Exploring the Hierarchical Influence of Cognitive Functions for Alzheimer Disease: The Framingham Heart Study

Huitong Ding   ^{1, 2, 3} , BSc ;   Ning An   ^{1, 2} , PhD ;   Rhoda Au   ^{3, 4, 5, 6} , PhD ;   Sherral Devine   ^{3, 5} , PhD ;   Sanford H Auerbach   ^{5, 6} , MD ;   Joseph Massaro   ^{5, 7} , PhD ;   Prajakta Joshi   ^{3, 5} , MPH ;   Xue Liu   ^{3, 5} , MPH, MSc ;   Yulin Liu   ^{3, 5} , MSc ;   Elizabeth Mahon   ^{3, 5} , BA ;   Ting FA Ang   ^{3, 4, 5 *} , MD, MPH ;   Honghuang Lin   ^{5, 8 *} , PhD

¹ School of Computer Science and Information Engineering, Hefei University of Technology, Hefei, China

² Key Laboratory of Knowledge Engineering with Big Data of Ministry of Education, Hefei University of Technology, Hefei, China

³ Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States

⁴ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital | Harvard Medical School, Boston, MA, United States

⁵ The Framingham Heart Study, Framingham, MA, United States

⁶ Department of Neurology, Boston University School of Medicine, Boston, MA, United States

⁷ Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States

⁸ Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, United States

*these authors contributed equally