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Ultrasound-Guided High-Intensity Focused Ultrasound Combined With PD-1 Blockade in Patients With Liver Metastases From Lung Cancer: Protocol for a Single-Arm Phase 2 Trial

Ultrasound-Guided High-Intensity Focused Ultrasound Combined With PD-1 Blockade in Patients With Liver Metastases From Lung Cancer: Protocol for a Single-Arm Phase 2 Trial

A study by Yang et al [34] involving 14 patients with liver metastases from malignancies treated with HIFU and immunotherapy found that this combination was feasible and safe, achieving an ORR of 21.4%. However, only 3 participants had lung cancer, limiting conclusions about the combination’s effectiveness specifically for lung cancer liver metastases. Peripheral blood samples are frequently used in clinical trials for biomarker identification due to the challenge of obtaining tissue specimens.

Chao Hu, Qiang Fu, Fei Fei Gao, Jian Zeng, Wei Xiao, Hui Li, Li Peng, Xi Huang, Li Yang, Wen Zhi Chen, Ming Yan Jiang

JMIR Res Protoc 2024;13:e59152