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Accelerometry-Assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: Cross-Sectional Study

Accelerometry-Assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: Cross-Sectional Study

Figure S5 in Multimedia Appendix 1 demonstrates the correlation plot for all accelerometry measures; the green box demonstrates the temporal profiles of the circadian measures associated with TAC over 24 hours. MESOR, amplitude, and f PC1 are highly correlated with TAC between 9 AM and 8 PM. First 5 functional principal components (f PCs). f PC 2, 3, and 4 values are multiplied by −1.

Nicole Bou Rjeily, Muraleetharan Sanjayan, Pratim Guha Niyogi, Blake E Dewey, Alexandra Zambriczki Lee, Christy Hulett, Gabriella Dagher, Chen Hu, Rafal D Mazur, Elena M Kenney, Erin Brennan, Anna DuVal, Peter A Calabresi, Vadim Zipunnikov, Kathryn C Fitzgerald, Ellen M Mowry

JMIR Mhealth Uhealth 2025;13:e57599