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Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

The NIMH Data Archive (NDA) collection includes data from all eligible participants (N=399) and a small number of participants (n=6, 1.5%) who were later determined not to meet full eligibility criteria (details present in the Data Availability section).

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

We reviewed 102 surgical pathology reports from 102 patients and excluded reports if they were from other organ sites (n=10), benign (n=2), cytopathology (n=5), or outside review (n=1). We included 84 reports for analysis. The study flowchart is shown in Figure 2. Flowchart of the study design and analysis. *The concordance rate was calculated as the total number of concordant answers/total number of answers for each of the 12 medical question answering (MQA).

Denise Lee, Akhil Vaid, Kartikeya M Menon, Robert Freeman, David S Matteson, Michael L Marin, Girish N Nadkarni

JMIR Form Res 2025;9:e64544

Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

Three studies that delivered ICBT recorded participants at risk of deliberate self-harm, as detected by a validated depression scale, and reported similar numbers (n=21 in the intervention group and n=23 in the control group [37] vs n=2 in the intervention group and n=3 in the control group [35]) or fewer numbers (n=1 in the intervention group and n=2 in the control group) [41]. Four trials comparing ICBT to usual care reported cardiovascular outcomes.

Jing Jing Su, Rose Lin, Ladislav Batalik, Arkers Kwan Ching Wong, Sherry L Grace

J Med Internet Res 2025;27:e57368

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

A much smaller number of studies (n=6) examined the utility of VR in chronic pain populations including intensive pain rehabilitation (n=1) [112], chronic burn dressing (n=1) [113], chronic musculoskeletal pain (n=1) [114], chronic cancer-related pain (n=2) [115,116], and chronic abdominal pain (n=1) [117]. See Figure 2 for the summary of pain populations included across the studies.

Courtney W Hess, Brittany N Rosenbloom, Giulia Mesaroli, Cristal Lopez, Nhat Ngo, Estreya Cohen, Carley Ouellette, Jeffrey I Gold, Deirdre Logan, Laura E Simons, Jennifer N Stinson

JMIR Pediatr Parent 2025;8:e63854

Impact of a 6-Week Postpartum Text Messaging Program (Essential Coaching for Every Mother) at 6 Months: Follow-Up Study to a Randomized Controlled Trial

Impact of a 6-Week Postpartum Text Messaging Program (Essential Coaching for Every Mother) at 6 Months: Follow-Up Study to a Randomized Controlled Trial

Comparison of high and low scores at 6 months postpartum by allocation. a Intervention (n=69) and control (n=70). b Intervention (n=68) and control (n=68). Based on 136 mothers who completed the postpartum anxiety measure at 6 months postpartum, there was no statistically significant difference in postpartum anxiety scores at 6 months postpartum (F1,131=1.077, P=.30, partial η2=0.00) (Table 2).

Justine Dol, Marsha Campbell-Yeo, Megan Aston, Douglas McMillan, Amy K Grant

JMIR Pediatr Parent 2025;8:e62841

Impact of a Symptom Checker App on Patient-Physician Interaction Among Self-Referred Walk-In Patients in the Emergency Department: Multicenter, Parallel-Group, Randomized, Controlled Trial

Impact of a Symptom Checker App on Patient-Physician Interaction Among Self-Referred Walk-In Patients in the Emergency Department: Multicenter, Parallel-Group, Randomized, Controlled Trial

Two eligible participants in the control group dropped out immediately after randomization—due to organizational issues (n=1) and a medical condition (n=1). Three participants assigned to the intervention group withdrew their consent, and 5 additional participants were lost due to organizational issues. Of the 434 included participants, 188 (43.3%) identified as male, 220 (50.7%) as female, and 4 (0.9%) as diverse (with 22 participants not indicating their sex). The median age was 33 (IQR 26-45) years.

Malte L Schmieding, Marvin Kopka, Myrto Bolanaki, Hendrik Napierala, Maria B Altendorf, Doreen Kuschick, Sophie K Piper, Lennart Scatturin, Konrad Schmidt, Claudia Schorr, Alica Thissen, Cornelia Wäscher, Christoph Heintze, Martin Möckel, Felix Balzer, Anna Slagman

J Med Internet Res 2025;27:e64028

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

We have randomized 22 administrative wards in a 1:1 ratio and aim to enroll about 72 adolescent girls and young women from each (total N=about 1584) to receive either the Tu’Washindi intervention plus usual HIV prevention services, or usual HIV prevention services alone.

Sarah T Roberts, Alexandra M Minnis, Sue Napierala, Elizabeth T Montgomery, Lina Digolo, Mackenzie L Cottrell, Erica N Browne, Jacqueline Ndirangu, Joyce Boke, Kawango Agot

JMIR Res Protoc 2025;14:e55931

Employers’ Perspectives of Caregiver-Friendly Workplace Policies for Caregiver-Employees Caring for Older Adults in Hong Kong: Thematic Analysis

Employers’ Perspectives of Caregiver-Friendly Workplace Policies for Caregiver-Employees Caring for Older Adults in Hong Kong: Thematic Analysis

The discussion guide was developed based on a thorough literature review, the first author’s previous Master’s thesis [35], and the opinions of 2 expert panels of researchers specializing in the field of caregiving (Professor E Wong, Professor D Dong, and Dr C Chan from the School of Public Health and Primary Care, The Chinese University of Hong Kong).

Maggie Man-Sin Lee, Eng-Kiong Yeoh, Eliza Lai-Yi Wong

JMIR Aging 2025;8:e68061