This paper is in the following e-collection/theme issue:

Information Retrieval (287) Knowledge Translation and Implementation Science (398) Dental Sciences (119) Safety and Error Prevention in Health (202)

Published on in Vol 22, No 4 (2020): April

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/15304, first published .
Using Nonexpert Online Reports to Enhance Expert Knowledge About Causes of Death in Dental Offices Reported in Scientific Publications: Qualitative and Quantitative Content Analysis and Search Engine Analysis

Using Nonexpert Online Reports to Enhance Expert Knowledge About Causes of Death in Dental Offices Reported in Scientific Publications: Qualitative and Quantitative Content Analysis and Search Engine Analysis

Using Nonexpert Online Reports to Enhance Expert Knowledge About Causes of Death in Dental Offices Reported in Scientific Publications: Qualitative and Quantitative Content Analysis and Search Engine Analysis

Authors of this article:

Meike Gaiser1 Author Orcid Image ;   Joachim Kirsch1 Author Orcid Image ;   Till Sebastian Mutzbauer1, 2 Author Orcid Image
Article Authors Cited by (4) Tweetations (3) Metrics

    Original Paper

    1Institute for Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany

    2Maxillofacial Surgery and Dental Anesthesiology, Mutzbauer & Partner, Zürich, Switzerland

    *all authors contributed equally

    Corresponding Author:

    Till Sebastian Mutzbauer, MD, DDS

    Maxillofacial Surgery and Dental Anesthesiology

    Mutzbauer & Partner

    Tiefenhoefe 11

    Zürich, 8001

    Switzerland

    Phone: 41 44211 ext 1465

    Email: tsmutzbauer@gmail.com


    Background: Fatalities rarely occur in dental offices. Implications for clinicians may be deduced from scientific publications and internet reports about deaths in dental offices.

    Objective: Data involving deaths in dental facilities were analyzed using Google as well as the PubMed database. By comparing both sources, we examined how internet data may enhance knowledge about deaths in dental offices obtained from scientific medical publications, which causes of death are published online, and how associated life-threatening emergencies may be prevented.

    Methods: To retrieve relevant information, we searched Google for country-specific incidents of death in dental practices using the following keywords: “death at the dentist,” “death in dental practice,” and “dying at the dentist.” For PubMed searches, the following keywords were used: “dentistry and mortality,” “death and dental treatment,” “dentistry and fatal outcome,” and “death and dentistry.” Deaths associated with dental treatment in a dental facility, attributable causes of death, and documented ages of the deceased were included in our analysis. Deaths occurring in maxillofacial surgery or pre-existing diseases involved in the death (eg, cancer and abscesses) were excluded. A total of 128 cases from online publications and 71 cases from PubMed publications that met the inclusion criteria were analyzed using chi-square statistics after exclusion of duplicates.

    Results: The comparison between the fatalities from internet (n=117) and PubMed (n=71) publications revealed that more casualties affecting minors appeared online than in PubMed literature (online 68/117, 58.1%; PubMed 20/71, 28%; P<.001). In PubMed articles, 10 fatalities in patients older than 70 years of age were described, while online sources published 5 fatalities (P=.02). Most deaths, both from internet publications and PubMed literature, could be assigned to the category anesthesia, medication, or sedation (online 80/117, 68.4%; PubMed 25/71, 35%; P<.001). Deaths assigned to the categories infection and cardiovascular system appeared more often in the PubMed literature (infection: online 10/117, 8.5%; PubMed 15/71, 21%; P=.01; cardiovascular system: online 5/117, 4.3%; PubMed 15/71, 21%; P<.001). Furthermore, sedative drugs were involved in a larger proportion of fatal incidents listed online compared to in PubMed (online 41/117, 35.0%; PubMed: 14/71, 20%, P=.03). In the United States, more deaths occurred under sedation (44/96, 46%) compared to those in the other countries (Germany and Austria 1/17, 6%, P=.002; United Kingdom 1/14, 7%, P=.006).

    Conclusions: Online and PubMed databases may increase awareness of life-threatening risks for patients during dental treatment. Negative aspects of anesthesia and sedation, as well as the number of deaths of young patients, were underestimated when reviewing PubMed literature only. Medical history of patients, medication dosages, and vital function monitoring are significant issues for practitioners. A high-impact finding from online reports was the underestimation of risks when performing sedation and even general anesthesia. Detailed knowledge of the definition and understanding of deep sedation and general anesthesia by dentists is of major concern. By avoiding potentially hazardous procedures, such as sedation-aided treatments performed solely by dentists, the risk of treatment-induced life-threatening emergencies may be reduced.

    J Med Internet Res 2020;22(4):e15304

    doi:10.2196/15304

    Keywords

    dental death; dental practice; dental sedation; risk; internet search engine 


    Fortunately, complications with a fatal outcome rarely occur in dental offices. In the United Kingdom, for example, one dental-related death occurs per 464-758 dentist years [1]. Fatalities may occur not only in elderly and multimorbid patients but also in younger patients, especially in connection to more extensive surgical procedures [2]. The probability that one will experience a medical emergency in a dental setting is remarkably higher; in the United Kingdom, 9 to 11 emergencies occur over a period of 40 years as a dentist [1]. In Saxony, Germany, a study was conducted to find out how often medical emergencies occur in the practice of dentistry; more than 50% of the respondents reported 1 to 3 medical emergencies having occurred within a year and 36% reported the occurrence of up to 10 emergencies [3]. However, it is not possible to determine the fatality risk of life-threatening emergencies happening in dental facilities.

    Furthermore, it cannot be determined if fatalities occurred coincidentally or if the dentists’ treatments contributed to the fatal events. Despite the low incidence of fatalities in dental facilities, it is important to analyze the causes of death in order to gain knowledge about how these life-threatening emergencies could be prevented. Publications in scientific medical journals may contribute to awareness about medical emergencies occurring in dental facilities. However, it is assumed that additional information could be extracted from internet reports, which could enhance the knowledge about the background and pathogenesis of fatal events. Additional management strategies could be developed when considering information being published on the internet about medical emergencies having resulted in deaths. At best, dentists would avoid pursuing a life-threatening course of treatment, for example, by not performing interventions defined as at-risk procedures.

    In 2017, Reuter et al [4] performed a systematic review examining deaths that were related to dental procedures. They reviewed various specialized literature libraries without date restrictions and extracted data from North America, Europe, Asia, and South America about causes and affected patients. A total of 148 fatalities, with an average patient age of 34.6 years, were investigated. In scientific medical literature, as well as on the internet, deaths in dental facilities associated with sedation or general anesthesia have been reported; however, other causes have also been reported [4-32].

    The Google Trends database can display the search volume of a keyword, for instance, “dental.” Some differences in search volumes can be found for the keywords “dental” and “death” when comparing searches of these words in relation to the total counts of global searches using this database in the United States, the United Kingdom, and in German-speaking countries. However, because of a lack of data, probably due to a low number of searches, there are no statistics available regarding the search term “death dental office” in these respective countries. The term “dental” is searched for twice as often as the term “death” in the United States, the United Kingdom, and in Switzerland; in Germany and Austria, the term “death” is searched for even more seldomly in relation to the term “dental” (see Multimedia Appendix 1).

    The importance of the internet in daily life is increasing. Patients use the internet not only to obtain information but also to exchange experiences and to rate doctors. In a study from 2017, it was demonstrated that the number of doctor ratings were increasing [5]. For clinicians, the internet offers additional resources and scientific insights into problems and trends that might be helpful in their daily work as well as for the prevention of diseases. Forums, for example, may deal with patient fears and could be helpful for clinicians as well; they may benefit from patients’ and laypersons’ points of view and adjust their treatments accordingly.

