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Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Similarly, Akinci et al [33] reported that in a small cohort (n=164), prepregnancy obesity, greater gestational weight gain, and a fasting glucose level (>5.5 mmol/L) on the 75-g OGTT predicted the development of metabolic syndrome in postpartum women with moderate to high discrimination. There are very few studies that use maternal characteristics to predict both maternal and fetal/neonatal pregnancy outcomes, even though they are inextricably linked.

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot Study

Co-Designing a Web-Based and Tablet App to Evaluate Clinical Outcomes of Early Psychosis Service Users in a Learning Health Care Network: User-Centered Design Workshop and Pilot Study

The institutional review board of the University of California, Davis, approved the study (1403828-21, California Collaborative Network to Promote Data-Driven Care and Improve Outcomes in Early Psychosis). In addition, several of the counties and universities with a program participating in EPI-CAL required a separate review and approval of the project by their institutional review board. All study participants provided written informed consent and assent (as appropriate).

Kathleen E Burch, Valerie L Tryon, Katherine M Pierce, Laura M Tully, Sabrina Ereshefsky, Mark Savill, Leigh Smith, Adam B Wilcox, Christopher Komei Hakusui, Viviana E Padilla, Amanda P McNamara, Merissa Kado-Walton, Andrew J Padovani, Chelyah Miller, Madison J Miles, Nitasha Sharma, Khanh Linh H Nguyen, Yi Zhang, Tara A Niendam

JMIR Hum Factors 2025;12:e65889

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

Examining Weight Suppression, Leptin Levels, Glucagon-Like Peptide 1 Response, and Reward-Related Constructs in Severity and Maintenance of Bulimic Syndromes: Protocol and Sample Characteristics for a Cross-Sectional and Longitudinal Study

GLP-1 is released by L cells in the intestine, and research in rats suggested that leptin potently stimulated postprandial GLP-1 release via leptin receptors on intestinal L cells [31,32]. Thus, our model posits that lower leptin level is associated with blunted postprandial GLP-1 response. Supporting this prediction, individuals with higher leptin levels have demonstrated more robust GLP-1 responses to food intake [33].

Pamela K Keel, Lindsay P Bodell, Sarrah I Ali, Austin Starkey, Jenna Trotta, J Woody Luxama, Chloé Halfhide, Naomi G Hill, Jonathan Appelbaum, Diana L Williams

JMIR Res Protoc 2025;14:e66554