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A single-case experimental design (SCED) study could increase understanding of the individual experience [14]. SCED studies apply detailed assessment at numerous timepoints [15] and have benefits over other designs, including patients serving as their own control and being especially suitable for heterogeneous samples, like CMP patients with a variety of conditions [16].
JMIR XR Spatial Comput 2025;2:e58784
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Single-case experimental design (SCED) studies are used in clinical psychology to determine whether an effect of an intervention at an individual level has occurred [23-25]. Thus, a SCED study allows testing the effect of treatment for parents with HA by proxy in a small sample size while still controlling for external factors and upholding internal validity [26].
Consequently, this paper aims to describe the design for the first testing of PROXY using a SCED.
JMIR Res Protoc 2023;12:e46927
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StudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials
In the literature, N-of-1 trials are sometimes used as a synonym for single-case experimental designs (SCEDs), mainly in the United Kingdom, but mostly used to describe a special case of SCED [7].
N-of-1 trials are well suited for studies when there is large interindividual heterogeneity in treatment effects, as well as when there are subpopulation groups or individuals with comorbidities of interest, who have been excluded from population-level RCTs.
J Med Internet Res 2022;24(7):e35884
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