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The nonmotor symptoms of PD include neurobehavioral changes (eg, depression and cognitive impairment), autonomic failure (eg, urinary dysfunction and abnormal blood pressure), sleep disorders (eg, insomnia and excessive daytime sleeping), sensory impairments (eg, problems with vision and smell), weight loss, and fatigue [3,7]. Nonmotor symptoms can appear throughout the disease trajectory of PD and may even appear before PD is diagnosed [7].
J Med Internet Res 2025;27:e62822
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