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Clinical Laboratory Parameter–Driven Machine Learning for Participant Selection in Bioequivalence Studies Among Patients With Gastric Cancer: Framework Development and Validation Study

Clinical Laboratory Parameter–Driven Machine Learning for Participant Selection in Bioequivalence Studies Among Patients With Gastric Cancer: Framework Development and Validation Study

Accordingly, we formulated an ML-based framework to identify participants using the clinical laboratory test values of candidates. In this study, we chose to compare the ML-based method with a random selection method, which we considered representative of the common practice in clinical settings where patient lists are screened sequentially.

Byungeun Shon, Sook Jin Seong, Eun Jung Choi, Mi-Ri Gwon, Hae Won Lee, Jaechan Park, Ho-Young Chung, Sungmoon Jeong, Young-Ran Yoon

JMIR AI 2025;4:e64845

Association Between Risk Factors and Major Cancers: Explainable Machine Learning Approach

Association Between Risk Factors and Major Cancers: Explainable Machine Learning Approach

In conclusion, our study established a predictive framework using EHR data to assess the association between risk factors and cancer outcomes using explainable ML models across major cancer types. We reported critical nontraditional chronic condition risk factors in addition to common demographic risk factors and outlined distinct patterns for each of the 4 cancer types studied. Additionally, we explored the similarities and differences in risk factor patterns across these cancers.

Xiayuan Huang, Shushun Ren, Xinyue Mao, Sirui Chen, Elle Chen, Yuqi He, Yun Jiang

JMIR Cancer 2025;11:e62833

Effectiveness of The Umbrella Collaboration Versus Traditional Umbrella Reviews for Evidence Synthesis in Health Care: Protocol for a Validation Study

Effectiveness of The Umbrella Collaboration Versus Traditional Umbrella Reviews for Evidence Synthesis in Health Care: Protocol for a Validation Study

While AI plays a crucial role, particularly through the use of LLMs and machine learning (ML), it is used selectively within the broader software framework to enhance specific tasks. LLMs are used in generating related search terms, expanding upon human-generated queries to enhance the comprehensiveness of literature searches. Any LLM can be adapted to TU software, up to date we have used Chat GPT 4 [18].

Beltran Carrillo, Marta Rubinos-Cuadrado, Jazmin Parellada-Martin, Alejandra Palacios-López, Beltran Carrillo-Rubinos, Fernando Canillas-Del Rey, Juan Jose Baztán-Cortes, Javier Gómez-Pavon

JMIR Res Protoc 2025;14:e67248