    To the best of our knowledge, there is no overview of deaths in dental offices that has been published on the internet. Hence, we performed a qualitative and quantitative analysis of online publications and medical literature covering fatalities in dental offices in German-speaking countries, France, the United Kingdom, and the United States. In addition to the causes of death, patient groups were analyzed.

    This study aims to examine content regarding death in dental treatment facilities that has been published on the internet and retrieved by the Google search engine and compare these findings with content extracted from the scientific medical literature.

    The specific research topics of the study are as follows:

    1. Which causes of death in dental offices are published on the internet?
    2. How can the internet as a database enhance knowledge from scientific medical publications regarding deaths in dental offices?
    3. What implications for clinicians can be deduced from internet reports and scientific publications about the reasons for deaths in dental offices?

    Searches Using the Google Search Engine

    Between December 21, 2016, and May 3, 2017, we performed a country-specific Google search for deaths in dental facilities. For the German language, where we used the URL top-level domains .de, .at, and .ch, German equivalents of the keywords “death at the dentist,” “death in dental practice,” and “dying at the dentist” were used. The terms “death at dentist,” “death in dental office,” and “dying at the dentist” were used for the English language, where the URL top-level domains .uk and .com were used. The term “death at dentist” was searched in the French language, where the URL top-level domain .fr was used.

    An article related to a fatality was included when it had not been published in a medical specialist journal. Additionally, internet pages containing a collection of deaths in a dentist´s or a physician´s office were included. The internet was additionally searched for related content on May 31, 2018, and on October 31, 2018.

    Selection of Websites

    Articles were included if a patient´s death had been associated with a dental treatment in a dental facility. Furthermore, the age of the casualty and the cause of death had to be indicated, as well as information about the type of anesthesia if the fatality was anesthesia related. In case of a severe pre-existing disease related to the oral cavity (eg, existing abscesses, infections, or tumor diseases), the case was excluded. Deaths related to oral and maxillofacial surgery were also excluded.

    Systematization of Articles Found Using Google

    The systematization regarding the use of anesthesia was done as follows. Anesthesia was assigned to the category general anesthesia when “general anesthesia” or an intubation had been mentioned or when only the term “anesthesia” had been used by the author, even if local anesthesia had been used additionally. The category sedation was chosen when the terms “sedation,” “sedating drugs,” “sedate,” “tranquilization,” or “nitrous oxide” had been used.

    Where there was a lack of information regarding anesthesia, an article only qualified for inclusion if the type of anesthesia had had no influence on the death or the information was unnecessary for the allocation of the cause of death. Cases with general anesthesia or sedation were evaluated with relation to the presence of an anesthesiologist. Furthermore, the anesthesia used was examined with relation to the administration of nitrous oxide. Table 1 lists the categories of the causes of death.

    The patients were divided into the following age groups: 0-5 years, 6-17 years, 18-30 years, 31-55 years, 56-70 years, and >70 years. Imprecise age information was rounded; for instance, early 30s was rounded to 32 and mid-70s to 75.

    Table 1. Categories of causes of death.
    CategoriesExamples
    Anesthesia, medication, or sedationOverdose, anaphylaxis, hypoxia, interactions, or any other recognizable cause
    Airway or respiratory systemSuffocation, aspiration, false intubation, or laryngeal edema
    Bleeding or coagulationHigh blood loss, bleeding, or disseminated intravascular coagulation
    Cardiovascular systemHeart attack, cardiac arrest, aneurysm, or air embolism
    InfectionBacterial, viral, or fungal infection; endocarditis, pneumonia, fasciitis, or mucormycosis
    OthersCausative, but not temporary; temporary, but not causative

    Searches in PubMed

    On May 11, 2017, a systematic literature search was performed in PubMed. We searched for the following Medical Subject Headings keywords: Dentistry AND Mortality OR Death AND Dental Treatment OR Dentistry AND Fatal Outcome OR Death AND Dentistry. Through filters, the search was limited to a period of the last 30 years and the term “humans.” PubMed was additionally searched on May 31, 2018, and on October 31, 2018.

    Selection and Systematization of Relevant Articles From PubMed

    The inclusion criteria described in the above sections applied to online literature as well. Editorials, letters, and duplicates were excluded. Articles from Europe, North America, and Australia were included. The systematization was completed analogously to the online database.

    Comparison of Selected Publications by Chi-Square Statistics

    Eventually, all included deaths from online publications were summarized and compared to the included deaths found in PubMed publications. After carefully reviewing all the cases, duplicates or possible duplicates were excluded before the evaluation of the results using chi-square statistics; the statistical software XLSTAT, version 2018 (Addinsoft), was used for analysis. For further statistical analysis and to definitively exclude duplicate cases, the deaths were assessed by year of occurrence and additionally divided into two groups: cases that occurred before 1995 and cases that occurred after 1994.


    Online Publications

    Online Results in Total

    A total of 18 casualties were found in Germany and 2 were found in Austria. Groups of deaths in the two countries were summarized as deaths in German-speaking countries. In Switzerland, no deaths were reported on the internet. A total of 120 deaths were reported from the United States, 15 from the United Kingdom, and 1 from France. After excluding 28 cases, there were a total of 128 casualties reported from online publications (see Figure 1).

    Online Results for Germany and Austria

    A total of 3 casualties were excluded from the 20 found in Germany and Austria. The mean age of the 17 remaining casualties was 19.3 years (SD 21.9; median 10 years). The dominating age group was 0-5 years and included 8 fatalities (8/17, 47%). A total of 2 of the deceased (2/17, 12%) were in the 6-17-year age group, whereas the age groups 18-30 years and 31-55 years had 3 patients in each (3/17, 18%). Of the 17 deceased, 1 (6%) was older than 70 years of age and the age group 56-70 years was not represented. A total of 11 patients out of 17 were female (65%) and 6 were male (35%).

    The most common cause of death could be attributed to the category anesthesia, medication, or sedation (14/17, 82%), followed by bleeding or coagulation (2/17, 12%) and infection (1/17, 6%). For a breakdown of the number of casualties due to anesthesia, medication, or sedation by age, see Multimedia Appendix 2.

    Prior to their death, 13 out of 17 casualties (76%) had been treated under general anesthesia. In 1 case each out of 17 (6%), sedation or local anesthesia had been administered, and in 2 cases (12%) no details were given.

    ‎
    Figure 1. Flowchart for article selection from Google results on the basis of article title. UK: United Kingdom; US: United States.
    View this figure
    Online Results for the United Kingdom

    The mean age of the 14 deceased patients was 30.5 years (SD 22.1; median 28.5 years). The dominating age groups were 6-17 years and 31-55 years, with 4 cases out of 14 (29%) each, whereas 2 patients (14%) in the age group 0-5 years died. The age group 18-30 years was represented with 1 case out of 14 (7%). Of the 14 deceased, 3 (21%) were in the 56-70-year age group, and the over-70-year age group was not affected at all. Half of the deceased were male (7/14, 50%) and half were female (7/14, 50%).

    In the United Kingdom, the cause of death was attributed to the anesthesia, medication, or sedation category in 9 of the 14 cases (64%), to bleeding or coagulation in 3 cases (21%), and to infection and others in 1 (7%) case each. In the others category, a case of a small girl who had been starving to death after a traumatic visit to the dentist was described. For a breakdown of the number of deaths due to anesthesia, medication, or sedation by age, see Multimedia Appendix 3.

    General anesthesia had been administered in 6 of the 14 cases (43%), sedation in 1 case (7%), and local anesthesia in 5 cases (36%). In addition, 2 patients (14%) did not receive any anesthesia at all.

