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Limited evaluation: The evaluation is limited to the Open Access Series of Imaging Studies (OASIS) dataset, which may not be representative of the diverse AD population. The authors should evaluate their system on larger and more diverse datasets, such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset, to demonstrate its generalizability.
Insufficient implementation details: The implementation details of the SVMs and ANNs are insufficient.
JMIRx Med 2025;6:e73768
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Limited evaluation: The evaluation is limited to the Open Access Series of Imaging Studies (OASIS) dataset, which may not be representative of the diverse AD population. The authors should evaluate their system on larger and more diverse datasets, such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset, to demonstrate its generalizability.
Response: Done, experiments were achieved by applying the ADNI database. Please see the ADNI Data Set subsection (page 3) for more details on this basis.
JMIRx Med 2025;6:e72821
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In this context, we have experimented the performance of the proposed CAD system on the OASIS [26] and ADNI [27] datasets.
The OASIS dataset [26] was prepared by Dr Randy Buckner from the Howard Hughes Medical Institute at Harvard University, the Neuroinformatics Research Group at Washington University School of Medicine, and the Biomedical Informatics Research Network. OASIS is a longitudinal multimodal neuroimaging, clinical, cognitive, and biomarker dataset for normal aging and AD.
JMIRx Med 2025;6:e60866
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