development is not adequately considered. Acknowledging and discussing these potential confounders would provide a more comprehensive understanding of the complex etiology of breast cancer.
While the paper cites a significant amount of relevant literature, it sometimes overlooks recent studies that could either support or challenge the proposed hypotheses.
JMIRx Med 2025;6:e70041
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This could include molecular or genetic profiling comparisons.
The discussion section should address not only the supporting evidence but also any contradictory findings in the literature. This balance is crucial for a nuanced understanding of the subject.
The implications of these findings are profound but need clearer articulation. Discuss the potential impact on breast cancer treatment and prevention strategies.
JMIRx Med 2025;6:e70039
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This could include molecular or genetic profiling comparisons.
Response: I added a more detailed comparative analysis with results in Figure 2 H and Table S2, as described on page 10.
The discussion section should address not only the supporting evidence but also any contradictory findings in the literature. This balance is crucial for a nuanced understanding of the subject.
JMIRx Med 2025;6:e69307
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Histones are chromatin structures that SWI-SNF dynamically remodels to regulate access to genetic information. Histones can profoundly affect metastasis [78]. Figure 9 also reveals many additional alignments between breakpoints in breast and EBV-associated cancers that were not investigated further.
NPC often inactivates SWI-SNF components BAP1 and PBRM1 within a frequently damaged 3p21.3 gene cluster [11] at 52,400,000‐53,000,000 on chromosome 3.
JMIRx Med 2025;6:e50712
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TBDs are rare, genetic conditions that affect both pediatric and adult populations, with most patients experiencing symptoms before the age of 20 [10-12]. Dyskeratosis congenita (DC), the classic TBD diagnosis, is identified by a triad of nail dysplasia, abnormal skin pigmentation, and oral leukoplakia; however, not all individuals with TBDs exhibit these traits.
JMIR Form Res 2024;8:e64343
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In genetic medicine, which requires specialized expertise, chatbots can collect family medical history and assist HCPs in communicating with at-risk relatives [3,4]. However, practical implementation in genetic medicine remains limited, particularly in Japan. We developed a chatbot for preliminary screening of hereditary breast and ovarian cancer (HBOC) [5] and conducted a clinical study to validate its feasibility and potential usefulness in a clinical setting with real patients.
J Med Internet Res 2024;26:e48914
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A comparative analysis of how different cell lines undergo immortalization, their genetic integrity, and their response to viral infections could provide a more nuanced understanding.
6. Extending the functional characterization of the fetal ovine heart–Saudi Arabia (FOH-SA) cell line to include its capability for differentiation and response to various external factors would add value.
7.
JMIRx Bio 2024;2:e63336
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A comparative analysis of how different cell lines undergo immortalization, their genetic integrity, and their response to viral infections could provide a more nuanced understanding.
Response: The exact mechanisms that led to spontaneous immortalization of most animal cell lines remained unexplained, and the results of this study gave an explanation of how the Vero cell line was established, and this might encourage researchers to further investigate into this area.
6.
JMIRx Bio 2024;2:e62911
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The paper mentions a large-scale genetic conversion leading to high homozygosity in single-nucleotide polymorphism genotypes. What are the potential implications of this genetic conversion on the behavior and stability of the cell line, particularly in terms of its use in vaccine production and biotechnological applications?
4. How was the FOH-SA cell line authenticated at the European Collection of Authenticated Cell Cultures?
JMIRx Bio 2024;2:e62905
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