    Online Results for the United States

    The mean age of the deceased patients was 22.6 years (SD 21.6; median 17 years). More than every second deceased patient was a minor: 25 out of 96 (26%) were in the 0-5-year age group, 29 (30%) were in the 6-17-year age group, 18 (19%) were in the 18-30-year age group, and 12 (13%) were in the 31-55-year age group. In the age group 56-70 years, 7 patients (7%) died, and 5 (5%) of the deceased were older than 70 years. Out of 96 deceased patients, 54 (56%) were male and 42 (44%) were female.

    In the United States, 61 of 96 casualties (64%) were assigned to the anesthesia, medication, or sedation category. Out of 96 cases, 51 (53%) were related to anesthesia (ie, general anesthesia, sedation, or local anesthesia) and the other 10 cases (10%) were attributed to medication given before or after treatment (eg, pain medication and antibiotics). For a breakdown of the number of deaths due to anesthesia, medication, or sedation by age, see Multimedia Appendix 4. A total of 15 out of 96 (16%) deaths were assigned to the airway or respiratory system category, 8 cases (8%) to the cardiovascular system, 9 (9%) to infection, and 2 (2%) to others, which included 1 that was defined as a “natural cause of death” and 1 (1%) that was attributed to an asthma attack. Out of 96 cases, 1 (1%) was assigned to the bleeding or coagulation category.

    In 29 out of 96 cases (30%), no information about the administered anesthesia had been reported. Most of the casualties had undergone sedation (44/96, 46%), and 16 patients (17%) had been treated under general anesthesia. In 7 cases (7%), only local anesthesia had been used.

    From the United States, papers including 11 cases that had received nitrous oxide had been published. In 10 of these cases, the cause of death was assigned to anesthesia, medication, or sedation; these are subdivided in Table 2.

    Table 2. Dental practice casualties involving nitrous oxide assigned to the anesthesia, medication, or sedation category from online publications in the United States.
    Sedative agentsCasualties (n=10), n (%)
    Nitrous oxide with local anesthesia

    		Total3 (30)

    		Nitrous oxide reported to be causative1 (10)
    Nitrous oxide with sedative drugs or general anesthesia

    		Total7 (70)

    		Nitrous oxide reported to be causative2 (20)

    In the 11th case where nitrous oxide was used, the cause of death was assigned to the airway or respiratory system category. This case had also been reported in the PubMed literature; the little girl had died after having aspirated a cotton roll. In only 1 of the 11 cases (9%), an anesthesiologist had been on site, and in 1 case (9%) there was no information regarding an anesthesiologist standing by.

    In Table 3, all fatalities under general anesthesia and sedation were listed regarding the presence of an anesthesiologist or anesthetist. In the cases without a supervising anesthesiologist, a second dentist or even the treating dentist himself or herself had acted as anesthesiologist. It is unclear whether the respective dentists had completed an advanced training course prior to the procedures.

    Table 3. Fatalities in dental practices under general anesthesia and sedation with respect to the presence of an anesthesiologist or anesthetist, based on data from online publications in the United States.
    Setting of fatalitiesAnesthesiologist present, n (%)Anesthetist present, n (%)No anesthesiologist or anesthetist present, n (%)No information, n (%)
    Fatalities where general anesthesia or sedation were used (n=60)6 (10)1 (2)33 (55)20 (33)
    Fatalities where general anesthesia or sedation were used and cause of death was assigned to anesthesia, medication, or sedation category (n=47)6 (13)1 (2)26 (55)14 (30)
    Online Results for France

    Only 1 casualty occurred in France. The deceased was a 7-year-old boy who had aspirated a protective cover for the x-ray film and had suffocated in the dental office. Consequently, the death was classified as airway or respiratory system. No anesthesia had been administered to the patient.

    PubMed Publications

    PubMed Publications in Total

    We found 886 publications from our PubMed search. The flowchart in Figure 2 describes the process of exclusion and inclusion of publications. A total of 733 publications were excluded based on the title, 95 were excluded based on the abstract, and 58 publications underwent a full-text review. Finally, 37 publications reporting a total of 71 fatalities were included in the study. A total of 20 publications were case reports [9,10,12,13,18,20,22,24-26,28-37], 5 were retrospective studies [6,14,21], and 12 were case studies [7,8,11,17,19,23,26,38-42].

    ‎
    Figure 2. Flowchart for article selection from PubMed results.
    View this figure
    PubMed Results

    The mean age of the 71 deceased from the PubMed literature was 37.9 years (SD 26.4; median 32 years) and included 43 (61%) male and 27 (38%) female patients. In 1 case (1%), the author had not specified a gender. The dominating age groups were 56-70 years and minors up to 5 years of age, with 15 cases (21%) each. The age group between 6 and 17 years was represented by 5 cases (7%), and the age group between 18 and 30 years was represented by 14 cases (20%). Of the 71 deceased, 12 (17%) died between 31 and 55 years of age and 10 (14%) were older than 70 years of age.

    According to the PubMed literature, 25 cases out of 71 (35%) were assigned to the anesthesia, medication, or sedation category. A total of 24 cases (34%) were related to anesthesia (ie, general anesthesia, sedation, or local anesthesia), while the 25th patient died due to an anaphylactic shock originating from the dental impression material. The infection and the cardiovascular system categories were represented by 15 cases (21%) each, the airway or respiratory system category by 12 cases (17%), and the bleeding or coagulation category by 4 cases (6%). For a breakdown of the number of deaths due to anesthesia, medication, or sedation by age, see Multimedia Appendix 5.

    The most common cause of death was from general anesthesia (22/71, 31%), followed by local anesthesia and sedation with 14 cases each (20%). Only 1 casualty (1%) had occurred completely without anesthesia. In the remaining 20 cases (28%), the author had not provided any information about the anesthesia administered.

    Out of 71 fatalities, the 36 cases (51%) where general anesthesia or sedation had been used were examined with respect to the presence of an anesthesiologist or anesthetist (see Table 4).

    Table 4. Fatalities in dental practices with general anesthesia and sedation with respect to the presence of an anesthesiologist or anesthetist, based on data from PubMed publications.
    Setting of fatalitiesAnesthesiologist present, n (%)Anesthetist present, n (%)No anesthesiologist or anesthetist present, n (%)No information, n (%)
    Fatalities where general anesthesia or sedation were used (n=36)3 (8)6 (17)5 (14)22 (61)
    Fatalities where general anesthesia or sedation were used and cause of death was assigned to anesthesia, medication, or sedation category (n=19)3 (16)2 (10)4 (21)10 (53)

    In PubMed, 11 fatalities where nitrous oxide had been used were described. In 8 of these cases (73%), the cause of death was classified as anesthesia, medication, or sedation. However, it was not obvious that nitrous oxide was the cause of death in any of the cases; only the involvement of nitrous oxide was mentioned. The other 3 cases (27%) involving nitrous oxide were assigned to the airway or respiratory system category. Those patients had died because of aspiration of a cotton roll, bronchospasm, or laryngeal edema. In Table 5, the PubMed data are compared with online results.

