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Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids

Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids

Finally, we calculated Cohen d effect sizes (0.20=small, 0.50=medium, and 0.80=large) [64] to aid interpretation. Across the daily assessments, a similar multilevel modeling approach was used to take advantage of the repeated-measures design. All multilevel models included random intercepts at the participant level and fixed effects of each predictor.

Karlyn A Edwards, Troy C Dildine, Dokyoung S You, Ashley M Herrick, Beth D Darnall, Sean C Mackey, Maisa S Ziadni

JMIR Form Res 2025;9:e68292

Feasibility of Web-Based Single-Session Empowered Relief in Patients With Chronic Pain Taking Methadone or Buprenorphine: Protocol for a Single-Arm Trial

Feasibility of Web-Based Single-Session Empowered Relief in Patients With Chronic Pain Taking Methadone or Buprenorphine: Protocol for a Single-Arm Trial

In a previous single-arm ER pilot study involving mixed etiology chronic pain, a sample size of 57 participants was needed to detect a significant time effect on pain catastrophizing scores at 1 month post treatment (Cohen d=1.15, large effect) [46]. In addition, when conducting a repeated-measures ANOVA with a prior in-person randomized controlled trial (RCT) ER class data only [25], a sample size of 52 was needed to detect a significant time effect.

Morgan R Klein, Beth D Darnall, Dokyoung S You

JMIR Res Protoc 2024;13:e53784

Durability of the Treatment Effects of an 8-Week Self-administered Home-Based Virtual Reality Program for Chronic Low Back Pain: 6-Month Follow-up Study of a Randomized Clinical Trial

Durability of the Treatment Effects of an 8-Week Self-administered Home-Based Virtual Reality Program for Chronic Low Back Pain: 6-Month Follow-up Study of a Randomized Clinical Trial

Effect sizes for the Ease VRx vs sham VR between-group comparison used the standardized mean difference version of Cohen d [17]. For each outcome variable, the effect size of the change pretreatment to 6 months posttreatment was assessed by treatment group using a repeated measures variation of Cohen d as drm owing to the within-subject nature of the comparison [17]. We applied common effect size thresholds of 0.3 (small), 0.5 (medium), and 0.8 (large).

Laura Garcia, Brandon Birckhead, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Vafi Salmasi, Robert Louis, Carina Castro, Roselani Maddox, Todd Maddox, Beth D Darnall

J Med Internet Res 2022;24(5):e37480

Efficacy of a Single-Session “Empowered Relief” Zoom-Delivered Group Intervention for Chronic Pain: Randomized Controlled Trial Conducted During the COVID-19 Pandemic

Efficacy of a Single-Session “Empowered Relief” Zoom-Delivered Group Intervention for Chronic Pain: Randomized Controlled Trial Conducted During the COVID-19 Pandemic

Effect sizes for web-based interventions for chronic pain have been estimated to range from small to moderate (Cohen d range 0.04-1.23) [18]. In addition to CBT, existing web-based interventions for patients with pain include compassionate mind training [22], social media–based web-based community intervention [23], pain self-management [24], and hypnosis [25].

Maisa S Ziadni, Lluvia Gonzalez-Castro, Steven Anderson, Parthasarathy Krishnamurthy, Beth D Darnall

J Med Internet Res 2021;23(9):e29672

An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19

An 8-Week Self-Administered At-Home Behavioral Skills-Based Virtual Reality Program for Chronic Low Back Pain: Double-Blind, Randomized, Placebo-Controlled Trial Conducted During COVID-19

While CBT has not shown efficacy for reducing pain intensity, it has small to moderate effects for reducing depressive symptoms [7], pain bothersomeness [6,7], and pain catastrophizing [6,7] (Darnall et al, unpublished data) in mixed etiology chronic pain as well as c LBP.

Laura M D. Garcia, Brandon J Birckhead, Parthasarathy Krishnamurthy, Josh Sackman, Ian G Mackey, Robert G Louis, Vafi Salmasi, Todd Maddox, Beth D Darnall

J Med Internet Res 2021;23(2):e26292

Correction: Self-Administered Behavioral Skills-Based At-Home Virtual Reality Therapy for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

Correction: Self-Administered Behavioral Skills-Based At-Home Virtual Reality Therapy for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

In the originally published paper, the list of authors appeared as follows: Laura Garcia, Beth Darnall, Parthasarathy Krishnamurthy, Ian Mackey, Josh Sackman, Robert Louis, Todd Maddox, Brandon Birckhead The list has been corrected as follows: Laura M Garcia, Beth D Darnall, Parthasarathy Krishnamurthy, Ian G Mackey, Josh Sackman, Robert G Louis, Todd Maddox, Brandon J Birckhead The correction will appear in the online version of the paper on the JMIR Publications website on February 12, 2021, together with

Laura M James Garcia, Beth D Darnall, Parthasarathy Krishnamurthy, Ian G Mackey, Josh Sackman, Robert G Louis, Todd Maddox, Brandon J Birckhead

JMIR Res Protoc 2021;10(2):e27652

Self-Administered Behavioral Skills–Based At-Home Virtual Reality Therapy for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

Self-Administered Behavioral Skills–Based At-Home Virtual Reality Therapy for Chronic Low Back Pain: Protocol for a Randomized Controlled Trial

However, we note that people with c LBP often report having 2 or more comorbid pain conditions (Darnall et al, unpublished). As such, chronic back pain is not often experienced in isolation. Digital behavioral health treatment studies typically report relatively low treatment engagement rates among participants with rates ranging between 20% and 60% [32,58-60].

Laura M James Garcia, Beth D Darnall, Parthasarathy Krishnamurthy, Ian G Mackey, Josh Sackman, Robert G Louis, Todd Maddox, Brandon J Birckhead

JMIR Res Protoc 2021;10(1):e25291

Self-Administered Skills-Based Virtual Reality Intervention for Chronic Pain: Randomized Controlled Pilot Study

Self-Administered Skills-Based Virtual Reality Intervention for Chronic Pain: Randomized Controlled Pilot Study

Posttreatment effect sizes (baseline to treatment completion at day 21) were computed by treatment group using an adaptation of Cohen d to suit the repeated measures design [49]. The four-item PCS and two-item PSEQ scales were analyzed in a mixed modeling framework, except that there were only 2 time points (baseline day 0 and day 22).

Beth D Darnall, Parthasarathy Krishnamurthy, Jeannette Tsuei, Jorge D Minor

JMIR Form Res 2020;4(7):e17293