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Optimizing Initial Vancomycin Dosing in Hospitalized Patients Using Machine Learning Approach for Enhanced Therapeutic Outcomes: Algorithm Development and Validation Study

Optimizing Initial Vancomycin Dosing in Hospitalized Patients Using Machine Learning Approach for Enhanced Therapeutic Outcomes: Algorithm Development and Validation Study

In the calibration plot of each algorithm, the lower the sum of the absolute value of the difference between the algorithm’s predicted probability and the observed true predicted probability corresponding to each bin midpoint, the better the algorithm was considered to be with fewer under or overestimates. To ensure the robustness and reliability of our results, we conducted a resampling procedure.

Heonyi Lee, Yi-Jun Kim, Jin-Hong Kim, Soo-Kyung Kim, Tae-Dong Jeong

J Med Internet Res 2025;27:e63983