    Table 5. Age and sex of casualties, cause of death, and anesthesia used in dental facilities found in online publications from three country groups compared with the PubMed literature.
    VariableGermany and Austria
    (n=17), n (%)    		United Kingdom
    (n=14), n (%)    		United States
    (n=96), n (%)    		PubMed
    (N=71), n (%)
    Age (years)




    		0-58 (47)2 (14)25 (26)15 (21)

    		6-172 (12)4 (29)29 (30)5 (7)

    		18-303 (18)1 (7)18 (19)14 (20)

    		31-553 (18)4 (29)12 (13)12 (17)

    		56-700 (0)3 (21)7 (7)15 (21)

    		>701 (6)0 (0)5 (5)10 (14)
    Sex




    		Female11 (65)7 (50)42 (44)27 (38)

    		Male6 (35)7 (50)54 (56)43 (61)

    		Not specified0 (0)0 (0)0 (0)1 (1)
    Cause of death




    		Anesthesia, medication, or sedation14 (82)9 (64)61 (64)25 (35)

    		Bleeding or coagulation2 (12)3 (21)1 (1)4 (6)

    		Infection1 (6)1 (7)9 (9)15 (21)

    		Others0 (0)1 (7)2 (2)0 (0)

    		Cardiovascular system0 (0)0 (0)8 (8)15 (21)

    		Airway or respiratory system0 (0)0 (0)15 (16)12 (17)
    Anesthesia




    		General anesthesia13 (76)6 (43)16 (17)22 (31)

    		Sedation1 (6)1 (7)44 (46)14 (20)

    		Local anesthesia1 (6)5 (36)7 (7)14 (20)

    		None0 (0)2 (14)0 (0)1 (1)

    		No information2 (12)0 (0)29 (30)20 (28)

    Comparison of PubMed Literature With Summarized Online Publications

    Age

    The mean age of the deceased patients in online publications was 22.9 years (SD 21.6; median 17 years) compared with 37.9 years (SD 26.4; median 32 years) in PubMed articles. For a compilation of the age distribution, see Multimedia Appendix 6.

    Cause of Death

    The anesthesia, medication, or sedation category dominated the online and the PubMed publications (see Table 5); however, the proportions in PubMed were only about half as high compared to online publications. Whereas bleeding or coagulation problems did not show a large difference, infection, cardiovascular system, and airway or respiratory system problems were overly represented in PubMed (see Figure 3).

    ‎
    Figure 3. Percentage of casualties for each cause of death in dental facilities using data from online publications and PubMed. Possible duplicates were not excluded. A/M/S: anesthesia, medication, or sedation; B/C: bleeding or coagulation; I: infection; O: others; Ca: cardiovascular system; Aw/R: airway or respiratory system.
    View this figure
    Anesthesia

    Whereas local anesthesia as the reason for fatal incidents showed a higher proportion in PubMed publications, sedation was more strongly represented in online reports. No large differences in general anesthesia fatality rates were found. For a breakdown of the types of anesthesia used, see Multimedia Appendix 7.

    Anesthesia and Age

    The analysis of PubMed articles showed higher proportions of both sedation and local anesthesia leading to fatalities among patients 5 years of age and younger compared to online publications. However, the proportion of sedation leading to fatalities dominated the 6-17-year-old and 31-years-and-older age groups in online media. General anesthesia showed higher percentages in online publications among the 6-17-year-old and 56-70-year-old age groups and higher percentages in PubMed articles among the 18-30-year-old and 31-55-year-old age groups (see Figure 4).

    ‎
    Figure 4. Percentage of deaths in dental facilities reported in online and PubMed publications categorized as anesthesia, medication, or sedation with the use of general anesthesia (GA), sedation (Sed), or local anesthesia (LA) in each age group (years, y). Possible duplicates were not excluded.
    View this figure

    Comparison by Chi-Square Statistics

    Selection of Publications to Compare

    Out of 128 deaths found in online publications, 11 cases (8.6%) were excluded for statistical analysis, as these were also found in the PubMed literature. Therefore, 117 cases from online publications were compared with 71 cases from the PubMed literature using chi-square statistics. When comparing the three country groups—Germany and Austria, the United Kingdom, and the United States—all cases were included.

    Age

    A higher proportion of fatalities in the 17-years-and-younger age group was found in online publications (68/117, 58.1%) compared to PubMed articles (20/71, 28%). However, among the group of patients older than 70 years, fatal outcomes were found in 14% (10/71) of PubMed publications compared to 4.3% (5/117) of online publications (see Table 6).

    Table 6. Comparison of fatalities reported in online and PubMed publications with respect to the age of deceased patients.
    Patient age groupNumber of fatalities, n (%)P value

    		Online (N=117)PubMed (N=71)
    Over and under 18 years

    		<.001

    		<18 years68 (58.1)20 (28)

    		≥18 years49 (41.9)51 (72)
    Over and under 70 years

    		.02

    		≤70 years112 (95.7)61 (86)

    		>70 years5 (4.3)10 (14)
    Causes of Death

    Fatalities in the anesthesia, medication, or sedation category dominated online, whereas infection and cardiovascular system rates were higher in PubMed. No differences between online and PubMed publications were found when airway or respiratory system and bleeding or coagulation categories were compared (see Table 7).

    Table 7. Comparison of fatalities reported in online and PubMed publications with respect to causes of death.
    Cause of deathNumber of fatalities, n (%)P value

    		Online (N=117)PubMed (N=71)
    Anesthesia, medication, or sedation

    		<.001

    		Yes80 (68.4)25 (35)

    		No37 (31.6)46 (65)
    Infection

    		.01

    		Yes10 (8.5)15 (21)

    		No107 (91.5)56 (79)
    Cardiovascular system

    		<.001

    		Yes5 (4.3)15 (21)

    		No112 (95.7)56 (79)
    Airway or respiratory system

    		.26

    		Yes13 (11.1)12 (17)

    		No104 (88.9)59 (83)
    Bleeding or coagulation

    		.88

    		Yes6 (5.1)4 (6)

    		No111 (94.9)67 (94)

    Comparison Regarding the Use of Sedation

    The number of fatalities attributed to sedation were higher in online reports covering the US population compared to data from other countries (see Table 8). The proportion of sedation as the reason for fatal outcomes was higher in the online reports (41/117, 35.0%) compared to articles from PubMed (14/71, 20%) (see Table 9).

    Table 8. Comparison of fatalities in dental facilities as a result of sedation reported in online publications with respect to country.
    CountryFatalities resulting from sedation, n (%)Fatalities not resulting from sedation, n (%)P value
    Germany and Austria (n=17)1 (6)16 (94)N/Aa
    United Kingdom (n=14)1 (7)13 (93)N/A
    United States (n=96)44 (46)52 (54)N/A
    Germany and Austria vs United KingdomN/AN/A.89
    Germany and Austria vs United StatesN/AN/A.002
    United Kingdom vs United StatesN/AN/A.006

    aN/A: not applicable.

    Table 9. Comparison of fatalities in dental facilities as a result of sedation in online and PubMed publications.
    Publication sourceFatalities resulting from sedation, n (%)Fatalities not resulting from sedation, n (%)P value
    Online (N=117)41 (35.0)76 (65.0).03
    PubMed (N=71)14 (20)57 (80)

    Comparison Before 1995 and After 1994

    To fully exclude duplicates, the online cases after 1994 were compared with the PubMed cases before 1995. As shown in Table 10, there is no difference between the respective time frames regarding PubMed or when the numbers in the categories leading to fatalities were compared.

    Whereas data identifying anesthesia, medication, or sedation as contributing factors dominated in online reports after 1994 compared to publications listed in PubMed before 1995, sedation-related casualty proportions in both of the examined databases were not different (see Table 11).

