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Skip search results from other journals and go to results- 29 JMIR Research Protocols
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The frequency of evaluations during a single interaction varied randomly; there were occasions when the chatbot assessed participants’ satisfaction multiple times but on different topics (eg, HIV testing, Pr EP, and mental health). Specifically, the frequency of satisfaction evaluations about the usefulness of the information on HIV testing, Pr EP, and mental health was 53, 52, and 32, respectively.
JMIR Hum Factors 2025;12:e70034
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HIV prevention efforts, such as pre-exposure prophylaxis (Pr EP), often focus predominantly on young MSM, while there is limited literature on the subject regarding older MSM [15,23]. Pr EP has been shown to be effective in preventing HIV among MSM of all ages. For instance, a study conducted in the United States demonstrated that Pr EP is equally effective among young MSM (aged 18‐25 y) and older MSM (aged 26‐50 y) [24].
JMIR Public Health Surveill 2025;11:e58405
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Under this backdrop, it is necessary to develop and test innovative, effective, and culturally appropriate approaches to enhance efforts in fighting against HIV in Cameroon, reduce health disparities, and promote HIV testing and pre-exposure prophylaxis (Pr EP) use among adolescent girls and young women [12].
JMIR Pediatr Parent 2025;8:e69471
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Despite this, current estimates of coverage of Pr EP among Pr EP-eligible MSM fall short of the sustained 30%-50% coverage of Pr EP among MSM that would be required to produce substantial decreases in new HIV infections [2,3]. Pr EP use also varies widely geographically and by race.
JMIR Res Protoc 2025;14:e56096
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In western Kenya, a study of adolescent girls and young women attending family planning clinics found that 76% met Pr EP eligibility criteria, but only 4% initiated Pr EP [16], and the proportion of adolescent girls and young women persisting with Pr EP for 3 months postinitiation ranged from 5% to 37% across studies [7,10,11,15,17]. In samples of Pr EP users at an average of 6 months postinitiation, only 4% to 8% had tenofovir diphosphate (TFVdp) levels suggesting high adherence [4-6].
JMIR Res Protoc 2025;14:e55931
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Lastly, the feasibility measure will indicate how well vlogs can be used to motivate access to Pr EP.
JMIR Public Health Surveill 2025;11:e67367
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Clinical trials of sexual event-driven Pr EP regimens or 2-1-1 Pr EP using F/TDF have demonstrated it to be highly effective for HIV prevention among MSM [3,4]. These options provide MSM with choices about their preferred Pr EP regimen; however, little is known about the Pr EP choices men make, their switching between Pr EP options, and the reasons for these decisions.
Pr EP coverage continues to increase markedly among men [5].
JMIR Res Protoc 2025;14:e64186
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The Pr EP-to-need ratio, defined as the number of Pr EP users divided by new HIV diagnoses [14], is lower in the South than in any other region, particularly among racial and ethnic minorities, further highlighting inequitable access [15].
To decrease HIV incidence, there is a need to improve Pr EP use in populations most heavily impacted by HIV.
JMIR Res Protoc 2025;14:e64813
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In addition, in 2021, Alabama had a Pr EP-to-Need ratio of 5.55, with the highest unmet need for Pr EP occurring among the Black community (Pr EP-to-need ratio among Black vs White individuals: 2.94:11.30) [9].
When focusing on cisgender women, who account for approximately one-fifth of new HIV diagnoses in the United States, only 8% of the 227,010 women with a Pr EP indication are currently receiving Pr EP prescriptions [10-13].
JMIR Res Protoc 2025;14:e58976
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Preexposure prophylaxis (Pr EP) is a highly effective biomedical prevention strategy to reduce HIV incidence and curb the HIV epidemic [3-10]. When taken as prescribed (daily or at least 4 times per week), Pr EP reduces HIV transmission by up to 99% among MSM [7-9,11-13].
JMIR Hum Factors 2025;12:e59780
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