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Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

At the time of development, there was not an easy pathway for this intervention (ie, My Cancer Gene) to integrate with the existing EHR. Furthermore, at the time of development, the use of My Penn Medicine, the institutional patient portal, was relatively limited and for messaging only.

Phillip Trieu, Dominique Fetzer, Briana McLeod, Kathryn Schweickert, Lauren Gutstein, Brian Egleston, Susan Domchek, Linda Fleisher, Lynne Wagner, Kuang-Yi Wen, Cara Cacioppo, Jessica E Ebrahimzadeh, Dana Falcone, Claire Langer, Elisabeth Wood, Kelsey Karpink, Shelby Posen, Enida Selmani, Angela R Bradbury

JMIR Form Res 2025;9:e56282

Prescriptive Predictors of Mindfulness Ecological Momentary Intervention for Social Anxiety Disorder: Machine Learning Analysis of Randomized Controlled Trial Data

Prescriptive Predictors of Mindfulness Ecological Momentary Intervention for Social Anxiety Disorder: Machine Learning Analysis of Randomized Controlled Trial Data

A recent and brief app intervention explanation inspired the rationale for SM as a placebo control [103-105]. Our SM adaptation sought to mimic MEMI while excluding its theorized active therapeutic elements, including acceptance, breath retraining, open monitoring, mindfulness of temporary moments, and regular mindfulness practice.

Nur Hani Zainal, Hui Han Tan, Ryan Yee Shiun Hong, Michelle Gayle Newman

JMIR Ment Health 2025;12:e67210

The Healing Through Ongoing Psychological Empowerment Telehealth Intervention With Two Spirit, Transgender, and Nonbinary Clients of Color in the United States: Open Clinical Trial Feasibility and Implementation Analysis

The Healing Through Ongoing Psychological Empowerment Telehealth Intervention With Two Spirit, Transgender, and Nonbinary Clients of Color in the United States: Open Clinical Trial Feasibility and Implementation Analysis

The HOPE intervention was developed to integrate PRH in psychotherapy for 2 STNB clients who are people of color. Our intervention is grounded in the tenets of the PRH [11,12], and a web-based intervention aimed at reducing internalized transnegativity [13]. Initially, the training developed for this study was piloted with 100 therapists through a program evaluation study [21]. Based on feedback from this pilot, the training was adapted for the 9 therapists for this study.

Stephanie Lynne Budge, Elliot Aaron Tebbe, Joonwoo Lee, Sergio Domínguez Jr, Em Matsuno, Louis Lindley

JMIR Form Res 2025;9:e64477

A Brief Video-Based Intervention to Improve Digital Health Literacy for Individuals With Bipolar Disorder: Intervention Development and Results of a Single-Arm Quantitative Pilot Study

A Brief Video-Based Intervention to Improve Digital Health Literacy for Individuals With Bipolar Disorder: Intervention Development and Results of a Single-Arm Quantitative Pilot Study

One such intervention targeting people with serious mental illness is the 4-week Digital Opportunities for Outcomes in Recovery Services (DOORS) course [24]. However, the length and foundational content of this program (eg, basic smartphone functions) may not be suitable for all individuals with BD, given research showing people with BD have high levels of smartphone ownership [14] and higher digital health literacy than people with psychosis [25].

Emma Morton, Sahil S Kanani, Natalie Dee, Rosemary Xinhe Hu, Erin E Michalak

J Particip Med 2025;17:e59806

Prerequisites for Cost-Effective Home Blood Pressure Telemonitoring: Early Health Economic Analysis

Prerequisites for Cost-Effective Home Blood Pressure Telemonitoring: Early Health Economic Analysis

One of the perceived barriers to large-scale implementation is the lack of a clear reimbursement structure, which is related to a lack of evidence on the cost-effectiveness of this digital health intervention [9]. Clinical trials evaluating the effectiveness of HBPT often have limited follow-up durations [8]. Consequently, they only demonstrate short-term benefits on blood pressure control and do not capture the potential long-term advantages, such as reductions in cardiovascular (CV) events.