    Table 10. Comparison of fatalities in dental facilities described in PubMed before 1995 and after 1994 with respect to deaths assigned to the anesthesia, medication, or sedation and sedation-only categories.
    Cause of deathFatalities reported in PubMed, n (%)P value

    		Before 1995 (n=23)After 1994 (n=48)
    Anesthesia, medication, or sedation

    		.63

    		Yes9 (39)16 (33)

    		No14 (61)32 (67)
    Sedation only

    		.77

    		Yes5 (22)9 (19)

    		No18 (78)39 (81)
    Table 11. Comparison of fatalities in dental facilities described in PubMed before 1995 and online after 1994 with respect to deaths assigned to the anesthesia, medication, or sedation and sedation-only categories.
    Cause of deathFatalities reported, n (%)P value

    		PubMed before 1995 (n=23)Online after 1994 (n=108)
    Anesthesia, medication, or sedation

    		.008

    		Yes9 (39)74 (68.5)

    		No14 (61)34 (31.5)
    Sedation only

    		.24

    		Yes5 (22)37 (34.3)

    		No18 (78)71 (65.7)

    Principal Findings and Implications

    Overview

    The main finding of this study was that reports regarding causes of death in dental offices published on the internet enhance knowledge about the respective fatalities compared to extracting data from PubMed only. Fatalities associated with medication, general anesthesia, and sedation would have been underrepresented if only examining fatalities published in PubMed without considering cases reported on the internet. The same applies to the fatality rates of minors having died related to a dental treatment. In comparison to Reuter et al [4], the PubMed literature review conducted in this study was restricted to the last 30 years and to publications from Europe, North America, and Australia. Therefore, a lower number of death cases were obtained in this study’s PubMed search. This procedure was applied in order to use the same criteria in both the PubMed and online searches and to enable a reasonable comparison of the results. Reuter et al’s publication [4], as well as this study, revealed a fatality value of 21% for the category cardiovascular system; in addition, as a main result, it can be concluded that in both works most fatalities were assigned to the category anesthesia, medication, or sedation.

    Age

    The differing mean age in online publications (mean 22.9 years, SD 21.6; median 17 years) and in the PubMed literature (mean 37.9 years, SD 26.4; median 32 years) can possibly be explained by an increased awareness by the public when younger people die as a result of dental treatment.

    On the other hand, the authors of the PubMed articles evaluated available data using a scientific approach. This may explain the higher average age in scientific literature as reflecting a more even age distribution.

    Cause of Death
    Overview

    Death categories in PubMed articles were more evenly distributed compared to online publications. In both the online publications and in the PubMed literature, the most common cause of death could be assigned to the anesthesia, medication, or sedation category; the percentage in online publications was 65.6% (84/128), which is almost twice as high as in the PubMed articles (25/71, 35%).

    Presumably, articles describing deaths associated with anesthesia or sedation (ie, anesthesia, medication, or sedation category) may induce a compassionate effect in a normal reader and are, therefore, more suitable for headlines, especially when the group of patients is under 18 years of age, which was overly represented.

    Furthermore, it is noticeable that only 11 out of 128 (8.6%) of the fatalities reported in online publications occurred after infection, whereas 21% (15/71) of infection-related fatalities were found in PubMed articles. This could be explained by symptoms of infection having developed with delay after dental treatment. Compared with a death directly related to the administration of anesthesia or sedation for dental treatment, delayed infection may be less suitable as an online headline.

    In addition, a clear difference between online publications (8/128, 6.0%) and PubMed articles (15/71, 21%) in the category cardiovascular system was found. This difference may have resulted from the higher average age of the patients in the PubMed articles. Furthermore, it is assumed that deaths in the cardiovascular system category were not associated with dental treatments, especially by medical laypersons.

    Anesthesia, Medication, or Sedation 

    In the case of deaths attributed to the category anesthesia, medication, or sedation, omissions in the use of adequate equipment or medication overdose had predominantly been responsible for the death of the patient. Furthermore, medication side effects or undiscovered diseases had sometimes been attributed to the fatal outcome. Regarding these causes of death, dentists’ adequate knowledge of the equipment, medication, and respective complications is rated as a major issue. Whether anesthesiologists have been underinformed or have been ignoring related health or safety issues in the respective cases remains unclear.

    Data from the 1960s until now already show an impact of anesthesia, medication, or sedation procedures on fatalities in dental facilities. However, some bias may arise regarding substances historically available that are no longer in use in many countries, such as halothane [4]. Enhanced knowledge about fatalities in dental facilities covering the last 30 years has been obtained from additional information derived from internet reports compared to PubMed literature alone within this time frame. Although some historical medication identified as a cause of death in previous publications is no longer available, performing sedation or even general anesthesia in certain dental facilities without the assistance of an anesthesiologist is still considered dangerous.

    Frequently, online publication analysis revealed that both dentists and dental staff had had no or insufficient knowledge of lifesaving procedural management. Regular emergency management and cardiopulmonary resuscitation training is advisable [43]. Emergency management of the respective complications would not be necessary if at-risk interventions, such as deep sedation or even general anesthesia, by dentists could be avoided, since these complications would not even occur. Dentists should probably be discouraged from performing these procedures. Awareness of the actual status of these procedures in the dental office as well as knowledge of the definition of deep sedation and general anesthesia may be of major concern.

    Bleeding or Coagulation

    Deaths attributed to the category bleeding or coagulation may have occurred because of underestimation of the bleeding risk. Although a coagulation disorder or the use of anticoagulants was known, surgical procedures had often been performed without consulting the patient’s physician or without using adequate hemostyptic medical devices. In online publications, cases had also been reported in which patients had not returned to the dental office despite recurrent bleeding and had then bled to death, for example, during sleep. It is quite possible that patients may underestimate a rebleeding episode and, therefore, avoid another consultation with the dentist. In particular, because of an increasing number of patients taking anticoagulant medication, the importance of an accurate survey of the patient’s history and consultation with the patient’s physician, as well as sufficient instructions for the patient after a surgical procedure, is highlighted [44]. Furthermore, an accurate assessment of a patient’s bleeding risk enables the dentist to be prepared for intra- or postoperative bleeding (eg, with topical hemostatic agents or mechanical techniques) [45].

    Other causes of death in this category are unknown diseases, for example, liver-related diseases, which may also influence the coagulation system. Unfortunately, these risks cannot be completely ruled out, even if the patient is carefully examined and the surgery performed properly.

    Infection

    In the PubMed literature, in particular, a considerable number of deaths that were categorized as infection and deaths because of endocarditis were described. While 7 cases were found in PubMed, only 1 case was reported in online publications, where a patient had died because of endocarditis. In 4 of these cases, it was stated that the treating dentist had not administered antibiotic prophylaxis before the treatment. In the other 3 cases, this information could not be clearly tracked from the publication. With an incidence of 3-7 cases per 100,000 people, infectious endocarditis is a rare but serious disease with a mortality rate of 20%-25% [46-50].

    Dentists need to be aware of the indications for administering antibiotic prophylaxis. The recommendations to administer antibiotic prophylaxis to patients at risk before dental treatment have recently undergone certain modifications [51]. To prevent infectious endocarditis, dentists should consult the patient’s physician or cardiologist when treatment of at-risk patients is planned.

    Cardiovascular System

    In both the online publications and the PubMed literature, deaths assigned to the cardiovascular system category were described. As reported earlier [4], in this study, cases were occasionally found in which a relationship to the anesthesia or medication used could not be completely ruled out. Nevertheless, as in other categories, a detailed survey of the patient’s history is essential and, if necessary, a consultation with the patient’s physician or cardiologist would be recommended. A fatal cardiovascular incident can occur anywhere; in a dental office, a distinction is made between cases that would have occurred independently from dental treatment and cases triggered by the treatment (eg, stress and local anesthesia) [43]. Air embolism is a very rare complication but has been described during drilling procedures for dental implant placement. Therefore, air-operated handpieces are obsolete for this procedure, and the equipment recommended by the manufacturer of the implants should be used [52].

