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Development and External Validation of a Machine Learning Tool to Rule Out COVID-19 Among Adults in the Emergency Department Using Routine Blood Tests: A Large, Multicenter, Real-World Study

Development and External Validation of a Machine Learning Tool to Rule Out COVID-19 Among Adults in the Emergency Department Using Routine Blood Tests: A Large, Multicenter, Real-World Study

The training curve was obtained through 5-fold cross-validation, where positive controls are PCR-confirmed cases during the pandemic (N=2183) and negative controls are prepandemic patients (N=10,000) from 43 hospitals in the PHD. The training AUROC was 0.91 (95% CI 0.90-0.92). The external validation curve was performed in the external validation data set after training the model on the training data set.

Timothy B B Plante, Aaron M Blau, Adrian N Berg, Aaron S Weinberg, Ik C Jun, Victor F Tapson, Tanya S Kanigan, Artur B Adib

J Med Internet Res 2020;22(12):e24048