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Circadian Reinforcement Therapy in Combination With Electronic Self-Monitoring to Facilitate a Safe Postdischarge Period for Patients With Major Depression: Randomized Controlled Trial

Circadian Reinforcement Therapy in Combination With Electronic Self-Monitoring to Facilitate a Safe Postdischarge Period for Patients With Major Depression: Randomized Controlled Trial

We developed a CRT based on the knowledge from chronobiology and chronotherapy of zeitgebers, light pathways in the brain and their relationship to mood [23], the phase response curve of light [12], and sleep regulation [24]. There is evidence that not only are rhythms such as sleep and melatonin and temperature curves distorted in major depression, but there are also changes in circadian gene expression in the brain [7].

Anne Sofie Aggestrup, Signe Dunker Svendsen, Anne Præstegaard, Philip Løventoft, Lasse Nørregaard, Ulla Knorr, Henrik Dam, Erik Frøkjær, Konstantin Danilenko, Ida Hageman, Maria Faurholt-Jepsen, Lars Vedel Kessing, Klaus Martiny

JMIR Ment Health 2023;10:e50072

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Clinical Relevance of the First Domomedicine Platform Securing Multidrug Chronotherapy Delivery in Metastatic Cancer Patients at Home: The inCASA European Project

Clinical Relevance of the First Domomedicine Platform Securing Multidrug Chronotherapy Delivery in Metastatic Cancer Patients at Home: The inCASA European Project

Toward this goal, cancer chronotherapy protocols use dedicated multichannel programmable-in-time pumps [13,14]. Thus, chronotherapy usually involves the chronomodulated delivery of chemotherapeutic agents according to circadian rhythms in nonhospitalized patients [13,15]. Doublet and triplet chronomodulated regimens have been safely administered at the patient’s home, resulting in improved tolerability and efficacy [16-19].

Pasquale F Albert Innominato, Sandra Komarzynski, Ali Mohammad-Djafari, Alexandre Arbaud, Ayhan Ulusakarya, Mohamed Bouchahda, Mazen Haydar, Rachel Bossevot-Desmaris, Virginie Plessis, Magali Mocquery, Davina Bouchoucha, Mehran Afshar, Jacques Beau, Abdoulaye Karaboué, Jean-François Morère, Joanna Fursse, Jordi Rovira Simon, Francis Levi

J Med Internet Res 2016;18(11):e305

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Article has an altmetric score of 5