    Airway or Respiratory System

    In online publications, about half of the deaths in the airway or respiratory system category had been caused by aspiration of foreign bodies (eg, tooth, cotton roll, swabs, and instruments) or stomach contents. However, swelling (eg, abscess and hematoma) with airway occlusion, as well as 1 case of suffocation having resulted from the patient’s position during treatment, has been described as well. In the PubMed publications, mainly hereditary angioedema had been responsible for the described fatalities. As it can be triggered even by oral manipulation during dental treatment, a patient’s lack of knowledge even after having been informed about the diagnosis years ago may have contributed to the occurrence. Since the onset of swelling may be delayed more than 24 hours after a dental procedure, the dentist may not even be involved in emergency management. Therefore, a survey of the patient’s history should involve questions about these respective issues. In cases with a positive history, dental treatment should only be performed after consultation with the primary care physician [23,53].

    Aspiration of foreign bodies may be prevented using protective membranes, such as rubber dams, especially in endodontic treatments [54]. However, this does not protect against aspiration of extracted teeth, cotton rolls, or gauze positioned in the throat in cases of general anesthesia and endotracheal intubation.

    Anesthesia and Sedation
    Overview

    Anesthesia and sedation are considered priority topics in both this and other studies [4], therefore, they are discussed in more detail in this section. While the proportions of general anesthesia related to the respective deaths were almost equal in online publications (35/128, 27.3%) and in the PubMed literature (22/71, 31%), differences were noted in the use of sedation and local anesthetics. Under sedation, the percentage of deaths in online publications (46/128, 35.9%) was almost twice as high as those in the PubMed articles (14/71, 20%). Compared with general anesthesia, sedation of dental patients might be perceived as a harmless procedure.

    The primary concern of the authors of online publications had probably not been to draw attention to the underestimation of risks by dental sedation. However, the additional knowledge extracted from the internet reports in this study may contribute significantly to the awareness of these risks in the dental community.

    Local Anesthesia

    In online publications, 10.2% (13/128) of the described deaths had been attributed to local anesthetic treatment compared with 20% (14/71) in the PubMed literature. It is unclear whether the deaths caused by this type of anesthesia are underreported on the internet.

    The importance for including cases with supposedly less-harmful local anesthetic for the professional world is emphasized to draw attention to the risks and to define measures of care. It is noticeable that fatalities under local anesthesia in the PubMed articles covered mainly the group of children up to 5 years of age, where the dentists may have underestimated the risk of overdose.

    Sedation and General Anesthesia

    In online publications and in the PubMed literature, cases were described in which nitrous oxide had been used. In the specialist literature, however, no direct involvement of nitrous oxide in the death of the patients could be detected. In the fatalities described in online publications from the United States, nitrous oxide had been reported to be causative in 3 out of 10 cases (30%). A limitation could be the perception of the author of the respective internet post, who may have reported speculation as fact. In addition, a coroner’s report had not been cited.

    Nitrous oxide is still widely used in dentistry. In online publications, deaths involving nitrous oxide are reported exclusively from the United States. This may be due to the perception of maximum safety of nitrous oxide. In the last 30 years, the number of states where no further approval is needed for its administration has been decreasing [55].

    Only 1 sedation case could be retrieved online from Germany and Austria. Younger fatalities, especially below 5 years of age, had occurred under general anesthesia.

    As there were no respective fatality reports from online publications covering the United Kingdom, the German-speaking countries, as well as France, nitrous oxide involvement can only be analyzed from the US data. Nitrous oxide had contributed to the fatal course of treatment in only 10 cases. Because of the low number, no statement can be made about whether additional sedative or anesthetic drugs involved may have enhanced the medical problem leading to death. Only 1 fatality caused by foreign body aspiration in connection to nitrous oxide was published on the internet. However, as extracted from the PubMed database, the problem of aspiration and related issues, such as bronchospasm and laryngeal edema, seems to be more relevant during nitrous oxide use. This should increase the perception of the respective risk under adjunctive nitrous oxide or additional sedation during dental treatment under local anesthesia. It is expected that in most situations where nitrous oxide is used in dental treatment facilities the dentist has no additional anesthesiologist support. However, in the data obtained here, additional sedative medication had been used in 7 fatalities and in only 1 case an anesthesiologist was standing by.

    In Germany and Austria, the predominant adjunctive measures had been general anesthesia performed by a certified anesthesiologist, whereas sedation procedures or even general anesthesia had been performed without a certified anesthesiologist in a significant number of cases in the United States. Sedation-related problems leading to the death of a patient seem to be more relevant in the United States compared with the other areas examined (see Table 8).

    A significant association of deaths due to anesthesia or sedation with the presence or absence of an anesthesiologist has been demonstrated [4]. In more than 50% of fatalities reported in online publications covering the United States, where adjunctive general anesthesia or sedation had been used, it became obvious that no anesthesiologist had been on site during either general anesthesia or sedation. Our PubMed search found only 5 cases out of 36 (14%) where no anesthesiologist had been on site during adjunctive general anesthesia or sedation procedures. However, in 22 out of 36 cases (61%), no information about a specialist standing by had been provided. Nevertheless, this difference is remarkable, as the internet reports regarding this category almost exclusively cover the United States database. Even if an overlap between the internet and PubMed databases cannot fully be excluded, the high percentage in the internet reports may increase awareness among clinicians that the factor anesthesiologist on site is significantly influencing the course of respective incidents. This factor would have been underreported without the internet analysis.

    It is also remarkable that in more than one-third of deaths reported in the PubMed literature and in almost two-thirds of deaths found in the internet publications covering the United States and the United Kingdom, an anesthesia, medication, or sedation-related problem was at least partly involved in the fatal outcome (see Table 5). Data may focus the awareness of dental practitioners—not only those in the United States—on anesthesiologist support, especially when sedative medication is used. Thereby, patient safety would be enhanced and preventable deaths of patients at risk may significantly be reduced.

    PubMed data have not shown an increase of fatalities where sedation, as such, was involved when publications from the era before internet data availability were compared with those from the internet age beginning around 1995. Furthermore, when comparing the internet data after the beginning of 1995 (ie, after 1994) with PubMed data before 1995, no differences can be found regarding sedation-associated fatality rates in relation to fatality rates not associated with sedation. However, a much higher proportion of fatalities in the anesthesia, medication, or sedation category can be extracted from the internet reports. This category would have been underestimated if the internet reports had not been included in this study.

    In 2001, a recommendation from the Department of Health in the United Kingdom was published and restricted general anesthesia for dental treatment to the hospital setting [56].

    Limitations and Weaknesses of the Applied Method

    First, a standardized evaluation is difficult since some of the online reports were written by laypersons without scientific backgrounds. The authors may have reported incorrect medical data or may have used incorrect terminology, possibly resulting in the assignment of a death to an inappropriate category. Second, the assignment of the cases from the internet and PubMed publications to the cause of death categories was difficult and was based on the authors’ impressions. Some fatalities could have been allocated to more than one category. Third, terms that referred to deaths in dental offices were used, but there might be other terms that could be related to dental deaths that were not searched for when browsing the internet. Despite a precise search using Google, there might be cases that may not have been taken into account. Fourth, care was taken to exclude possible duplicate cases. By comparing fatalities before 1995 and after 1994, we have tried to fully separate the populations examined. Nevertheless, duplicates cannot be ruled out completely. Fifth, the search was restricted to six countries, which might limit the generalizability. Further research might be needed to identify differences or overlaps in dental deaths in other countries.

    The Internet as a Data Source Evaluating Casualties in Dental Facilities

    “Death in the dental office” may be a phrase that comes into the view of a regular online visitor, for example, on a news page. However, it is not a term of interest for the general public. The number of internet searchers was so low that Google Trends database analysis has not created statistics since 2004. However, dental clinicians or researchers may benefit to a large extent from the data obtained from such searches.

