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This calculation is based on the method outlined by Scott et al [39] and Oetting and Levy [40] and assumes equal marginal variance of outcomes across the ATSs, a normally distributed mean outcome, a type-I error rate of 2.5% where we adjust the standard 0.05 level by a factor of 2 for the 2 primary outcomes of STB, a standardized effect size of 0.50, and no more than 50% attrition by stage 2.
JMIR Res Protoc 2025;14:e68441
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