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At-Home Virtual Reality Intervention for Patients With Chronic Musculoskeletal Pain: Single-Case Experimental Design Study

At-Home Virtual Reality Intervention for Patients With Chronic Musculoskeletal Pain: Single-Case Experimental Design Study

A single-case experimental design (SCED) study could increase understanding of the individual experience [14]. SCED studies apply detailed assessment at numerous timepoints [15] and have benefits over other designs, including patients serving as their own control and being especially suitable for heterogeneous samples, like CMP patients with a variety of conditions [16].

Syl Slatman, Lieke Heesink, Reinoud Achterkamp, José Broeks, Nelson Monteiro de Oliveira, Remko ter Riet, Marjolein Stegeman, Monique Tabak

JMIR XR Spatial Comput 2025;2:e58784

Internet-Delivered Therapy for Parents With Health Anxiety by Proxy: Protocol for a Single-Case Experimental Design Study

Internet-Delivered Therapy for Parents With Health Anxiety by Proxy: Protocol for a Single-Case Experimental Design Study

Single-case experimental design (SCED) studies are used in clinical psychology to determine whether an effect of an intervention at an individual level has occurred [23-25]. Thus, a SCED study allows testing the effect of treatment for parents with HA by proxy in a small sample size while still controlling for external factors and upholding internal validity [26]. Consequently, this paper aims to describe the design for the first testing of PROXY using a SCED.

Katrine Ingeman, Lisbeth Frostholm, Kaare Bro Wellnitz, Kristi Wright, Ditte Hoffmann Frydendal, Patrick Onghena, Charlotte Ulrikka Rask

JMIR Res Protoc 2023;12:e46927

StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials

StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials

In the literature, N-of-1 trials are sometimes used as a synonym for single-case experimental designs (SCEDs), mainly in the United Kingdom, but mostly used to describe a special case of SCED [7]. N-of-1 trials are well suited for studies when there is large interindividual heterogeneity in treatment effects, as well as when there are subpopulation groups or individuals with comorbidities of interest, who have been excluded from population-level RCTs.

Stefan Konigorski, Sarah Wernicke, Tamara Slosarek, Alexander M Zenner, Nils Strelow, Darius F Ruether, Florian Henschel, Manisha Manaswini, Fabian Pottbäcker, Jonathan A Edelman, Babajide Owoyele, Matteo Danieletto, Eddye Golden, Micol Zweig, Girish N Nadkarni, Erwin Böttinger

J Med Internet Res 2022;24(7):e35884