    The implication of scientific publications indexed by PubMed may be significantly enhanced by adding data obtained from Google database searches, such as the topic in this paper.

    Conclusions

    In this study, deaths having occurred in dental offices published on the internet and in PubMed were examined. It is advisable to be aware of the risks, no matter how low; the risk factors; and the diseases associated with dental offices in order to prevent possibly life-threatening situations in relation to dental treatment. The additional searches on the internet revealed relevant data regarding fatalities, which would have remained hidden if only extracting data from PubMed. Fatalities associated with general anesthesia or sedation would have been underrepresented, as well as the number of minors having died related to dental treatments, without the analysis of internet-based reports.

    Regarding anesthesia, especially when used with children and even with local anesthetics, the risk of overdose should not be underestimated. The type and dose of medication should be of major concern. The definitions and understanding of deep sedation and general anesthesia should be a focus in the education of dentists willing to perform adjunctive sedation during treatment, in order to be aware of associated life-threatening problems. By avoiding potentially hazardous procedures, such as sedation-aided treatments performed exclusively by the dentist without the assistance of an experienced physician or anesthesiologist, the risk of treatment-induced life-threatening emergencies may be reduced.

    Conflicts of Interest

    None declared.

    ‎
    Multimedia Appendix 1

    Searches for the words "death" and "dental" in the United States using Google Trends.

    PNG File , 220 KB
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    Multimedia Appendix 2

    Number of deaths due to anesthesia, medication, or sedation by age group using data from online publications in Germany and Austria.

    PNG File , 41 KB
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    Multimedia Appendix 3

    Number of deaths due to anesthesia, medication, or sedation in each age group using data from online publications in the United Kingdom.

    PNG File , 53 KB
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    Multimedia Appendix 4

    Number of deaths due to anesthesia, medication, or sedation in each age group using data from online publications in the United States.

    PNG File , 81 KB
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    Multimedia Appendix 5

    Number of deaths in the anesthesia, medication, or sedation category due to general anesthesia, sedation, or local anesthesia in each age group from the PubMed literature.

    PNG File , 60 KB
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    Multimedia Appendix 6

    Percentage of casualties in dental facilities for each patient age group, based on data from online publications and PubMed. Possible duplicates were not excluded.

    PNG File , 96 KB
    ‎
    Multimedia Appendix 7

    Percentage of anesthesia types used in cases of casualties in dental facilities, based on data from online publications and PubMed.

