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A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

A Data-Driven Reference Standard for Adverse Drug Reaction (RS-ADR) Signal Assessment: Development and Validation

A comprehensive reference standard is required for drug-ADR pairs, equipped with standard vocabulary annotations, in the emerging era of RWD and real-world evidence (RWE). For prevention and management in PV, a strategy for integrating multiple data sources is preferred. Wei et al [24,25] combined Rx Norm, Side Effect Resource (SIDER), Medline Plus, and Wikipedia to compose a medication indication resource (MEDI).

Suehyun Lee, Jeong Hoon Lee, Grace Juyun Kim, Jong-Yeup Kim, Hyunah Shin, Inseok Ko, Seon Choe, Ju Han Kim

J Med Internet Res 2022;24(10):e35464