Job van Steenkiste, Pim van Dorst, Daan Dohmen, Cornelis Boersma

JMIR Cardio 2025;9:e64386

Effects of Integrating Wearable Activity Trackers With a Home-Based Multicomponent Exercise Intervention on Fall-Related Parameters and Physical Function in Older Adults: Randomized Controlled Trial

Effects of Integrating Wearable Activity Trackers With a Home-Based Multicomponent Exercise Intervention on Fall-Related Parameters and Physical Function in Older Adults: Randomized Controlled Trial

The use of activity trackers, either as the primary element or within a broader behavioral intervention, effectively increases physical activity participation [20]. Moreover, integrating activity trackers with traditional intervention components is more effective than using an activity tracker alone [21]. Despite these advancements, there is a lack of research on the integration of activity trackers with other multifaceted interventions for falls in older adults [22,23].

Yejin Kim, Kyung Hee Park, Hye-Mi Noh

JMIR Mhealth Uhealth 2025;13:e64458

Podcasts in Mental, Physical, or Combined Health Interventions for Adults: Scoping Review

Podcasts in Mental, Physical, or Combined Health Interventions for Adults: Scoping Review

Of the 26 peer-reviewed published studies, only 7 (27%) conducted a podcast-only intervention [66-68,75,80,92,101,102]. The remaining 19 (73%) studies [41,45,64,70,71,73,77,83,86,88-90,100,103-105,107,108,110] used podcasts within a multicomponent intervention (Multimedia Appendix 5).

Elizabeth M Dascombe, Philip J Morgan, Ryan J Drew, Casey P Regan, Gabrielle M Turner-McGrievy, Myles D Young

J Med Internet Res 2025;27:e63360

Telehealth Interventions in Pharmacy Practice: Systematic Review of Reviews and Recommendations

Telehealth Interventions in Pharmacy Practice: Systematic Review of Reviews and Recommendations

Telehealth intervention delivery methods in 18 reviews on telehealth in pharmacy practice. This bar graph illustrates the distribution of different delivery methods used in telehealth interventions across 18 review articles published between August 2012 and December 2024. Telephone-based care was the most widely used method, followed by mobile and web applications. The chart provides a breakdown of the various delivery methods used in teleconsultations, telemonitoring, telesupport, and telecollaboration.

Rachel Lai Kay Chong, Andrew Siang Ee Chan, Crystal Min Siu Chua, Yi Feng Lai

J Med Internet Res 2025;27:e57129

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Adapting a Text Messaging Intervention to Improve Diabetes Medication Adherence in a Spanish-Speaking Population: Qualitative Study

Through this exercise, we found that the priority of some barriers differed in this population compared with the original REACH intervention. For instance, “I’m not sure what my diabetes medicine is supposed to do” was reported as relevant by 61% (11/18) of participants in this study, whereas this barrier was relevant only for 16% (38/237) of participants in the REACH development study [25].

Jacqueline Seiglie, Seth Tobolsky, Ricaurte Crespo Trevino, Lluvia Cordova, Sara Cromer, A Enrique Caballero, Margarita Alegria, J Jaime Miranda, Deborah Wexler, Lindsay Mayberry

JMIR Hum Factors 2025;12:e66668

Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Controlled Trial

Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Controlled Trial

The objective is to compare the effectiveness of a 1-year digital dietary intervention on body weight reduction and improved diet quality, in adults living with obesity delivered by dietitians in a primary care setting, with a control group. The chat2 (Connecting Health and Technology 2) study is a 1-year randomized controlled trial (RCT). Consenting participants will be randomly assigned (1:1) to an intervention or minimal intervention control group.

Deborah A Kerr, Clare E Collins, Andrea Begley, Barbara Mullan, Satvinder S Dhaliwal, Claire E Pulker, Fengqing Zhu, Marie Fialkowski, Richard L Prince, Richard Norman, Anthony P James, Paul Aveyard, Helen Mitchell, Jacquie Garton-Smith, Megan E Rollo, Chloe Maxwell-Smith, Amira Hassan, Hayley Breare, Lucy M Butcher, Christina M Pollard

JMIR Res Protoc 2025;14:e64735