    PNG File , 68 KB
    1. Atherton GJ, McCaul JA, Williams SA. Medical emergencies in general dental practice in Great Britain. Part 1: Their prevalence over a 10-year period. Br Dent J 1999 Jan 23;186(2):72-79 [FREE Full text] [CrossRef] [Medline]
    2. Helm M, de Buhr K, Lampl L, Schramm A. Notfallmedizinische ausbildungskonzepte für studierende der zahnmedizin. Notfall Rettungsmed 2010 Oct 30;14(5):389-395. [CrossRef]
    3. Müller MP, Hänsel M, Stehr SN, Weber S, Koch T. A state-wide survey of medical emergency management in dental practices: Incidence of emergencies and training experience. Emerg Med J 2008 May;25(5):296-300. [CrossRef] [Medline]
    4. Reuter NG, Westgate PM, Ingram M, Miller CS. Death related to dental treatment: A systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Feb;123(2):194-204.e10. [CrossRef] [Medline]
    5. McLennan S, Strech D, Reimann S. Developments in the frequency of ratings and evaluation tendencies: A review of German physician rating websites. J Med Internet Res 2017 Aug 25;19(8):e299 [FREE Full text] [CrossRef] [Medline]
    6. D'eramo EM, Bookless SJ, Howard JB. Adverse events with outpatient anesthesia in Massachusetts. J Oral Maxillofac Surg 2003 Jul;61(7):793-800; discussion 800. [CrossRef] [Medline]
    7. D'Eramo EM. Morbidity and mortality with outpatient anesthesia: The Massachusetts experience. J Oral Maxillofac Surg 1992 Jul;50(7):700-704. [CrossRef] [Medline]
    8. D'Eramo EM, Bontempi WJ, Howard JB. Anesthesia morbidity and mortality experience among Massachusetts oral and maxillofacial surgeons. J Oral Maxillofac Surg 2008 Dec;66(12):2421-2433. [CrossRef] [Medline]
    9. Davies JM, Campbell LA. Fatal air embolism during dental implant surgery: A report of three cases. Can J Anaesth 1990 Jan;37(1):112-121. [CrossRef] [Medline]
    10. Forrest A, Milne N, Soon A. Hereditary angioedema: Death after a dental extraction. Aust Dent J 2017 Mar;62(1):107-110 [FREE Full text] [CrossRef] [Medline]
    11. Nkansah PJ, Haas DA, Saso MA. Mortality incidence in outpatient anesthesia for dentistry in Ontario. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Jun;83(6):646-651. [CrossRef] [Medline]
    12. Sterzik V, Tatschner T, Roewer N, Barrera D, Bohnert M. Fatal visit to the dentist. Int J Legal Med 2015 Jan;129(1):219-222. [CrossRef] [Medline]
    13. Gangemi S, Spagnolo EV, Cardia G, Minciullo PL. Fatal anaphylactic shock due to a dental impression material. Int J Prosthodont 2009;22(1):33-34. [Medline]
    14. Chicka MC, Dembo JB, Mathu-Muju KR, Nash DA, Bush HM. Adverse events during pediatric dental anesthesia and sedation: A review of closed malpractice insurance claims. Pediatr Dent 2012;34(3):231-238. [Medline]
    15. Smith MM, Barbara DW, Mauermann WJ, Viozzi CF, Dearani JA, Grim KJ. Morbidity and mortality associated with dental extraction before cardiac operation. Ann Thorac Surg 2014 Mar;97(3):838-844. [CrossRef] [Medline]
    16. Flick WG, Katsnelson A, Alstrom H. Illinois dental anesthesia and sedation survey for 2006. Anesth Prog 2007;54(2):52-58 [FREE Full text] [CrossRef] [Medline]
    17. Holmes SM, Udey DK. What are the lessons we can glean from a review of recent closed malpractice cases involving oral and maxillofacial infections? Oral Maxillofac Surg Clin North Am 2011 Nov;23(4):601-607, vii. [CrossRef] [Medline]
    18. Okada Y, Suzuki H, Ishiyama I. Fatal subarachnoid haemorrhage associated with dental local anaesthesia. Aust Dent J 1989 Aug;34(4):323-325. [CrossRef] [Medline]
    19. Lytle JJ, Stamper EP. The 1988 anesthesia survey of the Southern California Society of Oral and Maxillofacial Surgeons. J Oral Maxillofac Surg 1989 Aug;47(8):834-842. [CrossRef] [Medline]
    20. Marshall DA, Berry C, Brewer A. Fatal disseminated intravascular coagulation complicating dental extraction. Br J Oral Maxillofac Surg 1993 Jun;31(3):178-179. [CrossRef] [Medline]
    21. Coplans MP, Curson I. Deaths associated with dentistry and dental disease 1980-1989. Anaesthesia 1993 May;48(5):435-438 [FREE Full text] [CrossRef] [Medline]
    22. McKechnie J. Prostatic carcinoma presenting as a haemorrhagic diathesis after dental extraction. Br Dent J 1989 Apr 22;166(8):295-296. [CrossRef] [Medline]
    23. Bork K, Barnstedt S. Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema. J Am Dent Assoc 2003 Aug;134(8):1088-1094. [CrossRef] [Medline]
    24. Ely EW, Stump TE, Hudspeth AS, Haponik EF. Thoracic complications of dental surgical procedures: Hazards of the dental drill. Am J Med 1993 Nov;95(5):456-465. [CrossRef] [Medline]
    25. Fogarty C, Regennitter F, Viozzi CF. Invasive fungal infection of the maxilla following dental extractions in a patient with chronic obstructive pulmonary disease. J Can Dent Assoc 2006 Mar;72(2):149-152 [FREE Full text] [Medline]
    26. Kim J, Fortson JK, Cook HE. A fatal outcome from rhinocerebral mucormycosis after dental extractions: A case report. J Oral Maxillofac Surg 2001 Jun;59(6):693-697. [CrossRef] [Medline]
    27. Kunkel M, Kleis W, Morbach T, Wagner W. Severe third molar complications including death-lessons from 100 cases requiring hospitalization. J Oral Maxillofac Surg 2007 Sep;65(9):1700-1706. [CrossRef] [Medline]
    28. Levine M. Understanding how a dental infection may spread to the brain: Case report. J Can Dent Assoc 2013;79:d9 [FREE Full text] [Medline]
    29. Lopez R, Flavell S, Thomas C. A not very NICE case of endocarditis. BMJ Case Rep 2013 Jan 29;2013:1-2 [FREE Full text] [CrossRef] [Medline]
    30. Moore C, Addison D, Wilson JM, Zeluff B. First case of Fusobacterium necrophorum endocarditis to have presented after the 2nd decade of life. Tex Heart Inst J 2013;40(4):449-452 [FREE Full text] [Medline]
    31. Ricci ML, Fontana S, Pinci F, Fiumana E, Pedna MF, Farolfi P, et al. Pneumonia associated with a dental unit waterline. Lancet 2012 Feb 18;379(9816):684. [CrossRef] [Medline]
    32. Schmitt M, Puri S, Dalal NR. Aortic valve endocarditis causing fatal myocardial infarction caused by ostial coronary artery obliteration. Heart 2004 Mar;90(3):303 [FREE Full text] [CrossRef] [Medline]
    33. Wochna K, Jurczyk AP, Krajewski W, Berent J. Sudden death due to malignant hyperthermia during general anesthesia. Arch Med Sadowej Kryminol 2013;63(1):11-14, 17. [Medline]
    34. Hersh EV, Helpin ML, Evans OB. Local anesthetic mortality: Report of case. ASDC J Dent Child 1991;58(6):489-491. [Medline]
    35. No authors listed. Katie Dougal. A legacy for improvement. SAAD Dig 1998 Apr;15(2):5-7. [Medline]
    36. Auroy Y, Benhamou D, Péquignot F, Jougla E, Lienhart A. Hyponatraemia-related death after paediatric surgery still exists in France. Br J Anaesth 2008 Nov;101(5):741 [FREE Full text] [CrossRef] [Medline]
    37. Kupiec TC, Kemp P, Raj V, Kemp J. A fatality due to an accidental methadone substitution in a dental cocktail. J Anal Toxicol 2011 Sep;35(7):512-515. [CrossRef] [Medline]
    38. Dhoble A, Vedre A, Abdelmoneim SS, Sudini SR, Ghose A, Abela GS, et al. Prophylaxis to prevent infective endocarditis: To use or not to use? Clin Cardiol 2009 Aug;32(8):429-433 [FREE Full text] [CrossRef] [Medline]
    39. Malamed SF. Morbidity, mortality and local anaesthesia. Prim Dent Care 1999 Jan;6(1):11-15. [Medline]
    40. Robinson EM. Death in the dental chair. J Forensic Sci 1989 Mar;34(2):377-380. [Medline]
    41. Schulman NJ, Owens B. Medical complications following successful pediatric dental treatment. J Clin Pediatr Dent 1996;20(4):273-275. [Medline]
    42. Lee H, Milgrom P, Huebner CE, Weinstein P, Burke W, Blacksher E, et al. Ethics rounds: Death after pediatric dental anesthesia: An avoidable tragedy? Pediatrics 2017 Dec;140(6):1-6 [FREE Full text] [CrossRef] [Medline]
    43. Kaeppler G, Daubländer M, Hinkelbein R, Lipp M. Quality of cardiopulmonary resuscitation by dentists in dental emergency care [Article in German]. Mund Kiefer Gesichtschir 1998 Mar;2(2):71-77. [CrossRef] [Medline]
    44. Schmelzeisen R. Zahnärztliche Mitteilungen. 2002. Zahnärztliche chirurgie bei patienten mit antikoagulantientherapie   URL: https:/​/www.​zm-online.de/​archiv/​2002/​07/​zahnmedizin/​zahnaerztliche-chirurgie-bei-patienten-mit- antikoagulantientherapie/​ [accessed 2020-02-09]
    45. Kamoh A, Swantek J. Hemostasis in oral surgery. Dent Clin North Am 2012 Jan;56(1):17-23, vii. [CrossRef] [Medline]
    46. Hoen B, Alla F, Selton-Suty C, Béguinot I, Bouvet A, Briançon S, Association pour l'Etude et la Prévention de l'Endocardite Infectieuse (AEPEI) Study Group. Changing profile of infective endocarditis: Results of a 1-year survey in France. JAMA 2002 Jul 03;288(1):75-81. [CrossRef] [Medline]
    47. Selton-Suty C, Célard M, Le Moing V, Doco-Lecompte T, Chirouze C, Iung B, AEPEI Study Group. Preeminence of Staphylococcus aureus in infective endocarditis: A 1-year population-based survey. Clin Infect Dis 2012 May;54(9):1230-1239. [CrossRef] [Medline]
    48. Duval X, Delahaye F, Alla F, Tattevin P, Obadia J, Le Moing V, AEPEI Study Group. Temporal trends in infective endocarditis in the context of prophylaxis guideline modifications: Three successive population-based surveys. J Am Coll Cardiol 2012 May 29;59(22):1968-1976 [FREE Full text] [CrossRef] [Medline]
    49. Tleyjeh IM, Steckelberg JM, Murad HS, Anavekar NS, Ghomrawi HM, Mirzoyev Z, et al. Temporal trends in infective endocarditis: A population-based study in Olmsted County, Minnesota. JAMA 2005 Jun 22;293(24):3022-3028. [CrossRef] [Medline]
    50. Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med 2001 Nov 01;345(18):1318-1330. [CrossRef] [Medline]
    51. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta J, Del Zotti F, ESC Scientific Document Group. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015 Nov 21;36(44):3075-3128. [CrossRef] [Medline]
    52. Girdler NM. Fatal sequel to dental implant surgery. J Oral Rehabil 1994 Nov;21(6):721-722. [CrossRef] [Medline]
    53. Tse K, Zuraw BL. Recognizing and managing hereditary angioedema. Cleve Clin J Med 2013 May;80(5):297-308 [FREE Full text] [CrossRef] [Medline]
    54. Cohen S, Schwartz S. Endodontic complications and the law. J Endod 1987 Apr;13(4):191-197. [CrossRef] [Medline]
    55. Boynes SG, editor. Dental Anesthesiology: A Guide to the Rules and Regulations of the United States of America. 6th edition. Pittsburgh, PA: No-No Orchard Publishing; 2018.
    56. Pike D. A conscious decision. A review of the use of general anaesthesia and conscious sedation in primary dental care. SAAD Dig 2000 Jul;17(3):13-14. [Medline]

    Edited by G Eysenbach; submitted 30.06.19; peer-reviewed by M Kurrer, A Lau; comments to author 29.09.19; revised version received 29.12.19; accepted 03.02.20; published 17.04.20

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    ©Meike Gaiser, Joachim Kirsch, Till Sebastian Mutzbauer. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 17.04.2020.

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