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In this quantitative and qualitative observational study, we have focused on tweets that referenced the weak opioids tramadol and codeine. Paracetamol was chosen as the control drug due to its efficacy in different types of pain, its safety profile, its extensive clinical use in a wide range of patients, and its availability and accessibility.
J Med Internet Res 2023;25:e45660
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Impact of Removing Nonprescription Codeine in Australia: Protocol for a Prospective Cohort Study
Despite its wide use, there are a number of concerns about codeine as an analgesic, with risks of prolonged misuse of OTC codeine-ibuprofen products including life-threatening complications such as gastric bleeds, renal failure, hypokalemia, and opioid dependence [3,4].
In addition to risk of serious harm, there is limited evidence for the addition of low-dose codeine (16 to 25 mg of codeine per dose) to paracetamol or ibuprofen preparations for improved pain relief [5-9].
JMIR Res Protoc 2020;9(3):e15540
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Codeine Addiction and Internet Forum Use and Support: Qualitative Netnographic Study
Research has explored how individuals communicate and discuss narratives of codeine misuse and experimentation. This has been identified through written posts about codeine trips [13] and glamorizing codeine misuse through images and specific media, such as Instagram [14] or Twitter for illegal prescription opioid sales [15]. Such insights do not capture how the internet is used to seek support for misuse of medicines such as codeine.
JMIR Ment Health 2019;6(4):e12354
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