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Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

(D) IUH: negative 5-Cog result. At both sites, a paper token (Figure 4) is used as an additional feature to help ensure that care providers review the patients’ 5-Cog results. Patients are handed this token after they complete the 5-Cog battery and are asked to hand it to their care provider at their scheduled visit, generally within 30 minutes after the 5-Cog battery administration. Token to alert care provider for patient's 5-Cog participation.

Rachel Beth Rosansky Chalmer, Emmeline Ayers, Erica F Weiss, Nicole R Fowler, Andrew Telzak, Diana Summanwar, Jessica Zwerling, Cuiling Wang, Huiping Xu, Richard J Holden, Kevin Fiori, Dustin D French, Celeste Nsubayi, Asif Ansari, Paul Dexter, Anna Higbie, Pratibha Yadav, James M Walker, Harrshavasan Congivaram, Dristi Adhikari, Mairim Melecio-Vazquez, Malaz Boustani, Joe Verghese

JMIR Res Protoc 2025;14:e60471

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study

Indeed, a meta-analysis of VR-assisted exposure therapy for anxiety disorders showed a large overall effect size for VR exposure therapy compared with (mostly waitlist) control conditions (Cohen d=1.11, SE 0.15, 95% CI 0.82-1.39) [28]. Furthermore, research on the use of VR for psychosis treatment has indicated the approach can be feasible, acceptable, and effective for improving some symptoms including positive symptoms such as paranoia and hallucinations [29].

Jessica Spark, Elise Rowe, Mario Alvarez-Jimenez, Imogen Bell, Linda Byrne, Ilvana Dzafic, Carli Ellinghaus, Suzie Lavoie, Jarrad Lum, Brooke McLean, Neil Thomas, Andrew Thompson, Greg Wadley, Thomas Whitford, Stephen Wood, Hok Pan Yuen, Barnaby Nelson

JMIR Res Protoc 2025;14:e63405