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Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

Given both the promise and potential perils of generative AI, this study had two main objectives: (1) to provide an initial demonstration of the technical guardrail success for a DMHI using generative AI and (2) to provide an initial demonstration of maintaining key aspects of the user relationship with a DMHI that uses generative AI.

Timothy R Campellone, Megan Flom, Robert M Montgomery, Lauren Bullard, Maddison C Pirner, Aaron Pavez, Michelle Morales, Devin Harper, Catherine Oddy, Tom O'Connor, Jade Daniels, Stephanie Eaneff, Valerie L Forman-Hoffman, Casey Sackett, Alison Darcy

J Med Internet Res 2025;27:e67365

Needs and Preferences of Swedish Young Adults for a Digital App Promoting Mental Health Literacy, Occupational Balance, and Peer Support: Qualitative Interview Study

Needs and Preferences of Swedish Young Adults for a Digital App Promoting Mental Health Literacy, Occupational Balance, and Peer Support: Qualitative Interview Study

about their mental well-being Teach young adults self-care and peer support strategies in managing mental health challenges Offer young adults direct access to additional mental health resources and support The digital mental health app should be a guide to young adults’ mental well-being Provide safe ways for young adults to interact with others for mutual support and learning Facilitate the sharing of experiences to collectively address mental health needs Cocreate an iterative, empathetic conversational AI

Martin Karaba Bäckström, Sonya Girdler, Ben Milbourn, Annika Lexén

JMIR Form Res 2025;9:e71563

A Comparison of Responses from Human Therapists and Large Language Model–Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study

A Comparison of Responses from Human Therapists and Large Language Model–Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study

Today’s artificial intelligence (AI) chatbots can generally be grouped into 3 categories: AI assistants, AI companions, and AI character platforms. AI assistants are systems that help users with common everyday tasks in both their professional and private lives. AI companions are systems that let users interact with one central chatbot, which is customized over time, and are meant for leisurely or personal conversations.

Till Scholich, Maya Barr, Shannon Wiltsey Stirman, Shriti Raj

JMIR Ment Health 2025;12:e69709

The Effectiveness of a Chatbot Single-Session Intervention for People on Waitlists for Eating Disorder Treatment: Randomized Controlled Trial

The Effectiveness of a Chatbot Single-Session Intervention for People on Waitlists for Eating Disorder Treatment: Randomized Controlled Trial

Then it gave dieting tips(https://www.wsj.com/articles/eating-disorder-chatbot-ai-2aecb179#comments_sector Reference 31: Ethical challenges in AI approaches to eating disordersai

Gemma Sharp, Bronwyn Dwyer, Alisha Randhawa, Isabella McGrath, Hao Hu

J Med Internet Res 2025;27:e70874

Assessing ChatGPT’s Capability as a New Age Standardized Patient: Qualitative Study

Assessing ChatGPT’s Capability as a New Age Standardized Patient: Qualitative Study

Suarez et.al [16] gathered dental student’s feedback after interacting with an AI chatbot. The majority found the experience valuable, especially those who made a correct diagnosis. This underscores the potential of integrating AI into health sciences training [16]. Weidener and Fischer [17] emphasized the growing consensus on incorporating AI into medical education. Their study indicated the importance of both practical and technological skills for leveraging AI in medicine [17].

Joseph Cross, Tarron Kayalackakom, Raymond E Robinson, Andrea Vaughans, Roopa Sebastian, Ricardo Hood, Courtney Lewis, Sumanth Devaraju, Prasanna Honnavar, Sheetal Naik, Jillwin Joseph, Nikhilesh Anand, Abdalla Mohammed, Asjah Johnson, Eliran Cohen, Teniola Adeniji, Aisling Nnenna Nnaji, Julia Elizabeth George

JMIR Med Educ 2025;11:e63353

Digital Biomarkers for Parkinson Disease: Bibliometric Analysis and a Scoping Review of Deep Learning for Freezing of Gait

Digital Biomarkers for Parkinson Disease: Bibliometric Analysis and a Scoping Review of Deep Learning for Freezing of Gait

AI: artificial intelligence; PRISMA-Sc R: Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews; Wo S: Web of Science. The scoping review section of this study follows the PRISMA-Sc R (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines and reports the search strategy used for literature selection [30].

Wenhao Qi, Shiying Shen, Chaoqun dong, Mengjiao Zhao, Shuaiqi Zang, Xiaohong Zhu, Jiaqi Li, Bin Wang, Yankai Shi, Yongze Dong, Huajuan Shen, Junling Kang, Xiaodong Lu, Guowei Jiang, Jingsong Du, Eryi Shu, Qingbo Zhou, Jinghua Wang, Shihua Cao

J Med Internet Res 2025;27:e71560

Assessing the Accuracy and Reliability of Large Language Models in Psychiatry Using Standardized Multiple-Choice Questions: Cross-Sectional Study

Assessing the Accuracy and Reliability of Large Language Models in Psychiatry Using Standardized Multiple-Choice Questions: Cross-Sectional Study

Over the past decade, there has been a significant surge of interest in the application of artificial intelligence (AI), particularly large language models (LLMs), within medical contexts.

Kaitlin Hanss, Karthik V Sarma, Anne L Glowinski, Andrew Krystal, Ramotse Saunders, Andrew Halls, Sasha Gorrell, Erin Reilly

J Med Internet Res 2025;27:e69910

From E-Patients to AI Patients: The Tidal Wave Empowering Patients, Redefining Clinical Relationships, and Transforming Care

From E-Patients to AI Patients: The Tidal Wave Empowering Patients, Redefining Clinical Relationships, and Transforming Care

Many blunt this enthusiasm with caution, as the field struggles to genuinely address AI ethics, accountability, privacy, and governance [2]. Along with the hope (and hype) of AI within health care, the public is swiftly taking AI into their own hands. Consumers are at the forefront in this era of AI. A survey conducted in January 2025 by Imagining the Digital Future Center found that 52% of US adults used Chat GPT, Gemini, Co Pilot, or other LLMs.

Susan S Woods, Sarah M Greene, Laura Adams, Grace Cordovano, Matthew F Hudson

J Particip Med 2025;17:e75794